US4562069A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Two-phase formulation
Assignee: Bayer AG
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Filing: 1984-05-02
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Granted: 1985-12-31
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Expires: 2004-05-02
Abstract
Abstract In the treatment of cardiovascular and coronary disorders by administering to a patent suffering therefrom a solid preparation comprising nifedipine, the improvement which comprises administering such nifedipine in the form of a solid two-phase medicament formulation comprising a nifedipine coprecipitate, in which the nifedipine is present in a non-crystalline form, and crystalline nifedipine, whereby the nifedipine rapidly enters the blood stream in a relatively high concentration which is maintained for a relatively long time.
Inventors
- 👤 Ahmed Hegasy
- 👤 Roland Rupp
- 👤 Klaus-Dieter Ramsch
- 👤 Helmut Luchtenberg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 20:04
CPC Classifications
C; C07; C07D; C07D211/00; C07D211/04; C07D211/80; C07D211/84; C07D211/90; A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K9/00; A61K9/14; A61K9/141; A61K9/146
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
22 words
A solid two-phase medicament formulation comprising a nifedipine coprecipitate, in which the nifedipine is present in a non-crystalline form, and crystalline nifedipine.
Claim 2
Dependent Claim
22 words
A solid two-phase medicament formulation comprising a nifedipine coprecipitate, in which the nifedipine is present in a non-crystalline form, and crystalline nifedipine.
Claim 3
Dependent Claim
50 words
A two-phase medicament formulation according to claim 1, comprising a nifedipine coprecipitate, in which about 1 part by weight of nifedipine is present in a dissolved, non-crystalline form in about 1 to 10 parts by weight of coprecipitate former, and about 1 to 5 parts by weight of crystalline nifedipine.
Claim 4
Dependent Claim
44 words
A two-phase medicament formulation according to claim 1, in the form of tablets, coated tablets or hard gelatin capsules containing a nifedipine coprecipitate which comprises of 1 part by weight of nifedipine and about 1 to 10 parts by weight of a coprecipitate former.
Claim 5
Dependent Claim
24 words
A two-phase medicament formulation according to claim 3, wherein the nifedipine coprecipitate contains about 2 to 6 parts by weight of the coprecipitate former.
Claim 6
Dependent Claim
23 words
A two-phase medicament formulation according to claim 1, where the coprecipitate former is selected from the group comprising polyvinylpyrrollidone, methylcellulose, hydroxypropylcellulose and hydroxypropylmethylcellulose.
Claim 7
Dependent Claim
23 words
A two-phase medicament formulation according to claim 1, where the crystalline nifedipine has a mean particle diameter of about 10 to 1 μm.
Claim 8
Dependent Claim
25 words
A two-phase medicament formulation according to claim 6, wherein the nifedipine crystals have a specific surface area of about 1.0 to 4.0 m 2 /g.
Claim 9
Dependent Claim
14 words
A two-phase medicament formulation according to claim 2, wherein the coprecipitate former comprises polyvinylpyrrolidone.
Claim 10
Dependent Claim
58 words
In the treatment of cardiovascular and coronary disorders by administering to a patient suffering therefrom a solid preparation comprising nifedipine, the improvement which comprises administering such nifedipine in the form of a formulation according to claim 1, whereby the nifedipine rapidly enters the blod stream in a relatively high concentration which is maintained for a relatively long time.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-12-30 | 1989-07-01 | 1989-12-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-12-30 | 1993-07-01 | 1993-12-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-12-30 | 1997-07-01 | 1997-12-31 | $7700.00 | Window Closed / Lapsed |