US4375468A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Constant order release aspirin composition and method of treating arthritis
Assignee: Verex Laboratories Inc
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Filing: 1982-04-08
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Granted: 1983-03-01
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Expires: 2002-04-08
Abstract
Abstract A constant order release aspirin tablet comprising aspirin, from 0.5 to 10 weight percent of a hydrogenated vegetable oil and from 0.5 to 7 weight percent of a saccharide selected from the group consisting of lactose, sucrose, dextrose fructose and maltose. The aspirin tablet is administered once or twice a day for the chronic treatment of arthritis, and has substantially lessened gastrointestinal side effects.
Inventors
- 👤 James M. Dunn
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 17:26
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/60; A61K9/00; A61K9/20; A61K9/2004; A61K9/2013; A61K9/2018
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
43 words
A constant order release aspirin tablet comprising aspirin, from 0.5 to 10 weight percent of a hydrogenated vegetable oil, from 0.5 to 7.0 weight percent of a saccharide selected from the group consisting of lactose, sucrose, dextrose, fructose and maltose, and a lubricant.
Claim 2
Dependent Claim
43 words
A constant order release aspirin tablet comprising aspirin, from 0.5 to 10 weight percent of a hydrogenated vegetable oil, from 0.5 to 7.0 weight percent of a saccharide selected from the group consisting of lactose, sucrose, dextrose, fructose and maltose, and a lubricant.
Claim 3
Dependent Claim
16 words
The aspirin tablet of claim 1 wherein said hydrogenated vegetable oil is hydrogenated cotton seed oil.
Claim 4
Dependent Claim
21 words
The aspirin tablet of claim 2 wherein said aspirin tablet includes from 1 to 6 weight percent of hydrogenated cottonseed oil.
Claim 5
Dependent Claim
27 words
The aspirin tablet of claim 1 wherein said tablet additionally comprises from 0.15 to 1.5 weight percent of a cellulose ether, cellulose ester or a combination thereof.
Claim 6
Dependent Claim
15 words
The aspirin tablet of claim 1, 2, 3 or 4 wherein said saccharide is lactose.
Claim 7
Dependent Claim
29 words
A constant order release aspirin tablet comprising aspirin, from 0.5 to 10 weight percent of hydrogenated cottonseed oil, from 0.5 to 7.0 weight percent of lactose and a lubricant.
Claim 8
Dependent Claim
29 words
A constant order release aspirin tablet comprising aspirin, from 0.5 to 10 weight percent of hydrogenated cottonseed oil, from 0.5 to 7.0 weight percent of lactose and a lubricant.
Claim 9
Dependent Claim
45 words
A constant order release aspirin tablet comprising aspirin, from 0.5 to 10 weight percent of hydrogenated cottonseed oil, from 0.5 to 7.0 weight percent of lactose, from 0.15 to 1.5 weight percent of a cellulose ether, cellulose ester or a combination thereof, and a lubricant.
Claim 10
Dependent Claim
45 words
A constant order release aspirin tablet comprising aspirin, from 0.5 to 10 weight percent of hydrogenated cottonseed oil, from 0.5 to 7.0 weight percent of lactose, from 0.15 to 1.5 weight percent of a cellulose ether, cellulose ester or a combination thereof, and a lubricant.
Claim 11
Independent Claim
95 words
A method of producing a control release aspirin tablet comprising the steps of dissolving from 0.5 to 10 weight percent of a hydrogenated vegetable oil in a suitable solvent, admixing said solution with a dry-blended mixture of from 85 to 98 weight percent of aspirin and from 0.5 to 7.0 weight percent of a saccharide selected from the group consisting of lactose, sucrose, dextrose, fructose and maltose to form a wet granulation, drying said wet granulation, sizing said granules, blending said sized granules with a lubricant and thereafter compressing said dried, sized granules into tablets.
Claim 12
Independent Claim
95 words
A method of producing a control release aspirin tablet comprising the steps of dissolving from 0.5 to 10 weight percent of a hydrogenated vegetable oil in a suitable solvent, admixing said solution with a dry-blended mixture of from 85 to 98 weight percent of aspirin and from 0.5 to 7.0 weight percent of a saccharide selected from the group consisting of lactose, sucrose, dextrose, fructose and maltose to form a wet granulation, drying said wet granulation, sizing said granules, blending said sized granules with a lubricant and thereafter compressing said dried, sized granules into tablets.
Claim 13
Dependent Claim
27 words
The method of claim 8 wherein from 0.15 to 1.5 weight percent of a cellulose ether, cellulose ester or a combination thereof is added to said solvent.
Claim 14
Dependent Claim
16 words
The method of claim 8 or 9 wherein said hydrogenated vegetable oil is hydrogenated cottonseed oil.
Claim 15
Dependent Claim
20 words
The method of claim 8, 9 or 10 wherein said solvent is a mixture of methylene chloride and denatured alcohol.
Claim 16
Dependent Claim
13 words
The method of claim 11 wherein said solvent mixture is a 1:1 mixture.
Claim 17
Dependent Claim
13 words
The method of claim 8, 9 or 10 wherein said saccharide is lactose.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-02-28 | 1986-08-30 | 1987-03-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-02-28 | 1990-08-30 | 1991-03-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-02-28 | 1994-08-30 | 1995-03-01 | $7700.00 | Window Closed / Lapsed |