Patent US5141634A successfully refreshed from Google Patents.
US5141634A
Expired / Lapsed
US
⏱️ 0.0 years remaining
High stability porous zirconium oxide spherules
Assignee: University of Minnesota System
•
Filing: 1991-02-12
•
Granted: 1992-08-25
•
Expires: 2011-02-12
Abstract
Abstract The present invention provides a stable stationary phase for chromatography which comprises porous ZrO 2 spherules coated with a cross-linked polymer coating wherein said coated spherules have a pore size from about 20-500 Å and a particle diameter range of about 0.5-500 microns, and are stable in basic media to pHs of up to about 14.
Inventors
- 👤 Peter W. Carr
- 👤 Eric F. Funkenbusch
- 👤 Martin P. Rigney
- 👤 Patrick L. Coleman
- 👤 Douglas A. Hanggi
- 👤 Wes A. Schafer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 06:59
CPC Classifications
B; B01; B01J; B01J20/00; B01J20/281; B01J20/286; B01J20/287; B01J20/02; B01J20/06; B01J20/30; B01J20/32; B01J20/3202; B01J20/3204; B01J20/3231; B01J20/3234; B01J20/3242; B01J20/3244; B01J20/3246; B01J20/3248; B01J20/3268; B01J20/328; B01J20/3282; B01J39/00; B01J39/08; B01J39/12; B82; B82Y; B82Y30/00; C; C01; C01G; C01G25/00; C01G25/02; B01J2220/00; B01J2220/50; B01J2220/54; C01P; C01P2004/00; C01P2004/30; C01P2004/32; C01P2004/60; C01P2004/61; C01P2004/62; C01P2004/64; C01P2004/80; C01P2006/00; C01P2006/12; C01P2006/14; C01P2006/16; C01P2006/17; G; G01; G01N; G01N30/00; G01N30/02; G01N30/50; G01N30/52; G01N2030/524; G01N2030/525
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
69 words
A porous ZrO 2 spherule having a diameter of about 0.5-500 microns, a surface area of about 1-200 m 2 /g, and a pore size of about 20-500 Å, wherein the spherule is substantially stable in an aqueous solution of a pH of about 1-14, and wherein the spherule further comprises a surface incorporating a surface adsorbed phosphate in an amount effective to impart cation-exchange characteristics to the spherule.
Claim 2
Dependent Claim
69 words
A porous ZrO 2 spherule having a diameter of about 0.5-500 microns, a surface area of about 1-200 m 2 /g, and a pore size of about 20-500 Å, wherein the spherule is substantially stable in an aqueous solution of a pH of about 1-14, and wherein the spherule further comprises a surface incorporating a surface adsorbed phosphate in an amount effective to impart cation-exchange characteristics to the spherule.
Claim 3
Dependent Claim
11 words
The spherule of claim 1 which comprises about 0.5-15.0 wt-% phosphate.
Claim 4
Dependent Claim
11 words
The spherule of claim 2 which comprises about 2.0-12.0 wt-% phosphate.
Claim 5
Dependent Claim
11 words
The spherule of claim 1 which comprises a surface-adsorbed inorganic phosphate.
Claim 6
Dependent Claim
20 words
The spherule of claim 4 wherein the inorganic phosphate is derived from phosphoric acid or an alkali metal phosphate salt.
Claim 7
Dependent Claim
116 words
A porous ZrO 2 spherule having a diameter of about 0.5-500 microns, a surface area of about 1-200 m 2 /g, and a pore size of about 20-500 Å, (i) wherein the spherule is substantially stable in an aqueous solution of a pH of about 1-14; (ii) wherein the spherule further comprises a surface incorporating phosphate in an amount effective to impart cation-exchange characteristics to the spherule; and (iii) wherein said spherule further comprising said surface incorporating a surface adsorbed phosphate is produced by treating the porous ZrO 2 spherule with an aqueous solution of an inorganic phosphate for a period of time and at a temperature which are effective to adsorb phosphate onto said surface.
Claim 8
Dependent Claim
116 words
A porous ZrO 2 spherule having a diameter of about 0.5-500 microns, a surface area of about 1-200 m 2 /g, and a pore size of about 20-500 Å, (i) wherein the spherule is substantially stable in an aqueous solution of a pH of about 1-14; (ii) wherein the spherule further comprises a surface incorporating phosphate in an amount effective to impart cation-exchange characteristics to the spherule; and (iii) wherein said spherule further comprising said surface incorporating a surface adsorbed phosphate is produced by treating the porous ZrO 2 spherule with an aqueous solution of an inorganic phosphate for a period of time and at a temperature which are effective to adsorb phosphate onto said surface.
Claim 9
Dependent Claim
15 words
The spherule of claim 6, wherein the inorganic phosphate is H 3 PO 4 .
Claim 10
Dependent Claim
12 words
The spherule of claim 6, wherein the temperature is about 20°-30° C.
Claim 11
Dependent Claim
20 words
The spherule of claim 6, wherein the concentration of the inorganic phosphate in the aqueous solution is about 0.01-1.00 molal.
Claim 12
Dependent Claim
14 words
The spherule of claim 6, wherein the period of time is about 1-4 hours.
Claim 13
Dependent Claim
14 words
The spherule of claim 10, wherein the period of time is about 3-4 hours.
References Cited (Backward Citations)
US2979374A
Cited
US3862908A
Cited
US3556945A
Cited
US3920865A
Cited
US3960762A
Cited
US3783101A
Cited
US3782075A
Cited
US4010242A
Cited
US3855172A
Cited
US3892678A
Cited
US3912593A
Cited
US3850751A
Cited
US3841971A
Cited
US3956179A
Cited
US3892580A
Cited
US3910851A
Cited
US4673734A
Cited
US4389385A
Cited
US4330440A
Cited
US4334972A
Cited
US4138336A
Cited
US4209554A
Cited
US4298500A
Cited
US4386010A
Cited
US4376064A
Cited
US4699717A
Cited
US4517241A
Cited
US4648975A
Cited
US4520122A
Cited
EP0162716A2
Cited
US4600646A
Cited
US4544485A
Cited
EP0216730A2
Cited
JPS63123817A
Cited
EP0273756A2
Cited
US4871711A
Cited
EP0280673A2
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-08-25 | 1996-02-24 | 1996-08-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-08-25 | 2000-02-24 | 2000-08-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-08-25 | 2004-02-24 | 2004-08-25 | $7700.00 | Window Closed / Lapsed |