US5225520A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Absorbable composition
Assignee: United States Surgical Corp
•
Filing: 1991-04-17
•
Granted: 1993-07-06
•
Expires: 2011-04-17
Abstract
Abstract A block copolymer for use in the fabrication of bioabsorbable articles such as monofilament surgical sutures is prepared by copolymerizing lactide and 1,4-dioxanone, and then polymerizing glycolide with the lactide/1,4-dioxanone copolymer.
Inventors
- 👤 John Kennedy
- 👤 Donald S. Kaplan
- 👤 Ross R. Muth
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:21
CPC Classifications
C; C08; C08G; C08G63/00; C08G63/66; C08G63/664; A; A61; A61L; A61L17/00; A61L17/06; A61L17/10; A61L17/12; C08G63/02; C08G63/06; C08G63/08
Claims Analysis
Total Claims: 34
Claim 1
Independent Claim
52 words
A block copolymer which comprises a proportion of units having the formula: ##STR4## as one of said blocks, and another of said blocks comprising a proportion of units having the formula: ##STR5## and a proportion of units having the formula: ##STR6## said units of formula (II) and formula (III) being randomly combined.
Claim 2
Dependent Claim
52 words
A block copolymer which comprises a proportion of units having the formula: ##STR4## as one of said blocks, and another of said blocks comprising a proportion of units having the formula: ##STR5## and a proportion of units having the formula: ##STR6## said units of formula (II) and formula (III) being randomly combined.
Claim 3
Dependent Claim
14 words
The block copolymer of claim 1 wherein said block copolymer is a diblock copolymer.
Claim 4
Dependent Claim
26 words
The block copolymer of claim 1 wherein from about 55 weight % to about 85 weight % of the block copolymer comprises units of formula (I).
Claim 5
Dependent Claim
26 words
The block copolymer of claim 1 wherein from about 1 weight % to about 20 weight % of the block copolymer comprises units of formula (II).
Claim 6
Dependent Claim
26 words
The block copolymer of claim 1 wherein from about 10 weight % to about 40 weight % of the block copolymer comprises units of formula (III).
Claim 7
Dependent Claim
57 words
A surgical article manufactured from a block copolymer which comprises a proportion of units having the formula: ##STR7## as one of said blocks, and another of said blocks comprising a proportion of units having the formula: ##STR8## and a proportion of units having the formula: ##STR9## said units of formula (II) and formula (III) being randomly combined.
Claim 8
Dependent Claim
57 words
A surgical article manufactured from a block copolymer which comprises a proportion of units having the formula: ##STR7## as one of said blocks, and another of said blocks comprising a proportion of units having the formula: ##STR8## and a proportion of units having the formula: ##STR9## said units of formula (II) and formula (III) being randomly combined.
Claim 9
Dependent Claim
14 words
The surgical article of claim 6 wherein said block copolymer is a diblock copolymer.
Claim 10
Dependent Claim
13 words
The surgical article of claim 6 wherein said surgical article is a suture.
Claim 11
Dependent Claim
13 words
The surgical article of claim 8 wherein said suture is a monofilament suture.
Claim 12
Dependent Claim
66 words
The surgical article of claim 6 wherein from about 55 weight % to about 85 weight % of the block copolymer comprises units of formula (I), and from about 1 weight % to about 20 weight % of the block copolymer comprises units of formula (II), and from about 10 weight % to about 40 weight % of the block copolymer comprises units of formula (III).
Claim 13
Independent Claim
48 words
A method for preparing a bioabsorbable block copolymer, comprising: a) polymerizing a mixture of lactide and 1,4-dioxanone at a first reaction temperature to create a copolymer thereof; b) polymerizing glycolide with the lactide/1,4-dioxanone copolymer of step (a) at a second reaction temperature to create the bioabsorbable block copolymer.
Claim 14
Independent Claim
48 words
A method for preparing a bioabsorbable block copolymer, comprising: a) polymerizing a mixture of lactide and 1,4-dioxanone at a first reaction temperature to create a copolymer thereof; b) polymerizing glycolide with the lactide/1,4-dioxanone copolymer of step (a) at a second reaction temperature to create the bioabsorbable block copolymer.
Claim 15
Dependent Claim
13 words
The method of claim 11 wherein said block copolymer is a diblock copolymer.
Claim 16
Dependent Claim
22 words
The method of claim 11 wherein said first reaction temperature comprises a temperature of from about 100° C. to about 150° C.
Claim 17
Dependent Claim
22 words
The method of claim 11 wherein said second reaction temperature comprises a temperature of from about 200° C. to about 250° C.
Claim 18
Dependent Claim
18 words
The method of claim 11 wherein step (a) is carried out in the presence of a polymerization catalyst.
Claim 19
Dependent Claim
11 words
The method of claim 15 wherein said catalyst is stannous octoate.
Claim 20
Dependent Claim
59 words
The method of claim 15 wherein said catalyst is selected from the group consisting of stannous chloride, dibutyl tin dilaurate, dibutyl tin diacetate, dibutyl tin dichloride, stannic chloride pentahydrate, aluminum isopropoxide, antimony trioxide, stannic fluoride, stannous citrate, stannous acetate, antimony trifluoride, tin tetraisopropoxide, lead oxide, tetraisopropyl titanate, titanium acetyl acetonate, tetraoctylene glycol titanate, boron trifluoride etherate, and aluminum trichloride.
Claim 21
Independent Claim
53 words
A method for making a bioabsorbable surgical article, comprising: a) polymerizing a mixture of lactide and 1,4-dioxanone at a first reaction temperature to create a copolymer thereof; b) polymerizing glycolide with the lactide/1,4-dioxanone copolymer of step (a) at a second reaction temperature to create a bioabsorbable block copolymer; c) forming said block copolymer.
Claim 22
Independent Claim
53 words
A method for making a bioabsorbable surgical article, comprising: a) polymerizing a mixture of lactide and 1,4-dioxanone at a first reaction temperature to create a copolymer thereof; b) polymerizing glycolide with the lactide/1,4-dioxanone copolymer of step (a) at a second reaction temperature to create a bioabsorbable block copolymer; c) forming said block copolymer.
Claim 23
Dependent Claim
19 words
The method of claim 18 wherein said forming includes the step of extruding the block copolymer into a filament.
Claim 24
Dependent Claim
13 words
The method of claim 19 wherein the bioabsorbable surgical article comprises a suture.
Claim 25
Dependent Claim
14 words
The method of claim 20 additionally comprising drawing the suture and relaxing the suture.
Claim 26
Dependent Claim
13 words
The method of claim 18 wherein said block copolymer is a diblock copolymer.
Claim 27
Dependent Claim
22 words
The method of claim 18 wherein said first reaction temperature comprises a temperature of from about 100° C. to about 150° C.
Claim 28
Dependent Claim
22 words
The method of claim 18 wherein said second reaction temperature comprises a temperature of from about 200° C. to about 250° C.
Claim 29
Dependent Claim
18 words
The method of claim 18 wherein step (a) is carried out in the presence of a polymerization catalyst.
Claim 30
Dependent Claim
11 words
The method of claim 25 wherein said catalyst is stannous octoate.
Claim 31
Dependent Claim
59 words
The method of claim 25 wherein said catalyst is selected from the group consisting of stannous chloride, dibutyl tin dilaurate, dibutyl tin diacetate, dibutyl tin dichloride, stannic chloride pentahydrate, aluminum isopropoxide, antimony trioxide, stannic fluoride, stannous citrate, stannous acetate, antimony trifluoride, tin tetraisopropoxide, lead oxide, tetraisopropyl titanate, titanium acetyl acetonate, tetraoctylene glycol titanate, boron trifluoride etherate, and aluminum trichloride.
Claim 32
Dependent Claim
25 words
The method of claim 18 wherein from about 55 weight % to about 85 weight % of the block copolymer comprises units derived from glycolide.
Claim 33
Dependent Claim
25 words
The method of claim 18 wherein from about 1 weight % to about 20 weight % of the block copolymer comprises units derived from lactide.
Claim 34
Dependent Claim
25 words
The method of claim 18 wherein from about 10 weight % to about 40 weight % of the block copolymer comprises units derived from 1,4-dioxanone.
References Cited (Backward Citations)
US3839297A
Cited
US4429080A
Cited
US4438253A
Cited
US4452973A
Cited
US4440789A
Cited
US4646741A
Cited
US4595713A
Cited
US4643191A
Cited
US4653497A
Cited
US4744365A
Cited
US4716203A
Cited
US4857602A
Cited
US4788979A
Cited
US5123912A
Cited
US4838267A
Cited
EP0411545A1
Cited
US5047048A
Cited
EP0440448A1
Cited
US5019094A
Cited
US5080665A
Cited
EP0509508A2
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-07-05 | 1997-01-04 | 1997-07-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-07-05 | 2001-01-04 | 2001-07-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-07-05 | 2005-01-04 | 2005-07-06 | $7700.00 | Window Closed / Lapsed |