US4657930A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Mitotic inhibitors preventing posterior lens capsule opacification
Assignee: Baylor College of Medicine
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Filing: 1985-03-06
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Granted: 1987-04-14
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Expires: 2005-03-06
Abstract
Abstract Disclosed are mitotic inhibitors effective for and methods of preventing posterior lens capsule opacification after extracapsular extraction. The mitotic inhibitors comprise osmotically balanced solutions containing either methotrexate or retinoic acid, or both, in at least the minimal effective dosage at the end of one lens epithelial cell cycle. The mitotic inhibitors are instilled in the anterior chamber of the eye preferably immediately after the lens has been removed.
Inventors
- 👤 Jared M. Emery
- 👤 Raymond Y. Chan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 22:19
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/19; A61K31/20; A61K31/33; A61K31/395; A61K31/495; A61K31/505
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
44 words
A mitotic inhibitor effective to prevent proliferation of remnant lens epithelial cells when intraocularly instilled into the anterior chamber of the eye after extracapsular extraction comprising, an osmotically balanced solution containing a minimum concentration of 0.033 mg of retinoic acid per cc of solution.
Claim 2
Dependent Claim
44 words
A mitotic inhibitor effective to prevent proliferation of remnant lens epithelial cells when intraocularly instilled into the anterior chamber of the eye after extracapsular extraction comprising, an osmotically balanced solution containing a minimum concentration of 0.033 mg of retinoic acid per cc of solution.
Claim 3
Independent Claim
50 words
A method of preventing proliferation of remnant lens epithelial cells after extracapsular cataract extraction comprising, intraocularly instilling into the anterior chamber of the eye after the extracapsular extraction a mitotic inhibitor comprising an osmotically balanced solution containing a minimum concentration of 0.033 mg of retinoic acid per cc of solution.
Claim 4
Independent Claim
50 words
A method of preventing proliferation of remnant lens epithelial cells after extracapsular cataract extraction comprising, intraocularly instilling into the anterior chamber of the eye after the extracapsular extraction a mitotic inhibitor comprising an osmotically balanced solution containing a minimum concentration of 0.033 mg of retinoic acid per cc of solution.
Claim 5
Dependent Claim
28 words
A method of preventing proliferation of remnant lens epithelial cells after extracapsular cataract extraction comprising, intraocularly instilling the mitotic inhibitor of claim 2 immediately following the cataract extraction.
References Cited (Backward Citations)
US3089823A
Cited
GB1431841A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-04-13 | 1990-10-13 | 1991-04-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-04-13 | 1994-10-13 | 1995-04-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-04-13 | 1998-10-13 | 1999-04-14 | $7700.00 | Window Closed / Lapsed |