US4871350A
Expired / Lapsed
US
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Methods and compositions for preventing secondary cataracts
Assignee: HOUSTON BIOTECHNOLOGY INCORPORATED 3606 RESEARCH FOREST DRIVE WOODLANDS TEXAS 77381 A DE CORP
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Filing: 1988-06-08
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Granted: 1989-10-03
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Expires: 2008-06-08
Abstract
Abstract Novel methods and compositions are provided for preventing secondary cataracts. A cytotoxic agent is employed which is introduced into the anterior chamber of the eye to inhibit proliferation of remnant lens epithelial cells after extracapsular cataract extraction. Desirably a non-cytotoxic agent cross-reactive with the cytotoxic agent is introduced prior to introduction of the cytotoxic agent. The agents can be provided as kits.
Inventors
- 👤 Dominic M-K. Lam
- 👤 Peter J. Kelleher
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 03:54
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/18; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/68; A61K47/6801; A61K47/6803; A61K47/6811; A61K47/6817; A61K47/6819; A61K47/6825; A61K47/6827; A61K47/6835; A61K47/6843; A61K47/6845; A61K38/00
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
80 words
A method for inhibiting posterior lens capsule opacification after extracapsular cataract extraction, said method comprising: introducing, in conjunction with extracapsular cataract extraction, into the anterior chamber of the eye in an amount sufficient to inhibit proliferation of lens epithelial cells, a cytotoxic agent capable of binding to said epthelial cells and killing the cells without additional agents, wherein said cytotoxic agent comprises a monoclonal antibody or fragment thereof conjugated to a toxin molecule or cytotoxic moiety of a toxin molecule.
Claim 2
Independent Claim
80 words
A method for inhibiting posterior lens capsule opacification after extracapsular cataract extraction, said method comprising: introducing, in conjunction with extracapsular cataract extraction, into the anterior chamber of the eye in an amount sufficient to inhibit proliferation of lens epithelial cells, a cytotoxic agent capable of binding to said epthelial cells and killing the cells without additional agents, wherein said cytotoxic agent comprises a monoclonal antibody or fragment thereof conjugated to a toxin molecule or cytotoxic moiety of a toxin molecule.
Claim 3
Dependent Claim
23 words
A method according to claim 1, wherein said cytotoxic moiety is the ricin A chain, abrin A chain, or diphtheria toxin A chain.
Claim 4
Dependent Claim
11 words
A method according to claim 1, wherein said toxin is saporin.
Claim 5
Dependent Claim
19 words
A method according to claim 1, wherein said introducing comprises injecting said cytotoxic agent into the lens capsule area.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-10-02 | 1993-04-03 | 1993-10-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-10-02 | 1997-04-03 | 1997-10-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-10-02 | 2001-04-03 | 2001-10-03 | $7700.00 | Window Closed / Lapsed |