US4917878A
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Novel use of a radiolabelled antibody against stage specific embryonic antigen for the detection of occult abscesses in mammals
Assignee: Thomas Jefferson University
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Filing: 1988-05-02
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Granted: 1990-04-17
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Expires: 2008-05-02
Abstract
Abstract The invention discloses improved reagents containing antibodies against stage specific embryonic antigen-1 antibodies and improved methods for detection of occult abscess and inflammation using the improved reagents.
Inventors
- 👤 Madhukar L. Thakur
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 15:34
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/08; A61K51/10; A61K51/1093; A61K2123/00
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
67 words
A method of detecting occult abscess and inflammation in a mammal, comprising the steps: administering to the mammal an effective amount of a reagent comprising an antibody against stage specific embryonic antigen-1, a radiolabel and a bifunctional chelating agent which links said antibody and said radiolabel under conditions which allow the reagent to accumulate at sites of occult abscess; and detecting said occult abscess by radioscintigraphic method.
Claim 2
Independent Claim
67 words
A method of detecting occult abscess and inflammation in a mammal, comprising the steps: administering to the mammal an effective amount of a reagent comprising an antibody against stage specific embryonic antigen-1, a radiolabel and a bifunctional chelating agent which links said antibody and said radiolabel under conditions which allow the reagent to accumulate at sites of occult abscess; and detecting said occult abscess by radioscintigraphic method.
Claim 3
Dependent Claim
16 words
The method of claim 1 wherein said bifunctional chelating agent is cyclic anhydride of diethylenetriaminepentaacetic acid.
Claim 4
Dependent Claim
11 words
The method of claim 1 wherein radiographic method is scintillation scanning.
Claim 5
Dependent Claim
30 words
The method of claim 1 wherein said radiolabel is 111 Indium, 99m Technetium, 67 Gallium, 68 Gallium, 97 Ruthenium, 123 Iodine, 90 Yttrium, 203 Lead, 67 Copper or 111m Indium.
Claim 6
Dependent Claim
14 words
The method of claim 4 wherein said radiolabel is 111 Indium or 99m Technetium.
Claim 7
Independent Claim
77 words
A method of detecting occult abscess and inflammation in a mammal wherein a reagent containing a radiolabeled antibody is administered in an effective amount to the mammal, the reagent is allowed to accumulate at the site of the abscess and the radiolabel is then detected by radiographic method, in which method a reagent comprising an antibody against stage specific embryonic antigen-1, a radiolabel and a bifunctional chelating agent to link said antibody and said radiolabel is used.
Claim 8
Independent Claim
77 words
A method of detecting occult abscess and inflammation in a mammal wherein a reagent containing a radiolabeled antibody is administered in an effective amount to the mammal, the reagent is allowed to accumulate at the site of the abscess and the radiolabel is then detected by radiographic method, in which method a reagent comprising an antibody against stage specific embryonic antigen-1, a radiolabel and a bifunctional chelating agent to link said antibody and said radiolabel is used.
Claim 9
Dependent Claim
17 words
The method of claim 6 wherein said bifunctional chelating agent is cyclic anhydride of diethylene triaminepentaacetic acid.
Claim 10
Dependent Claim
30 words
The method of claim 6 wherein said radiolabel is 111 Indium, 99m Technetium, 67 Gallium, 68 Gallium, 97 Ruthenium, 123 Iodine, 90 Yttrium, 203 Lead, 67 Copper or 111m Indium.
Claim 11
Dependent Claim
14 words
The method of claim 8 wherein said radiolabel is 111 Indium or 99m Technetium.
Claim 12
Independent Claim
67 words
A method of detecting occult abscess and inflammation in a mammal wherein a reagent containing an antibody linked to a chelating agent and a radiolabel is administered in an effective amount to the mammal, the reagent is allowed to accumulate at the side of the abscess and the radiolabel is then detected by radiographic method, in which method an antibody against stage specific embryonic antigen-1 is used.
Claim 13
Independent Claim
67 words
A method of detecting occult abscess and inflammation in a mammal wherein a reagent containing an antibody linked to a chelating agent and a radiolabel is administered in an effective amount to the mammal, the reagent is allowed to accumulate at the side of the abscess and the radiolabel is then detected by radiographic method, in which method an antibody against stage specific embryonic antigen-1 is used.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1993-04-16 | 1993-10-16 | 1994-04-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-04-16 | 1997-10-16 | 1998-04-17 | $3760.00 | Window Closed / Lapsed |
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