Patent US5165938A successfully refreshed from Google Patents.
US5165938A
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US
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Wound healing agents derived from platelets
Assignee: Cytomedix Inc
•
Filing: 1990-05-18
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Granted: 1992-11-24
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Expires: 2010-05-18
Abstract
Abstract Platelet enriched plasma is produced from blood. The platelets are activated by thrombin which causes the release of platelet derived growth and angiogenesis factors. A carrier such as a microcrystalline collagen is added to produce a wound treating salve. The compound is applied directly to wounds and initiates healing in non-healing wounds as well as accelerating normal wound healing by increasing vascularization, stimulating fibroblast mitosis and migration and increasing collagen synthesis by fibroblasts. The process of treatment involves the use of a composition containing the materials released by platelets during the platelet release reaction.
Inventors
- 👤 David R. Knighton
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 17:19
CPC Classifications
A; A61; A61L; A61L26/00; A61L26/0061; A61L26/0066; A61K; A61K35/00; A61K35/12; A61K35/14; A61K35/16; A61K47/00; A61K47/30; A61K47/42; A61L26/0009; A61L26/0028; A61L26/0033; A61L2300/00; A61L2300/40; A61L2300/412; A61L2300/60; A61L2300/64
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
40 words
A process for treating damaged, live, animal tissue which comprises applying over the damaged tissue an effective amount of a treating composition containing the materials released by platelets during the platelet release reaction and facilitating healing of the damaged tissue.
Claim 2
Dependent Claim
40 words
A process for treating damaged, live, animal tissue which comprises applying over the damaged tissue an effective amount of a treating composition containing the materials released by platelets during the platelet release reaction and facilitating healing of the damaged tissue.
Claim 3
Dependent Claim
29 words
The method of claim 1 wherein the materials are applied topically in an amount sufficient to cause migration and/or division of fibroblast cells, capillary endothelial cells and/or epithelial cells.
Claim 4
Dependent Claim
18 words
The method of claim 1 wherein said platelets are isolated from blood prior to release of the materials.
Claim 5
Dependent Claim
11 words
The method of claim 1 wherein said tissue is mammalian tissue.
Claim 6
Dependent Claim
11 words
The method of claim 4 wherein said tissue is human tissue.
Claim 7
Dependent Claim
11 words
The method of claim 1 wherein said platelets are mammalian platelets.
Claim 8
Dependent Claim
11 words
The method of claim 6 wherein said platelets are human platelets.
Claim 9
Dependent Claim
24 words
The method of claim 7 wherein prior to release of the materials said platelets were removed from the person whose tissue is being treated.
Claim 10
Dependent Claim
30 words
The method of claim 7 wherein prior to release of the materials said platelets were removed from a person or persons other than the person whose tissue is being treated.
Claim 11
Dependent Claim
29 words
The method of claim 1 wherein the materials are released from said platelets by use of an activator selected from the group consisting of thrombin, adenosine diphosphate and collagen.
Claim 12
Dependent Claim
10 words
The method of claim 10 wherein said activator is thrombin.
Claim 13
Dependent Claim
40 words
A process for treating a wound of a live animal which comprises applying over the wound an effective amount of a treating composition containing the materials released by platelets during the platelet release reaction and facilitating healing of the wound.
Claim 14
Dependent Claim
40 words
A process for treating a wound of a live animal which comprises applying over the wound an effective amount of a treating composition containing the materials released by platelets during the platelet release reaction and facilitating healing of the wound.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-11-24 | 1996-05-25 | 1996-11-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-11-24 | 2000-05-25 | 2000-11-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-11-24 | 2004-05-25 | 2004-11-24 | $7700.00 | Window Closed / Lapsed |