US3882228A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Analgesic formulations
Assignee: Aspro Nicholas Ltd
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Filing: 1970-11-23
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Granted: 1975-05-06
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Expires: 1990-11-23
Abstract
Abstract Free-flowing readily wettable aspirin particles comprise a core of aspirin substantially encompassed by a layer comprising a water-soluble pharmaceutically acceptable coating material having a melting point of at least 105*C, said coating material including at least one coating agent selected from low molecular weight amino acids, sugars, sugar alcohols and mixtures thereof, and a process for preparation of such particles comprises the steps of preparing a suspension of aspirin in an aqueous solution containing the coating material, and spray-drying said suspension, the ingredients in the suspension being made present in such relative amounts that the spray-drying step results in the formation of the particles having the characteristics set forth.
Inventors
- 👤 Graham Arthur Boncey
- 👤 Maurice John Hedge
- 👤 James Rae Henderson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 11:52
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0002; A61K9/0007; A61K31/00; A61K31/60; A61K9/48; A61K9/50
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
106 words
FREE FLOWING READILY WETABLE COATED ASPIRIN PARTICLES, OF WHICH AT LEAST 95 PERCENT BY WEIGHT ARE NOT MORE THAN 150 MICRONS, COMPRISING: ONE PART OF ASPIRIN TO ONE TO ONE NINTH PART OF A COATING AGENT COMPRISING AT LEAST ONE INGREDIENT SELECTED FROM GLYCINE, METHIONINE, SUCROSE, LACTOSE, ARABINO GALACTAN SUGAR PRODUCTS, MANNITOL, INOSITOL AND SORBITOL; SAID COATING AGENT ALSO COMPRISING UP TO FIVE PERCENT BY WEIGHT OF A WETTING AGENT; AND UP TO TEN PERCENT BY WEIGHT OF A FILM FORMING AGENT SELECTED FROM HYDROXYL ETHYL CELLULOSE, HYDROXY PROPYL METHYL CELLULOSE, SODIUM CARBOXY METHYL CELLULOSE, STARCHES, DEXTRIN, DEXTRAN, GUM ACACIA, GUM TRAGICANTH AND POLY VINYL PYRROLIDONE.
Claim 2
Dependent Claim
106 words
FREE FLOWING READILY WETABLE COATED ASPIRIN PARTICLES, OF WHICH AT LEAST 95 PERCENT BY WEIGHT ARE NOT MORE THAN 150 MICRONS, COMPRISING: ONE PART OF ASPIRIN TO ONE TO ONE NINTH PART OF A COATING AGENT COMPRISING AT LEAST ONE INGREDIENT SELECTED FROM GLYCINE, METHIONINE, SUCROSE, LACTOSE, ARABINO GALACTAN SUGAR PRODUCTS, MANNITOL, INOSITOL AND SORBITOL; SAID COATING AGENT ALSO COMPRISING UP TO FIVE PERCENT BY WEIGHT OF A WETTING AGENT; AND UP TO TEN PERCENT BY WEIGHT OF A FILM FORMING AGENT SELECTED FROM HYDROXYL ETHYL CELLULOSE, HYDROXY PROPYL METHYL CELLULOSE, SODIUM CARBOXY METHYL CELLULOSE, STARCHES, DEXTRIN, DEXTRAN, GUM ACACIA, GUM TRAGICANTH AND POLY VINYL PYRROLIDONE.
Claim 3
Dependent Claim
19 words
Pharmaceutical compositions comprising the free-flowing readily wettable aspirin particles claimed in claim 1, and a pharmaceutically acceptable carrier therefor.
Claim 4
Dependent Claim
16 words
Free-flowing readily wettable aspirin particles, as claimed in claim 1, wherein the coating material includes mannitol.
Claim 5
Dependent Claim
16 words
Free-flowing readily wettable aspirin particles, as claimed in claim 1, wherein the coating material includes glycine.
Claim 6
Dependent Claim
61 words
Free-flowing readily wettable aspirin particles, as claimed in claim 1, exhibiting the following Physical properties: i. the melting point of the coating material being above 150*C ii. the ratio by weight of aspirin to coating material being from about 7:1 to about 1:1 iii. at least 95 percent by weight of the particles being not greater in size than 105 microns.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-05-05 | 1978-11-04 | 1979-05-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-05-05 | 1982-11-04 | 1983-05-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-05-05 | 1986-11-04 | 1987-05-06 | $7700.00 | Window Closed / Lapsed |