Patent US2143141A successfully refreshed from Google Patents.
EP0509508A2
Expired / Lapsed
EP
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Block copolymer, method for preparing it and use thereof, surgical article and method for preparing it
Assignee: United States Surgical Corp
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Filing: 1992-04-16
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Granted: —
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Expires: 2012-04-16
Abstract
Abstract This invention relates to a block copolymer which comprises a proportion of units having the formula: as one of said blocks, and another of said blocks comprising a proportion of units having the formula: and a proportion of units having the formula: said units of formula (II) and formula (III) being randomly combined. This invention relates further to a surgical article manufactured from this block copolymer. A method for preparing the bioabsorbable block copolymer as well as for preparing a bioabsorbable surgical article are also disclosed.
Inventors
- 👤 John Kennedy
- 👤 Donald S. Kaplan
- 👤 Ross R. Muth
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-24 09:19
CPC Classifications
C; C08; C08G; C08G63/00; C08G63/66; C08G63/664; A; A61; A61L; A61L17/00; A61L17/06; A61L17/10; A61L17/12; C08G63/02; C08G63/06; C08G63/08
Claims Analysis
Total Claims: 46
Claim 1
Independent Claim
49 words
A block copolymer which comprises a proportion of units having the formula: as one of said blocks, and another of said blocks comprising a proportion of units having the formula: and a proportion of units having the formula: said units of formula (II) and formula (III) being randomly combined.
Claim 2
Dependent Claim
49 words
A block copolymer which comprises a proportion of units having the formula: as one of said blocks, and another of said blocks comprising a proportion of units having the formula: and a proportion of units having the formula: said units of formula (II) and formula (III) being randomly combined.
Claim 3
Dependent Claim
14 words
The block copolymer of claim 1, wherein said block copolymer is a diblock copolymer.
Claim 4
Dependent Claim
67 words
The block copolymer of claim 1 or 2, wherein from about 55 weight % to about 85 weight % of the block copolymer comprises units of formula (I), from about 1 weight % to about 20 weight % of the block copolymer comprises units of formula (II), and from about 10 weight % to about 40 weight % of the block copolymer comprises units of formula (III).
Claim 5
Dependent Claim
54 words
A surgical article manufactured from a block copolymer which comprises a proportion of units having the formula: as one of said blocks, and another of said blocks comprising a proportion of units having the formula: and a proportion of units having the formula: said units of formula (II) and formula (III) being randomly combined.
Claim 6
Dependent Claim
54 words
A surgical article manufactured from a block copolymer which comprises a proportion of units having the formula: as one of said blocks, and another of said blocks comprising a proportion of units having the formula: and a proportion of units having the formula: said units of formula (II) and formula (III) being randomly combined.
Claim 7
Dependent Claim
14 words
The surgical article of claim 4, wherein said block copolymer is a diblock copolymer.
Claim 8
Dependent Claim
15 words
The surgical article of claim 4 or 5, wherein said surgical article is a suture.
Claim 9
Dependent Claim
13 words
The surgical article of claim 6, wherein said suture is a monofilament suture.
Claim 10
Dependent Claim
73 words
The surgical article according to any one of the claims 4 to 7, wherein from about 55 weight % to about 85 weight % of the block copolymer comprises units of formula (I), and from about 1 weight % to about 20 weight % of the block copolymer comprises units of formula (II), and from about 10 weight % to about 40 weight % of the block copolymer comprises units of formula (III).
Claim 11
Independent Claim
48 words
A method for preparing a bioabsorbable block copolymer, comprising: (a) polymerizing a mixture of lactide and 1,4-dioxanone at a first reaction temperature to create a copolymer thereof; (b) polymerizing glycolide with the lactide/1,4-dioxanone copolymer of step (a) at a second reaction temperature to create the bioabsorbable block copolymer.
Claim 12
Independent Claim
48 words
A method for preparing a bioabsorbable block copolymer, comprising: (a) polymerizing a mixture of lactide and 1,4-dioxanone at a first reaction temperature to create a copolymer thereof; (b) polymerizing glycolide with the lactide/1,4-dioxanone copolymer of step (a) at a second reaction temperature to create the bioabsorbable block copolymer.
Claim 13
Dependent Claim
19 words
The method of claim 9, wherein said first reaction temperature comprises a temperature of from about 100°Cto about 150°C.
Claim 14
Dependent Claim
26 words
The method of claim 9 or 10, wherein said second reaction temperature comprises a temperature of from about 200 ° C to about 250 ° C.
Claim 15
Independent Claim
25 words
The method according to any one of the claims 9 to 11, wherein step (a) is carried out in the presence of a polymerization catalyst.
Claim 16
Dependent Claim
59 words
The method of claim 12, wherein said catalyst is selected from the group consisting of stannous chloride, dibutyl tin dilaurate, dibutyl tin diacetate, dibutyl tin dichloride, stannic chloride pentahydrate, aluminum isopropoxide, antimony trioxide, stannic fluoride, stannous citrate, stannous acetate, antimony trifluoride, tin tetraisopropoxide, lead oxide, tetraisopropyl titanate, titanium acetyl acetonate, tetraoctylene glycol titanate, boron trifluoride etherate, and aluminum trichloride.
Claim 17
Independent Claim
53 words
A method for making a bioabsorbable surgical article comprising: (a) polymerising a mixture of lactide and 1,4-dioxanone at a first reaction temperature to create a copolymer thereof; (b) polymerizing glycolide with the lactide/1,4-dioxanone copolymer of step (a) at a second reaction temperature to create a bioabsorbable block copolymer; (c) forming said block copolymer.
Claim 18
Independent Claim
53 words
A method for making a bioabsorbable surgical article comprising: (a) polymerising a mixture of lactide and 1,4-dioxanone at a first reaction temperature to create a copolymer thereof; (b) polymerizing glycolide with the lactide/1,4-dioxanone copolymer of step (a) at a second reaction temperature to create a bioabsorbable block copolymer; (c) forming said block copolymer.
Claim 19
Dependent Claim
19 words
The method of claim 14, wherein said forming includes the step of extruding the block copolymer into a filament.
Claim 20
Dependent Claim
15 words
The method of claim 14 or 15, wherein the bioabsorbable surgical article comprises a suture.
Claim 21
Independent Claim
29 words
The method according to any one of the claims 14 to 16, wherein said first reaction temperature comprises a temperature of from about 100 °C to about 150 C.
Claim 22
Independent Claim
30 words
The method according to any one of the claims 14 to 17, wherein said second reaction temperature comprises a temperature of from about 200 ° C to 250 ° C.
Claim 23
Independent Claim
25 words
The method according to any one of the claims 14 to 18, wherein step (a) is carried out in the presence of a polymerization catalyst.
Claim 24
Independent Claim
71 words
The method according to any one of the claims 14 to 19, wherein from about 55 weight % to about 85 weight % of the block copolymer comprises units derived from glycolide, from about 1 weight % to about 20 weight % of the block copolymer comprises units derived from lactide and from about 10 weight % to about 40 weight % of the block copolymer comprises units derived from 1,4-dioxanone.
Claim 25
Dependent Claim
19 words
Use of a block copolymer according to any one of the claims 1 to 3 for preparing bioabsorbable articles.
Claim 26
Dependent Claim
8 words
Claims for the following Contracting State : ES
Claim 27
Independent Claim
95 words
A method for preparing a bioabsorbable block copolymer, which comprises a proportion of units having the formula: as one of said blocks, and another of said blocks comprising a proportion of units having the formula: and a proportion of units having the formula: said units of formula (II) and formula (III) being randomly combined characterized by: (a) polymerizing a mixture of lactide and 1,4-dioxanone at a first reaction temperature to create a copolymer thereof; (b) polymerizing glycolide with the lactide/1,4-dioxanone copolymer of step (a) at a second reaction temperature to create the bioabsorbable block copolymer.
Claim 28
Independent Claim
95 words
A method for preparing a bioabsorbable block copolymer, which comprises a proportion of units having the formula: as one of said blocks, and another of said blocks comprising a proportion of units having the formula: and a proportion of units having the formula: said units of formula (II) and formula (III) being randomly combined characterized by: (a) polymerizing a mixture of lactide and 1,4-dioxanone at a first reaction temperature to create a copolymer thereof; (b) polymerizing glycolide with the lactide/1,4-dioxanone copolymer of step (a) at a second reaction temperature to create the bioabsorbable block copolymer.
Claim 29
Dependent Claim
18 words
Method of Claim 1, wherein said first reaction temperature comprises a temperature of from about 100°Cto about 150°C.
Claim 30
Dependent Claim
25 words
Method of claim 1 or 2, wherein said second reaction temperature comprises a temperature of from about 200 ° C to about 250 ° C.
Claim 31
Dependent Claim
24 words
Method according to any one of the claims 1 to 3, wherein step (a) is carried out in the presence of a polymerization catalyst.
Claim 32
Dependent Claim
58 words
Method of claim 4, wherein said catalyst is selected from the group consisting of stannous chloride, dibutyl tin dilaurate, dibutyl tin diacetate, dibutyl tin dichloride, stannic chloride pentahydrate, aluminum isopropoxide, antimony trioxide stannic fluoride, stannous citrate, stannous acetate, antimony trifluoride, tin tetraisopropoxide, lead oxide, tetraisopropyl titanate, titanium acetyl acetonate, tetraoctylene glycol titanate, boron trifluoride etherate, and aluminum trichloride.
Claim 33
Dependent Claim
19 words
Method according to any one of the claims 1 to 5, wherein said block copolymer is a diblock copolymer.
Claim 34
Dependent Claim
70 words
Method according to any one of the claims 1 to 6, wherein from about 55 weight % to about 85 weight % of the block copolymer comprises units of formula (I), from about 1 weight % to about 20 weight % of the block copolymer comprises units of formula (II), and from about 10 weight % to about 40 weight % of the block copolymer comprises units of formula (III).
Claim 35
Independent Claim
100 words
A method for making a bioabsorbable surgical article, which comprises a proportion of units having the formula: as one of said blocks, and another of said blocks comprising a proportion of units having the formula: and a proportion of units having the formula: said units of formula (II) and formula (III) being randomly combined characterized by: (a) polymerizing a mixture of lactide and 1,4-dioxanone at a first reaction temperature to create a copolymer thereof; (b) polymerizing glycolide with the lactide/1,4-dioxanone copolymer of step (a) at a second reaction temperature to create a bioabsorbable block copolymer; (c) forming said block copolymer.
Claim 36
Independent Claim
100 words
A method for making a bioabsorbable surgical article, which comprises a proportion of units having the formula: as one of said blocks, and another of said blocks comprising a proportion of units having the formula: and a proportion of units having the formula: said units of formula (II) and formula (III) being randomly combined characterized by: (a) polymerizing a mixture of lactide and 1,4-dioxanone at a first reaction temperature to create a copolymer thereof; (b) polymerizing glycolide with the lactide/1,4-dioxanone copolymer of step (a) at a second reaction temperature to create a bioabsorbable block copolymer; (c) forming said block copolymer.
Claim 37
Dependent Claim
18 words
Method of claim 8, wherein said forming includes the step of extruding the block copolymer into a filament.
Claim 38
Dependent Claim
14 words
Method of claim 8 or 9, wherein the bioabsorbable surgical article comprises a suture.
Claim 39
Dependent Claim
28 words
Method according to any one of the claims 8 to 10, wherein said first reaction temperature comprises a temperature of from about 100 °C to about 150 C.
Claim 40
Dependent Claim
29 words
Method according to any one of the claims 8 to 11, wherein said second reaction temperature comprises a temperature of from about 200 ° C to 250 ° C.
Claim 41
Dependent Claim
24 words
Method according to any one of the claims 8 to 12, wherein step (a) is carried out in the presence of a polymerization catalyst.
Claim 42
Dependent Claim
69 words
Method according to any one of the claims 8 to 13, wherein from about 55 weight % to about 85 weight % of the block copolymer comprises units derived from glycolide, from about 1 weight % to about 20 weight % of the block copolymer comprises units derived from lactide and from about 10 weight to about 40 weight % of the block copolymer comprises units derived from 1,4-dioxanone.
Claim 43
Dependent Claim
19 words
Method according to any one of the claims 8 to 14, wherein said block copolymer is a diblock copolymer.
Claim 44
Dependent Claim
18 words
Method according to any one of the claims 8 to 15, wherein said surgical article is a suture.
Claim 45
Dependent Claim
12 words
Method according to claim 16, wherein said suture is a monofilament suture.
Claim 46
Dependent Claim
71 words
Method according to any one of the claims 8 to 17, wherein from about 55 weight % to about 85 weight % of the block copolymer comprises units of formula (I), and from about 1 weight % to about 20 weight % of the block copolymer comprises units of formula (II), and from about 10 weight % to about 40 weight % of the block copolymer comprises units of formula (III).
References Cited (Backward Citations)
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