US4622420A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Chelating agents and method
Assignee: University of California, San Diego
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Filing: 1985-02-05
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Granted: 1986-11-11
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Expires: 2005-02-05
Abstract
Abstract A simple method for making EDTA, ED3A or DTPA analogs from amide derivatives of alpha amino acids is disclosed. These EDTA, ED3A or DTPA analogs are useful chelating agents, and preferably are useful as bifunctional chelating agents which may be attached to biological molecules and which form physiologically stable chelates with a variety of metal ions.
Inventors
- 👤 Claude F. Meares
- 👤 Simon M. Yeh
- 👤 David G. Sherman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 02:36
CPC Classifications
C; C11; C11D; C11D3/00; C11D3/16; C11D3/26; C11D3/33; A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0474; A61K51/0478; A61K2123/00; Y; Y10; Y10S; Y10S534/00; Y10S534/08
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
85 words
An optically active and substantially optically pure chelating agent comprising: an EDTA, ED3A, or DTPA analog having a central ethylene moiety, said ethylene moiety being substituted at a one carbon thereof by an R moiety substituent, said R moiety substituent being an amino acid side group including a methylene group through which said amino acid side group is bonded, and selected from the group consisting of ##STR10## said one carbon defining an L or D stereochemical configuration for said EDTA, ED3A or said DTPA analog.
Claim 2
Dependent Claim
85 words
An optically active and substantially optically pure chelating agent comprising: an EDTA, ED3A, or DTPA analog having a central ethylene moiety, said ethylene moiety being substituted at a one carbon thereof by an R moiety substituent, said R moiety substituent being an amino acid side group including a methylene group through which said amino acid side group is bonded, and selected from the group consisting of ##STR10## said one carbon defining an L or D stereochemical configuration for said EDTA, ED3A or said DTPA analog.
Claim 3
Dependent Claim
9 words
A chelating agent having the structure ##STR11## wherein ##STR12##
Claim 4
Dependent Claim
9 words
A chelating agent having the structure ##STR11## wherein ##STR12##
Claim 5
Dependent Claim
62 words
An optically active and substantially optically pure chelating agent having the structure ##STR13## wherein R 1 is --CH 2 COOH, --CH 2 CH 2 OH, or --CH 2 CH 2 N(CH 2 COOH) 2 and R is an alpha amino acid side group selected from the group consisting of leucine, phenylalanine, tryptophan, methionine, serine, cysteine, tyrosine, methyl tyrosine, methyl tryptophan, and p-nitrophenylalanine.
Claim 6
Dependent Claim
62 words
An optically active and substantially optically pure chelating agent having the structure ##STR13## wherein R 1 is --CH 2 COOH, --CH 2 CH 2 OH, or --CH 2 CH 2 N(CH 2 COOH) 2 and R is an alpha amino acid side group selected from the group consisting of leucine, phenylalanine, tryptophan, methionine, serine, cysteine, tyrosine, methyl tyrosine, methyl tryptophan, and p-nitrophenylalanine.
Claim 7
Dependent Claim
55 words
An optically active and substantially optically pure chelating agent having the structure ##STR14## wherein R 1 is --CH 2 CO 2 H, CH 2 CH 2 OH, or --CH 2 CH 2 N(CH 2 COOH) 2 , and R 2 is selected from the group consisting of --OH, NH 2 , and --NO 2 .
Claim 8
Dependent Claim
55 words
An optically active and substantially optically pure chelating agent having the structure ##STR14## wherein R 1 is --CH 2 CO 2 H, CH 2 CH 2 OH, or --CH 2 CH 2 N(CH 2 COOH) 2 , and R 2 is selected from the group consisting of --OH, NH 2 , and --NO 2 .
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-11-10 | 1990-05-12 | 1990-11-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-11-10 | 1994-05-12 | 1994-11-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-11-10 | 1998-05-12 | 1998-11-11 | $7700.00 | Window Closed / Lapsed |