US5141634A
Expired / Lapsed
US
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High stability porous zirconium oxide spherules
Assignee: University of Minnesota System
•
Filing: 1991-02-12
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Granted: 1992-08-25
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Expires: 2011-02-12
Abstract
Abstract The present invention provides a stable stationary phase for chromatography which comprises porous ZrO 2 spherules coated with a cross-linked polymer coating wherein said coated spherules have a pore size from about 20-500 Å and a particle diameter range of about 0.5-500 microns, and are stable in basic media to pHs of up to about 14.
Inventors
- 👤 Peter W. Carr
- 👤 Eric F. Funkenbusch
- 👤 Martin P. Rigney
- 👤 Patrick L. Coleman
- 👤 Douglas A. Hanggi
- 👤 Wes A. Schafer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 05:41
CPC Classifications
B; B01; B01J; B01J20/00; B01J20/281; B01J20/286; B01J20/287; B01J20/02; B01J20/06; B01J20/30; B01J20/32; B01J20/3202; B01J20/3204; B01J20/3231; B01J20/3234; B01J20/3242; B01J20/3244; B01J20/3246; B01J20/3248; B01J20/3268; B01J20/328; B01J20/3282; B01J39/00; B01J39/08; B01J39/12; B82; B82Y; B82Y30/00; C; C01; C01G; C01G25/00; C01G25/02; B01J2220/00; B01J2220/50; B01J2220/54; C01P; C01P2004/00; C01P2004/30; C01P2004/32; C01P2004/60; C01P2004/61; C01P2004/62; C01P2004/64; C01P2004/80; C01P2006/00; C01P2006/12; C01P2006/14; C01P2006/16; C01P2006/17; G; G01; G01N; G01N30/00; G01N30/02; G01N30/50; G01N30/52; G01N2030/524; G01N2030/525
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
69 words
A porous ZrO 2 spherule having a diameter of about 0.5-500 microns, a surface area of about 1-200 m 2 /g, and a pore size of about 20-500 Å, wherein the spherule is substantially stable in an aqueous solution of a pH of about 1-14, and wherein the spherule further comprises a surface incorporating a surface adsorbed phosphate in an amount effective to impart cation-exchange characteristics to the spherule.
Claim 2
Dependent Claim
69 words
A porous ZrO 2 spherule having a diameter of about 0.5-500 microns, a surface area of about 1-200 m 2 /g, and a pore size of about 20-500 Å, wherein the spherule is substantially stable in an aqueous solution of a pH of about 1-14, and wherein the spherule further comprises a surface incorporating a surface adsorbed phosphate in an amount effective to impart cation-exchange characteristics to the spherule.
Claim 3
Dependent Claim
11 words
The spherule of claim 1 which comprises about 0.5-15.0 wt-% phosphate.
Claim 4
Dependent Claim
11 words
The spherule of claim 2 which comprises about 2.0-12.0 wt-% phosphate.
Claim 5
Dependent Claim
11 words
The spherule of claim 1 which comprises a surface-adsorbed inorganic phosphate.
Claim 6
Dependent Claim
20 words
The spherule of claim 4 wherein the inorganic phosphate is derived from phosphoric acid or an alkali metal phosphate salt.
Claim 7
Dependent Claim
116 words
A porous ZrO 2 spherule having a diameter of about 0.5-500 microns, a surface area of about 1-200 m 2 /g, and a pore size of about 20-500 Å, (i) wherein the spherule is substantially stable in an aqueous solution of a pH of about 1-14; (ii) wherein the spherule further comprises a surface incorporating phosphate in an amount effective to impart cation-exchange characteristics to the spherule; and (iii) wherein said spherule further comprising said surface incorporating a surface adsorbed phosphate is produced by treating the porous ZrO 2 spherule with an aqueous solution of an inorganic phosphate for a period of time and at a temperature which are effective to adsorb phosphate onto said surface.
Claim 8
Dependent Claim
116 words
A porous ZrO 2 spherule having a diameter of about 0.5-500 microns, a surface area of about 1-200 m 2 /g, and a pore size of about 20-500 Å, (i) wherein the spherule is substantially stable in an aqueous solution of a pH of about 1-14; (ii) wherein the spherule further comprises a surface incorporating phosphate in an amount effective to impart cation-exchange characteristics to the spherule; and (iii) wherein said spherule further comprising said surface incorporating a surface adsorbed phosphate is produced by treating the porous ZrO 2 spherule with an aqueous solution of an inorganic phosphate for a period of time and at a temperature which are effective to adsorb phosphate onto said surface.
Claim 9
Dependent Claim
15 words
The spherule of claim 6, wherein the inorganic phosphate is H 3 PO 4 .
Claim 10
Dependent Claim
12 words
The spherule of claim 6, wherein the temperature is about 20°-30° C.
Claim 11
Dependent Claim
20 words
The spherule of claim 6, wherein the concentration of the inorganic phosphate in the aqueous solution is about 0.01-1.00 molal.
Claim 12
Dependent Claim
14 words
The spherule of claim 6, wherein the period of time is about 1-4 hours.
Claim 13
Dependent Claim
14 words
The spherule of claim 10, wherein the period of time is about 3-4 hours.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-08-25 | 1996-02-24 | 1996-08-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-08-25 | 2000-02-24 | 2000-08-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-08-25 | 2004-02-24 | 2004-08-25 | $7700.00 | Window Closed / Lapsed |