US4867984A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Drug in bead form and process for preparing same
Assignee: NAGIN K PATEL
•
Filing: 1989-02-17
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Granted: 1989-09-19
•
Expires: 2009-02-17
Abstract
Abstract A bead of a drug such as aspirin or acetaminophen formed from a small spheriodal seed particle of the drug or of an inert material coated with an adhesive and layers of drug particles likewise adhered by said adhesive, is provided. The beads may be rendered suitable for time release by coating a plurality of said beads. An 8-12% polyvinylpyrrolidone (PVP) solution may be used as the adhesive, the PVP complexing with aspirin and acetaminophen to reduce irritation of the user. Additionally, a method for manufacturing a drug in small beads having time releasae properties is also provided.
Inventors
- 👤 Nagin K. Patel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 16:26
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5073; A61K9/5078; A61K9/5084
Claims Analysis
Total Claims: 40
Claim 1
Independent Claim
93 words
An aspirin product comprising a plurality of beads not compressed into a tablet, each bead being formed of a central, small, essentially spheroidal seed and successive layers formed from powdered aspirin substantially complexed with the polyvinylpyrrolidone in an adhesive comprising from about an 8 to about a 12% solution of polyvinylpyrrolidone in alcohol, each successive layer of the substantially complexed aspirin and polyvinylpyrrolidone being adhered to the seed or to the preceeding layer by the adhesive, the bead including at least 50% by weight of aspirin, whereby the aspirin product reduces gastric irritation.
Claim 2
Dependent Claim
93 words
An aspirin product comprising a plurality of beads not compressed into a tablet, each bead being formed of a central, small, essentially spheroidal seed and successive layers formed from powdered aspirin substantially complexed with the polyvinylpyrrolidone in an adhesive comprising from about an 8 to about a 12% solution of polyvinylpyrrolidone in alcohol, each successive layer of the substantially complexed aspirin and polyvinylpyrrolidone being adhered to the seed or to the preceeding layer by the adhesive, the bead including at least 50% by weight of aspirin, whereby the aspirin product reduces gastric irritation.
Claim 3
Dependent Claim
21 words
The aspirin product of claim 1, wherein the seed is formed of pharmacologically inert material formed into an essentially spheroidal particle.
Claim 4
Dependent Claim
21 words
The aspirin product of claim 2, wherein the seed material is selected from the group including potassium chloride and microcrystalline cellulose.
Claim 5
Dependent Claim
13 words
The aspirin product of claim 1, wherein the seed is formed of aspirin.
Claim 6
Dependent Claim
19 words
The aspirin product as recited in claim 1, wherein the bead is coated with a suitable time release material.
Claim 7
Dependent Claim
32 words
The aspirin product as recited in claim 5, wherein the time release material includes a material selected from the group including ethylcellulose "pseudolatex", an aqueous anionic polymer and an alcoholic anionic polymer.
Claim 8
Dependent Claim
19 words
The aspirin product as recited in claims 1, wherein the bead includes at least 90% by weight of aspirin.
Claim 9
Dependent Claim
19 words
The aspirin product as recited in claims 1, and including a plurality of said beads encapsulated in a capsule.
Claim 10
Dependent Claim
22 words
The aspirin product as recited in claim 8, wherein the capsule is selected from the group including zero and A sized capsules.
Claim 11
Dependent Claim
24 words
The aspirin product as recited in claim 9, wherein at least a portion of the beads are coated with a suitable time release material.
Claim 12
Dependent Claim
85 words
An acetaminophen product comprising a plurality of beads not compressed into a tablet, each bead being formed of a central, small, essentially spheroidal seed and successive layers formed from powdered acetaminophen substantially complexed with the polyvinylpyrrolidone in an adhesive comprising from about an 8 to about 12% solution of polyvinylpyrrolidone in alcohol, each successive layer of the substantially complexed acetaminophen and polyvinylpyrrolidone being adhered to the seed or to the preceding layer by the adhesive, the bead including at least 50% by weight of acetaminophen.
Claim 13
Dependent Claim
85 words
An acetaminophen product comprising a plurality of beads not compressed into a tablet, each bead being formed of a central, small, essentially spheroidal seed and successive layers formed from powdered acetaminophen substantially complexed with the polyvinylpyrrolidone in an adhesive comprising from about an 8 to about 12% solution of polyvinylpyrrolidone in alcohol, each successive layer of the substantially complexed acetaminophen and polyvinylpyrrolidone being adhered to the seed or to the preceding layer by the adhesive, the bead including at least 50% by weight of acetaminophen.
Claim 14
Dependent Claim
18 words
The acetaminophen product as recited in claims 11 or 19 wherein the seed is 60-80 mesh in size.
Claim 15
Dependent Claim
21 words
The acetaminophen product of claim 12, wherein the seed is formed of pharmacologically inert material formed into an essentially spheroidal particle.
Claim 16
Dependent Claim
22 words
The acetaminophen product of claim 13 , wherein the seed material is selected from the group including potassium chloride and microcrystalline cellulose.
Claim 17
Dependent Claim
13 words
The acetaminophen product of claim 11, wherein the seed is formed of acetaminophen.
Claim 18
Dependent Claim
16 words
The acetaminophen product of claim 15, wherein the seed of acetaminophen is 60-80 mesh in size.
Claim 19
Dependent Claim
20 words
The acetaminophen product as recited in claims 11 or wherein the bead is coated with a suitable time release material.
Claim 20
Dependent Claim
32 words
The acetaminophen product as recited in claim 17, wherein the time release material includes a material selected from the group including ethylcellulose "pseudolatex", an aqueous anionic polymer and an alcoholic anionic polymer.
Claim 21
Dependent Claim
19 words
The acetaminophen product as recited in claims 11 wherein the bead includes at least 90% by weight of acetaminophen.
Claim 22
Dependent Claim
19 words
The acetaminophen product as recited in claims 11, and including a plurality of said beads encapsulated in a capsule.
Claim 23
Dependent Claim
22 words
The acetaminophen product as recited in claim 20, wherein the capsule is selected from the group including zero and A sized capsules.
Claim 24
Dependent Claim
24 words
The acetaminophen product as recited in claim 21, wherein at least a portion of the beads are coated with a suitable time release material.
Claim 25
Dependent Claim
92 words
A drug product comprising a plurality of beads not compressed into a tablet, each bead being formed of a small, essentially spheroidal central seed of a drug material selected from the group consisting of aspirin, acetaminophen and mixtures thereof and successive layers of small particles of said drug material substantially complexed with the polyvinylpyrrolidone in an adhesive comprising about an 8 to about 12% solution of polyvinylpyrrolidone in alcohol, each successive layer of the substantially complexed drug material and polyvinylpyrrolidone being adhered to the seed or the preceding layer by the adhesive.
Claim 26
Dependent Claim
92 words
A drug product comprising a plurality of beads not compressed into a tablet, each bead being formed of a small, essentially spheroidal central seed of a drug material selected from the group consisting of aspirin, acetaminophen and mixtures thereof and successive layers of small particles of said drug material substantially complexed with the polyvinylpyrrolidone in an adhesive comprising about an 8 to about 12% solution of polyvinylpyrrolidone in alcohol, each successive layer of the substantially complexed drug material and polyvinylpyrrolidone being adhered to the seed or the preceding layer by the adhesive.
Claim 27
Dependent Claim
20 words
A drug product as recited in claim 23, wherein the bead includes at least 50% of weight of the drug.
Claim 28
Dependent Claim
20 words
A drug product as recited in claim 24, wherein the bead includes at least 90% by weight of the drug.
Claim 29
Dependent Claim
27 words
A drug product as recited in claim 23, and including a plurality of said beads, at least a portion of said beads including a time release coating.
Claim 30
Dependent Claim
14 words
The aspirin product of claim 1, wherein the seed is 60-80 mesh in size.
Claim 31
Dependent Claim
19 words
The aspirin product of claim 1, wherein the powdered aspirin has a mesh size of about 60 or more.
Claim 32
Dependent Claim
48 words
The aspirin product of claim 28, wherein the central seed and powdered aspirin has a mesh size of from about 60 to about 80, the seed is selected from the group including aspirin, potassium chloride and micro-crystalline cellulose, and including a gelatin capsule containing said plurality of beads.
Claim 33
Dependent Claim
21 words
The aspirin product of claim 29, wherein at least a portion of the beads are coated with a suitable time-release material.
Claim 34
Dependent Claim
19 words
The acetaminophen product of claim 11, wherein the powdered acetaminophen has a mesh size of about 60 or more.
Claim 35
Dependent Claim
48 words
The acetaminophen product of claim 31, wherein the central seed and powdered acetaminophen has a mesh size of from about 60 to about 80, the seed is selected from the group including acetaminophen, potassium chloride and micro-crystalline cellulose, and including a gelatin capsule containing said plurality of beads.
Claim 36
Dependent Claim
21 words
The acetaminophen product of claim 32, wherein at least a portion of the beads are coated with a suitable time-release material.
Claim 37
Dependent Claim
20 words
The drug product of claim 23, wherein the drug product particles have a mesh size of about 60 or more.
Claim 38
Dependent Claim
32 words
The drug product of claim 34, wherein the seeds and the granules of said drug material are about 60-80 mesh in size, and including a gelatin capsule carrying said plurality of beads.
Claim 39
Dependent Claim
21 words
The drug product of claim 35, wherein at least a portion of said beads are coated with a suitable time-release material.
Claim 40
Dependent Claim
18 words
The drug product of claim 23, wherein the essentially central spheroidal see is about 60-80 mesh in size.
References Cited (Backward Citations)
GB742007A
Cited
US2811483A
Cited
US2853420A
Cited
GB844772A
Cited
US2928770A
Cited
US3415758A
Cited
US3155590A
Cited
US3344029A
Cited
US3341416A
Cited
US3420931A
Cited
US3400185A
Cited
US3488418A
Cited
US3524910A
Cited
US3446891A
Cited
US3492397A
Cited
US3882228A
Cited
GB1326995A
Cited
US3835221A
Cited
US3906086A
Cited
US3917813A
Cited
US3851032A
Cited
US4083949A
Cited
US4268496A
Cited
GB1561301A
Cited
US4138475A
Cited
US4412986A
Cited
US4344934A
Cited
US4173626A
Cited
US4308251A
Cited
US4367217A
Cited
US4339428A
Cited
US4443497A
Cited
US4562061A
Cited
US4427648A
Cited
US4438091A
Cited
US4375468A
Cited
US4415547A
Cited
US4562024A
Cited
US4562069A
Cited
US4555399A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-09-18 | 1993-03-20 | 1993-09-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-09-18 | 1997-03-20 | 1997-09-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-09-18 | 2001-03-20 | 2001-09-19 | $7700.00 | Window Closed / Lapsed |