US3883574A
Expired / Lapsed
US
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Prostaglandin A{HD 3 {B analogs
Assignee: Pharmacia and Upjohn Co
•
Filing: 1973-11-05
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Granted: 1975-05-13
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Expires: 1993-11-05
Abstract
Abstract This disclosure relates to prostaglandins of the PG3 series including PGE3, PGF3 , PGF3 , PGA3, and PGB3, to various analogs of those in racemic form, and to novel processes for making those. This disclosure also relates to certain fluorine and alkyl substituted analogs and certain acetylenic analogs of PGE3, PGF3 , PGF3 , PGA3, and PGB3 in both racemic and optically active form, and to processes for making those. These various analogs are useful for the same pharmacological purposes as the known optically active forms of PGE3, PGF3 , PGF3 , PGA3, and PGB3, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement, fertility control, and wound healing.
Inventors
- 👤 Udo F Axen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 23:55
CPC Classifications
C; C07; C07C; C07C405/00; C07C35/00; C07C35/22; C07C35/23; C07C35/27; C07D; C07D309/00; C07D309/02; C07D309/08; C07D309/10; C07D309/12
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
7 words
AN OPTICALLY ACTIVE COMPOUND OF THE FORMULA:
Claim 2
Dependent Claim
7 words
AN OPTICALLY ACTIVE COMPOUND OF THE FORMULA:
Claim 3
Dependent Claim
29 words
A compound according to claim 1 wherein R1 is hydrogen or alkyl of one to 4 carbon atoms, inclusive, or a pharmacologically acceptable salt thereof when R1 is hydrogen.
Claim 4
Dependent Claim
16 words
An optically active compound according to claim 2 wherein the side-chain hydroxy is in S configuration.
Claim 5
Dependent Claim
12 words
A compound according to claim 3 wherein R3 and R4 are hydrogen.
Claim 6
Dependent Claim
10 words
A compound according to claim 4 wherein n is 1.
Claim 7
Dependent Claim
10 words
A compound according to claim 5 wherein A is trimethylene.
Claim 8
Dependent Claim
10 words
A compound according to claim 6 wherein R2 is ethyl.
Claim 9
Dependent Claim
11 words
5,6,17,18-dehydro-PGA3, a compound according to claim 7 wherein R1 is hydrogen.
Claim 10
Dependent Claim
14 words
A compound according to claim 3 wherein R3 is methyl and R4 is hydrogen.
Claim 11
Dependent Claim
10 words
A compound according to claim 9 wherein n is 1.
Claim 12
Dependent Claim
10 words
A compound according to claim 10 wherein A is trimethylene.
Claim 13
Dependent Claim
10 words
A compound according to claim 11 wherein R2 is ethyl.
Claim 14
Dependent Claim
11 words
5,6,17,18-dehydro-15-methyl-PGA3, a compound according to claim 12 wherein R1 is hydrogen.
Claim 15
Dependent Claim
7 words
An optically active compound of the formula:
Claim 16
Dependent Claim
7 words
An optically active compound of the formula:
Claim 17
Dependent Claim
40 words
An optically active compound according to claim 14 wherein the side-chain hydroxy is in S configuration, and wherein R1 is hydrogen or alkyl of 1 to 4 carbon atoms, inclusive, or a pharmacologically acceptable salt thereof when R1 is hydrogen.
Claim 18
Dependent Claim
17 words
A compound according to claim 15 wherein R2 is ethyl, and R3 and R4 are both hydrogen.
Claim 19
Dependent Claim
10 words
A compound according to claim 16 wherein b is 1.
Claim 20
Dependent Claim
23 words
A compound according to claim 17 wherein Z is ethylene substituted with 2 fluoro on the carbon atom alpha to the carboxylate function.
Claim 21
Dependent Claim
23 words
A compound according to claim 17 wherein Z is ethylene substituted with one methyl on the carbon atom beta to the carboxylate function.
Claim 22
Dependent Claim
24 words
A compound according to claim 15 wherein R2 is ethyl, R3 is alkyl of 1 to 4 carbon atoms, inclusive, and R4 is hydrogen.
Claim 23
Dependent Claim
10 words
A compound according to claim 20 wherein b is 1.
Claim 24
Dependent Claim
23 words
A compound according to claim 21 wherein Z is ethylene substituted with 2 fluoro on the carbon atom alpha to the carboxylate function.
Claim 25
Dependent Claim
23 words
A compound according to claim 21 wherein Z is ethylene substituted with one methyl on the carbon atom beta to the carboxylate function.
References Cited (Backward Citations)
DE2118686A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-05-12 | 1978-11-11 | 1979-05-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-05-12 | 1982-11-11 | 1983-05-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-05-12 | 1986-11-11 | 1987-05-13 | $7700.00 | Window Closed / Lapsed |