US4575556A
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Bifunctional chelating agents
Assignee: Medi Physics Inc
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Filing: 1983-11-28
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Granted: 1986-03-11
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Expires: 2003-11-28
Abstract
Abstract Novel homocysteine thiolactone bifunctional chelating agents useful for chelating radionuclides to produce a radiodiagnostic agent for use in in vivo imaging and a method for producing this chelating agent.
Inventors
- 👤 Edmund F. Byrne
- 👤 Glen L. Tolman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 15:08
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0474; A61K51/0478; A61K2123/00
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
88 words
A compound of the formula: ##STR10## wherein R is hydrogen or lower alkyl; R 1 and R 2 are individually hydrogen or lower alkyl or taken together form oxo; R 3 is an amino protecting group where R 1 and R 2 are individually hydrogen or lower alkyl; R 3 is hydrogen when R 1 and R 2 taken together form oxo; R 4 is hydrogen or lower alkyl, R 5 is hydrogen or a thiol protecting group; and x and y are integers from 0 to 2.
Claim 2
Dependent Claim
88 words
A compound of the formula: ##STR10## wherein R is hydrogen or lower alkyl; R 1 and R 2 are individually hydrogen or lower alkyl or taken together form oxo; R 3 is an amino protecting group where R 1 and R 2 are individually hydrogen or lower alkyl; R 3 is hydrogen when R 1 and R 2 taken together form oxo; R 4 is hydrogen or lower alkyl, R 5 is hydrogen or a thiol protecting group; and x and y are integers from 0 to 2.
Claim 3
Dependent Claim
13 words
The compound of claim 1 wherein said compound is N-(t-butyloxycarbonyl), N-(2-mercaptoethyl)glycyl homocysteine thiolactone.
Claim 4
Dependent Claim
12 words
The compound of claim 1 wherein said compound is N-[2-(S-acetamidomethyl)mercaptopropionyl]glycyl homocysteine thiolactone.
Claim 5
Dependent Claim
12 words
The compound of claim 1 wherein said compound is N-[2-(S-benzamidomethyl)mercaptopropionyl]glycyl homocysteine thiolactone.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-03-10 | 1989-09-09 | 1990-03-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-03-10 | 1993-09-09 | 1994-03-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-03-10 | 1997-09-09 | 1998-03-11 | $7700.00 | Window Closed / Lapsed |