Abstract 1. A METHOD OF PREPARING A COMPOSITION CONTAINING PARACETAMOL IN FINE CRYSTALLINE FORM WHICH IS SUITABLE FOR DIRECT TABLET COMPRESSION, WHICH METHOD COMPRISES PROVIIDING A HOT AQUEOUS SOLUTION CONTAINING PARACETAMOL, AND FROM 1% TO 15%, BY WEIGHT ON THE WEIGHT OF THE PARACETAMOL, OF A POLYMER SELECTED FROM HOMOPOLYMERS AND COPOLYMERS OF VINYL ACETATE AND VINYL PYRROLIDONE DISSOLVED IN SAID HOT AQUEOUS SOLUTION, BEING HEATED TO AT LEAST 95*C. WHILE AVOIDING EXCESSIVE HEATIING TENDING TO CAUSE THE POLYNMER TO CROSS-LINK OR TO BREAK DOWN, COOLING THIS SOLUTIION WITH GENTLE STIRRING, RECOVERING A SOLID FINE CRYSTALLIINE PARRACETAMOL POLYMER COMPLEX COMPOSITION THEREFROM, SAID COMPOSITION WHEN SUBJECTED TO RAMAN SPECTROSCOPY, ELECTRON MICROSCOPY AND X-RAY CRYSTALLOGRAPHIC ANALYSES INDICATING THAT THE POLYMER IS DISTRIBUTED ITHROUGHOUT EACH CRYSTAL ASSOCIATED AS A COMPLEX, ADMIIXING CONVENTIIONAL TABLETTING EXCIIPIENTS THEREWITH, AND FORMONG TABLETS BY DIRECT TABLET COMPRESSION OF THE MIXTURE.
Inventors
👤 R Andrews
👤 C Barlow
👤 J Livingstone
Bibliographic Details
Application Number—
JurisdictionUS
Data Sourcegoogle_patents
Last Synchronized2026-10-24 04:45
CPC Classifications
A; A61; A61J; A61J3/00; A61J3/10
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
140 words
A METHOD OF PREPARING A COMPOSITION CONTAINING PARACETAMOL IN FINE CRYSTALLINE FORM WHICH IS SUITABLE FOR DIRECT TABLET COMPRESSION, WHICH METHOD COMPRISES PROVIIDING A HOT AQUEOUS SOLUTION CONTAINING PARACETAMOL, AND FROM 1% TO 15%, BY WEIGHT ON THE WEIGHT OF THE PARACETAMOL, OF A POLYMER SELECTED FROM HOMOPOLYMERS AND COPOLYMERS OF VINYL ACETATE AND VINYL PYRROLIDONE DISSOLVED IN SAID HOT AQUEOUS SOLUTION, BEING HEATED TO AT LEAST 95*C. WHILE AVOIDING EXCESSIVE HEATIING TENDING TO CAUSE THE POLYNMER TO CROSS-LINK OR TO BREAK DOWN, COOLING THIS SOLUTIION WITH GENTLE STIRRING, RECOVERING A SOLID FINE CRYSTALLIINE PARRACETAMOL POLYMER COMPLEX COMPOSITION THEREFROM, SAID COMPOSITION WHEN SUBJECTED TO RAMAN SPECTROSCOPY, ELECTRON MICROSCOPY AND X-RAY CRYSTALLOGRAPHIC ANALYSES INDICATING THAT THE POLYMER IS DISTRIBUTED ITHROUGHOUT EACH CRYSTAL ASSOCIATED AS A COMPLEX, ADMIIXING CONVENTIIONAL TABLETTING EXCIIPIENTS THEREWITH, AND FORMONG TABLETS BY DIRECT TABLET COMPRESSION OF THE MIXTURE.
Claim 2
Independent Claim
140 words
A METHOD OF PREPARING A COMPOSITION CONTAINING PARACETAMOL IN FINE CRYSTALLINE FORM WHICH IS SUITABLE FOR DIRECT TABLET COMPRESSION, WHICH METHOD COMPRISES PROVIIDING A HOT AQUEOUS SOLUTION CONTAINING PARACETAMOL, AND FROM 1% TO 15%, BY WEIGHT ON THE WEIGHT OF THE PARACETAMOL, OF A POLYMER SELECTED FROM HOMOPOLYMERS AND COPOLYMERS OF VINYL ACETATE AND VINYL PYRROLIDONE DISSOLVED IN SAID HOT AQUEOUS SOLUTION, BEING HEATED TO AT LEAST 95*C. WHILE AVOIDING EXCESSIVE HEATIING TENDING TO CAUSE THE POLYNMER TO CROSS-LINK OR TO BREAK DOWN, COOLING THIS SOLUTIION WITH GENTLE STIRRING, RECOVERING A SOLID FINE CRYSTALLIINE PARRACETAMOL POLYMER COMPLEX COMPOSITION THEREFROM, SAID COMPOSITION WHEN SUBJECTED TO RAMAN SPECTROSCOPY, ELECTRON MICROSCOPY AND X-RAY CRYSTALLOGRAPHIC ANALYSES INDICATING THAT THE POLYMER IS DISTRIBUTED ITHROUGHOUT EACH CRYSTAL ASSOCIATED AS A COMPLEX, ADMIIXING CONVENTIIONAL TABLETTING EXCIIPIENTS THEREWITH, AND FORMONG TABLETS BY DIRECT TABLET COMPRESSION OF THE MIXTURE.