Method of inhibiting cataracts by topical application of a 2-substituted 1,2-benzisoselenazol-3(2H)-one

Abstract

Abstract A method of inhibiting cataract formation occasioned by the oxidative cross-linking of proteinaceous material in the lens fiber of the eye of a mammal comprising the topical administration of an effective antioxidant amount, to the eye of said mammal in need of the same, of a compound of the formula: ##STR1## wherein R is phenyl or phenyl substituted lower alkyl, the phenyl group of each being unsubstituted or substituted by halo, lower alkyl, lower alkoxy, trifluoromethyl, nitro, di-loweralkylamino, cyano, carboxy, methylenedioxy, loweralkoxycarbonyl, carboxyloweralkyl, or loweralkoxycarbonyl-lower alkyl, or R is cycloalkyl of 5 to 10 carbon atoms; and R 1 and R 2 are independently hydrogen, halo, lower alkyl, lower alkoxy, hydroxy, trifluoromethyl, or nitro or R 1 and R 2 taken together are methylenedioxy.

Inventors

• 👤 William D. Cash

Bibliographic Details