US4138475A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Sustained release pharmaceutical composition
Assignee: Syngenta Ltd
•
Filing: 1977-09-14
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Granted: 1979-02-06
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Expires: 1997-09-14
Abstract
Abstract Sustained release pharmaceutical composition consisting of a hard gelatine capsule containing film coated spheroids, the spheroids comprising propranolol, or a pharmaceutically-acceptable salt thereof, in admixture with non-water-swellable microcrystalline cellulose, and the said spheroids having a film coat comprising ethylcellulose optionally together with hydroxypropyl methylcellulose and/or a plasticizer.
Inventors
- 👤 James McAinsh
- 👤 Raymond C. Rowe
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:44
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13; A61K31/135; A61K9/00; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5036; A61K9/5042; A61K9/5047; A61P; A61P25/00; A61P25/02
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
56 words
A sustained release pharmaceutical composition consisting of a hard gelatine capsule containing film coated spheroids, the said spheroids comprising, prior to coating, 40 to 65% by weight of propranolol, or a pharmaceutically-acceptable acid-addition salt thereof, in admixture with non-water-swellable microcrystalline cellulose, and the said spheroids having a film coat comprising ethylcellulose or ethycellulose and hydroxpropyl methylcellulose.
Claim 2
Dependent Claim
56 words
A sustained release pharmaceutical composition consisting of a hard gelatine capsule containing film coated spheroids, the said spheroids comprising, prior to coating, 40 to 65% by weight of propranolol, or a pharmaceutically-acceptable acid-addition salt thereof, in admixture with non-water-swellable microcrystalline cellulose, and the said spheroids having a film coat comprising ethylcellulose or ethycellulose and hydroxpropyl methylcellulose.
Claim 3
Dependent Claim
31 words
The composition claimed in claim 1 in which the uncoated spheroids contain 50 to 60% by weight of propranolol hydrochloride and 50 to 40% by weight of non-water-swellable microcrystalline cellulose, respectively.
Claim 4
Dependent Claim
21 words
The composition claimed in claim 1 in which the film coat comprises 5 to 15% by weight of the coated spheroids.
Claim 5
Dependent Claim
19 words
The composition claimed in claim 1 in which the ethylcellulose has a viscosity of 50 cps at 20° C.
Claim 6
Dependent Claim
20 words
The composition claimed in claim 1 in which the hydroxypropyl methylcellulose has a viscosity of 6 cps at 20° C.
Claim 7
Dependent Claim
28 words
The composition claimed in claim 1 in which the film coat comprises 80 to 100% by weight of ethylcellulose and 20 to 0% by weight of hydroxypropyl methylcellulose.
Claim 8
Dependent Claim
20 words
The composition claimed in claim 1 in which the film coat contains up to 20% by weight of a plasticizer.
Claim 9
Dependent Claim
20 words
The composition claimed in claim 1 which contains 100 to 200 mg. of propranolol or a pharmaceutically-acceptable acid-addition salt thereof.
Claim 10
Dependent Claim
92 words
The composition claimed in claim 1 in which, prior to coating, the spheroids contain 60% by weight of propranolol hydrochloride in admixture with 40% by weight of non-water-swellable microcrystalline cellulose, and the spheroids have a film coat consisting of 90% by weight of ethylcellulose having a viscosity of 50 cps at 20° C. and 10% by weight of hydroxypropyl methylcellulose having a viscosity of 6 cps at 20° C., the film coat comprising 9 to 10% by weight of the coated spheroids, and the said composition containing 160 mg. of propranolol hydrochloride.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-02-05 | 1982-08-07 | 1983-02-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-02-05 | 1986-08-07 | 1987-02-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-02-05 | 1990-08-07 | 1991-02-06 | $7700.00 | Window Closed / Lapsed |