Patent US5261459A successfully refreshed from Google Patents.
Patent US5077036A successfully refreshed from Google Patents.
US5077036A
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Biocompatible stable fluorocarbon emulsions for contrast enhancement and oxygen transport comprising 40-125% wt./volume fluorocarbon combined with a phospholipid
Assignee: PFC Therapeutics LLC
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Filing: 1990-03-30
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Granted: 1991-12-31
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Expires: 2010-03-30
Abstract
Abstract Biocompatible fluorcarbon emulsions having fluorocarbon in concentrations of from 75% weight per volume to 125% weight per volume have small, biocompatible particle size stability through heat sterilization with one emulsifying agent, including phospholipids, in concentrations of from 3% to 7% weight per volume. The single emulsifying agent can be hydrogenated lecithins and synthesized lecithins. Fluorocarbon emulsions having fluorocarbon in concentrations of from 40% weight per volume to 125% weight per volume have stability of partial pressure of oxygen and of partial pressure of carbon dioxide through heat sterilization and storage for extended periods of time after having been oxygenated with dissolved oxygen.
Inventors
- 👤 David M. Long, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 14:47
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026; A61K31/00; A61K31/02; Y; Y10; Y10S; Y10S977/00; Y10S977/902; Y10S977/904; Y10S977/915; Y10S977/927
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
37 words
A fluorocarbon emulsion comprising a continuous aqueous phase, a fluorocarbon in an amount of from 40% to 125% weight per volume, and an effective amount of an emulsifying agent comprising a phospholipid with substantially saturated carbon bonds.
Claim 2
Dependent Claim
37 words
A fluorocarbon emulsion comprising a continuous aqueous phase, a fluorocarbon in an amount of from 40% to 125% weight per volume, and an effective amount of an emulsifying agent comprising a phospholipid with substantially saturated carbon bonds.
Claim 3
Dependent Claim
12 words
The emulsion of claim 1, wherein said fluorocarbon comprises a mono-brominated fluorocarbon.
Claim 4
Dependent Claim
14 words
The emulsion of claim 1, wherein said fluorocarbon comprises a perfluoroalkylated ether or polyether.
Claim 5
Dependent Claim
12 words
The emulsion of claim 1, wherein said fluorocarbon comprises a fluorocarbon-hydrocarbon compound.
Claim 6
Dependent Claim
29 words
The emulsion of claim 1 having a fluorocarbon concentration of more than 50% weight per volume, and an emulsifying agent in concentration of less than 7% weight per volume.
Claim 7
Dependent Claim
29 words
The emulsion of claim 1 having a fluorocarbon concentration of more than 50% weight per volume, and an emulsifying agent in concentration of less than 5% weight per volume.
Claim 8
Dependent Claim
22 words
The emulsion of claims 5 or 6, wherein said emulsifying agent is in a concentration of more than 3.5% weight per volume.
Claim 9
Dependent Claim
11 words
The emulsion of claims 1, 4 having a substantially stable pH.
Claim 10
Dependent Claim
16 words
The emulsion of any one of claims 1, 4, wherein said phospholipid is a synthesized lecithin.
Claim 11
Dependent Claim
10 words
The emulsion of claim 9, wherein said phospholipid is 1,2-dimyristoyl-sn-glycero-phosphocholine.
Claim 12
Dependent Claim
10 words
The emulsion of claim 9, wherein said phospholipid is 1,2-dipalmitoyl-sn-glycero-phosphocholine.
Claim 13
Dependent Claim
17 words
The emulsion of any one of claims 1, 4, wherein said phospholipid is a hydrogenated soybean lecithin.
Claim 14
Dependent Claim
18 words
The emulsion of any one of claims 1, 4, wherein said phospholipid is a hydrogenated egg yolk lecithin.
Claim 15
Dependent Claim
26 words
The emulsion of any one of claims 1 4, wherein the fluorocarbon in the emulsion has a mean particle size of less than approximately 250 nanometers.
Claim 16
Dependent Claim
26 words
The emulsion of any one of claims 1, 4, having a fluorocarbon phase formed of particles, which particles exhibit substantial particle size stability through heat sterilization.
Claim 17
Dependent Claim
17 words
The emulsion of any one of claims 1, 4, having a viscosity compatible with whole human blood.
Claim 18
Dependent Claim
20 words
The emulsion of any one of claims 1, 4, having a viscosity biologically compatible for intravascular use in an animal.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-12-30 | 1995-07-01 | 1995-12-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-12-30 | 1999-07-01 | 1999-12-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-12-30 | 2003-07-01 | 2003-12-31 | $7700.00 | Window Closed / Lapsed |