US4913812A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Active support substance and adsorbent for chromatography
Assignee: Resonac Holdings Corp
•
Filing: 1988-12-29
•
Granted: 1990-04-03
•
Expires: 2008-12-29
Abstract
Abstract The active support substance and the adsorbent for chromatography, which have got all of the properties desired for affinity chromatography, can be constituted by a porous copolymer comprising gel copolymer which is principally composed of (A) a glycidyl monovinylester or glycidyl monovinylether and (B) alkyleneglycol divinylester, and combination groups to be bound to ligands through a covalent bond, the (A) component being crosslinked by the (B) component, and the combination groups being bound to epoxy groups of the (A) component.
Inventors
- 👤 Soyao Moriguchi
- 👤 Yoshito Nakayama
- 👤 Hiroshi Suzuki
- 👤 Tae Ishii
- 👤 Seiji Shioda
- 👤 Isao Kaiho
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 04:25
CPC Classifications
C; C08; C08F; C08F8/00; B; B01; B01J; B01J20/00; B01J20/22; B01J20/26; B01J20/265; B01J20/267; B01J20/281; B01J20/286
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
117 words
An adsorbent for chromatography which is a porous copolymer comprising a gel copolymer having particles sized and dimensioned to effect chromatographic separation which is principally composed of (A) a glycidyl monovinylester or glycidyl monovinylether and (B) alkyleneglycol divinylester, a combination group bound to the epoxy group of the (A) component and a ligand bound through a covalent bond to the combination group, the combination group being formed by binding an aminocarboxylic acid having a hydroxyl group to the epoxy group of said gel copolymer or the glycidyl group of a modified gel copolymer obtained by binding a glycidyl group-containing compound to the hydroxyl group formed by ring-opening with water of the epoxy group of said gel copolymer.
Claim 2
Dependent Claim
117 words
An adsorbent for chromatography which is a porous copolymer comprising a gel copolymer having particles sized and dimensioned to effect chromatographic separation which is principally composed of (A) a glycidyl monovinylester or glycidyl monovinylether and (B) alkyleneglycol divinylester, a combination group bound to the epoxy group of the (A) component and a ligand bound through a covalent bond to the combination group, the combination group being formed by binding an aminocarboxylic acid having a hydroxyl group to the epoxy group of said gel copolymer or the glycidyl group of a modified gel copolymer obtained by binding a glycidyl group-containing compound to the hydroxyl group formed by ring-opening with water of the epoxy group of said gel copolymer.
Claim 3
Dependent Claim
13 words
The adsorbent as claimed in claim 1, in which said ligand is lectin.
Claim 4
Dependent Claim
13 words
The adsorbent as claimed in claim 1, in which said ligand is heparin.
Claim 5
Dependent Claim
14 words
The adsorbent as claimed in claim 1, in which said ligand is protein A.
Claim 6
Dependent Claim
14 words
The adsorbent as claimed in claim 1, in which said ligand is serum albumin.
Claim 7
Dependent Claim
14 words
The adsorbent as claimed in claim 1, in which said ligand is triazine dyestuff.
Claim 8
Dependent Claim
13 words
The adsorbent as claimed in claim 1, in which said ligand is acriflavine.
Claim 9
Dependent Claim
14 words
The adsorbent as claimed in claim 1, in which said ligand is iminodiacetic acid.
Claim 10
Dependent Claim
14 words
The adsorbent as claimed in claim 1, in which said ligand is phenylboric acid.
Claim 11
Dependent Claim
15 words
The adsorbent as claimed in claim 1, in which said ligand is ethylenediamine diacetic acid.
Claim 12
Dependent Claim
13 words
The adsorbent as claimed in claim 1, in which said ligand is biotin.
Claim 13
Dependent Claim
14 words
The adsorbent as claimed in claim 1, in which said ligand is N-acetyl glucosamine.
References Cited (Backward Citations)
GB1431940A
Cited
US3960720A
Cited
US3917527A
Cited
US3873514A
Cited
US4089823A
Cited
US4118347A
Cited
GB1566647A
Cited
GB1577270A
Cited
US4330440A
Cited
GB2048896A
Cited
US4421650A
Cited
EP0054249A1
Cited
EP0054685A2
Cited
US4415700A
Cited
US4468330A
Cited
US4431546A
Cited
US4431544A
Cited
EP0066209A1
Cited
US4604207A
Cited
US4512898A
Cited
US4577013A
Cited
US4565832A
Cited
US4693985A
Cited
US4544485A
Cited
GB2168357A
Cited
JPH06187652A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-04-02 | 1993-10-02 | 1994-04-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-04-02 | 1997-10-02 | 1998-04-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-04-02 | 2001-10-02 | 2002-04-03 | $7700.00 | Window Closed / Lapsed |