US4640778A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Fibrin gel-containing filter
Assignee: New York Blood Center
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Filing: 1982-07-06
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Granted: 1987-02-03
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Expires: 2002-07-06
Abstract
Abstract There is disclosed a filter comprising fibrin in gel form, the gel having substantially uniform pore sizes, and the filter comprising means for retaining the shape of at least one surface of the gel against deformation when contacted by a flowing medium.
Inventors
- 👤 Birger Blomback
- 👤 Masahisa Okada
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 02:02
CPC Classifications
C; C12; C12N; C12N11/00; C12N11/02; C12N11/04; B; B01; B01D; B01D39/00; B01D71/00; B01D71/06; B01D71/74; C07; C07K; C07K14/00; C07K14/435; C07K14/745; C07K14/755; C12N1/00; C12N1/02; C12N7/00; A; A61; A61K; A61K38/00; C12N2760/00; C12N2760/00011; C12N2760/18011; C12N2760/18811; C12N2760/18851; Y; Y02; Y02A; Y02A50/00; Y02A50/30; Y10; Y10S; Y10S435/00; Y10S435/811; Y10S435/82; Y10T; Y10T436/00; Y10T436/25; Y10T436/25375; Y10T436/255
Claims Analysis
Total Claims: 42
Claim 1
Independent Claim
53 words
A filter comprising fibrin in gel form, said gel having substantially uniform pore sizes, said filter comprising means for retaining the shape of at least the upper surface of said gel against deformation when contacted by a flowing medium, said means for retaining the shape comprising a foraminous sheet member or a foam.
Claim 2
Dependent Claim
53 words
A filter comprising fibrin in gel form, said gel having substantially uniform pore sizes, said filter comprising means for retaining the shape of at least the upper surface of said gel against deformation when contacted by a flowing medium, said means for retaining the shape comprising a foraminous sheet member or a foam.
Claim 3
Dependent Claim
15 words
A filter according to claim 1 wherein said shape-retaining means comprises a foraminous sheet member.
Claim 4
Dependent Claim
17 words
A filter according to claim 2 wherein said foraminous sheet member is in contact with said gel.
Claim 5
Dependent Claim
15 words
A filter according to claim 3 wherein said foraminous sheet member comprises a fibrous network.
Claim 6
Dependent Claim
13 words
A filter according to claim 4 wherein said network comprises a woven fabric.
Claim 7
Dependent Claim
13 words
A filter according to claim 4 wherein said network comprises a knitted fabric.
Claim 8
Dependent Claim
13 words
A filter according to claim 4 wherein said network comprises a non-woven fabric.
Claim 9
Dependent Claim
15 words
A filter according to claim 4 wherein said fibrous network comprises a sheet containing silk.
Claim 10
Dependent Claim
15 words
A filter according to claim 4 wherein said fibrous network comprises a sheet containing nylon.
Claim 11
Dependent Claim
15 words
A filter according to claim 4 wherein said fibrous network comprises a sheet containing cellulose.
Claim 12
Dependent Claim
15 words
A filter according to claim 4 wherein said fibrous network comprises a sheet containing cotton.
Claim 13
Dependent Claim
17 words
A filter according to claim 4 wherein said fibrous network comprises a sheet containing a natural fiber.
Claim 14
Dependent Claim
17 words
A filter according to claim 4 wherein said fibrous network comprises a sheet containing a synthetic fiber.
Claim 15
Dependent Claim
19 words
A filter according to claim 2 wherein said shape-retaining means comprises a plurality of wires which intersect one another.
Claim 16
Dependent Claim
15 words
A filter according to claim 14 wherein said wires are in contact with said gel.
Claim 17
Dependent Claim
17 words
A filter according to claim 15 wherein said wires are in the form of a wire screen.
Claim 18
Dependent Claim
17 words
A filter according to claim 15 wherein said wires are in the form of a wire mesh.
Claim 19
Dependent Claim
18 words
A filter according to claim 15 wherein said wires are in the form of an expanded wire sheet.
Claim 20
Dependent Claim
12 words
A filter according to claim 15 wherein said wires are metal wires.
Claim 21
Dependent Claim
20 words
A filter according to claim 1 wherein the average effective size of said fibrin gel is 0.003 to 1.0 μm.
Claim 22
Dependent Claim
20 words
A filter according to claim 1 wherein the average effective size of said firbin gel is 0.009 to 0.3 μm.
Claim 23
Dependent Claim
18 words
A filter according to claim 1 wherein said fibrin gel is formed by contacting fibrinogen with an enzyme.
Claim 24
Dependent Claim
13 words
A filter according to claim 22 wherein said enzyme is a coagulation enzyme.
Claim 25
Dependent Claim
27 words
A filter according to claim 23 wherein said coagulation enzyme is selected from the group consisting of thrombin, Batroxobin, Arvin, Eccarin, Papain, Staphylocoagulase, Trypsin, caterpillar venom enzyme.
Claim 26
Dependent Claim
25 words
A filter according to claim 23 wherein said fibrinogen is brought in contact with said enzyme in the presence of at least one calcium ion.
Claim 27
Dependent Claim
21 words
A filter according to claim 25 wherein the calcium ion concentration in the gel formation mixture is up to 20 mM.
Claim 28
Dependent Claim
23 words
A filter according to claim 23 wherein the enzyme is thrombin and the gel is prepared in the absence of a calcium ion.
Claim 29
Dependent Claim
11 words
A filter according to claim 25 wherein said enzyme is Batroxobin.
Claim 30
Dependent Claim
23 words
A filter according to claim 1 wherein said fibrin gel is a crosslinked fibrin gel and said shape-retaining means is a crosslinking agent.
Claim 31
Dependent Claim
22 words
A filter according to claim 29 wherein said crosslinking agent is selected from the group consisting of dialdehydes, azides, aromaticdihalides, and bis-imidates.
Claim 32
Dependent Claim
12 words
A filter according to claim 29 wherein said crosslinking agent is glutardialdehyde.
Claim 33
Dependent Claim
20 words
A filter according to claim 1 wherein said gel is crosslinked and said shape-retaining means comprises a foraminous sheet member.
Claim 34
Dependent Claim
15 words
A filter according to claim 32 wherein said foraminous sheet member comprises a fibrous network.
Claim 35
Dependent Claim
19 words
A filter according to claim 1 wherein said gel has disposed on its lower surface a second shape-retaining means.
Claim 36
Dependent Claim
15 words
A filter according to claim 34 wherein said second shape-retaining means comprises a forminous sheet.
Claim 37
Dependent Claim
16 words
A filter according to claim 1 wherein said gel is adhesively secured to said shape-retaining means.
Claim 38
Dependent Claim
15 words
A filter according to claim 1 wherein said gel is grafted to said shape-retaining means.
Claim 39
Dependent Claim
26 words
A filter according to claim 1 wherein said shape-retaining means is a foraminous member having pores or openings of a size of 0.01 to 5 mm.
Claim 40
Dependent Claim
13 words
A filter according to claim 1, wherein said shape-retaining means comprises a foam.
Claim 41
Dependent Claim
13 words
A filter according to claim 39, wherein said foam is a plastic foam.
Claim 42
Dependent Claim
11 words
A filter according to claim 40, wherein said plastic is polyurethane.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1990-02-02 | 1990-08-04 | 1991-02-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-02-02 | 1994-08-04 | 1995-02-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-02-02 | 1998-08-04 | 1999-02-03 | $7700.00 | Window Closed / Lapsed |