US4665089A
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Process for preventing or reversing cataract formation using protein modification reagents
Assignee: Massachusetts Institute of Technology
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Filing: 1985-03-21
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Granted: 1987-05-12
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Expires: 2005-03-21
Abstract
Abstract Cataract in mammalian lenses can be prevented or reversed by applying a solution of an imidoester, a N-hydroxysuccinimide-ester or hydrogen peroxide to the lens under conditions that permit the solution to interact with the lens constituents.
Inventors
- 👤 Roelant J. Siezen
- 👤 Christophe M. Coppin
- 👤 George B. Benedek
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 15:45
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/21; A61K31/215; A61K31/22; A61K31/225; A61K31/33; A61K31/395; A61K31/40; A61K33/00; A61K33/40
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
82 words
A method of preventing or reversing cataract formation in the lens of the eye which comprises: administering a therapeutically effective amount of a physiologically acceptable solution of a reagent to the lens, said reagent being selected from the group consisting of an imido-ester having the formula ##STR16## wherein R represents the remainder of the reagent molecule and n is at least 1, an N-hydroxy-succinimide ester having the formula ##STR17## wherein R represents the remainder of the reagent molecule, and a mixture thereof.
Claim 2
Independent Claim
82 words
A method of preventing or reversing cataract formation in the lens of the eye which comprises: administering a therapeutically effective amount of a physiologically acceptable solution of a reagent to the lens, said reagent being selected from the group consisting of an imido-ester having the formula ##STR16## wherein R represents the remainder of the reagent molecule and n is at least 1, an N-hydroxy-succinimide ester having the formula ##STR17## wherein R represents the remainder of the reagent molecule, and a mixture thereof.
Claim 3
Dependent Claim
11 words
The method of claim 1 wherein the reagent is an imido-ester.
Claim 4
Dependent Claim
12 words
The method of claim 1 wherein the reagent is an N-hydroxy-succinimide ester.
Claim 5
Dependent Claim
10 words
The method of claim 2 wherein the imido-ester comprises methyl-acetimidate.
Claim 6
Dependent Claim
10 words
The method of claim 2 wherein the imido-ester comprises ethyl-acetimidate.
Claim 7
Dependent Claim
10 words
The method of claim 2 wherein the imido-ester comprises dimethyl-adipimidate.
Claim 8
Dependent Claim
10 words
The method of claim 2 wherein the imido-ester comprises dimethyl-suberimidate.
Claim 9
Dependent Claim
10 words
The method of claim 2 wherein the imido-ester comprises dimethyl-3,3'-dithiobispropionimidate.
Claim 10
Dependent Claim
11 words
The method of claim 3 wherein the reagent is dithiobissuccinimidyl propionate.
Claim 11
Dependent Claim
11 words
The methiod of claim 3 wherein the reagent is disuccinimidyl tartrate.
Claim 12
Dependent Claim
12 words
The method of claim 3 wherein the reagent is ethylene glycol-bis(succinimidyl succinate).
Claim 13
Dependent Claim
11 words
The method of claim 3 wherein the reagent is disuccinimidyl suberate.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-05-11 | 1990-11-10 | 1991-05-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-05-11 | 1994-11-10 | 1995-05-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-05-11 | 1998-11-10 | 1999-05-12 | $7700.00 | Window Closed / Lapsed |