Patent US4863735A successfully refreshed from Google Patents.
US4863735A
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US
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Biodegradable polymeric drug delivery system with adjuvant activity
Assignee: Massachusetts Institute of Technology
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Filing: 1986-10-02
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Granted: 1989-09-05
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Expires: 2006-10-02
Abstract
Abstract An antigen delivery system utilizing a biodegradable polymer with good mechanical properties in combination with a material stimulating the immune system. The material having adjuvant activity may be polymer degradation products or an adjuvant which is contained within or bound to the polymer. In one embodiment, the polymer is formed from tyrosine dipeptides. Poly(CTTH-iminocarbonate) is a preferred tyrosine dipeptide polymer for constructing implantable delivery systems for antigenic material. The polymer is not an adjuvant in itself but degrades into products which stimulate the immune system. The tyrosine dipeptide can also be used as a conventional adjuvant. The advantages of the system are that a polymer can be used to form a biodegradable integral structure which is useful as both an implantable source of an antigen or other biologically active compound and as a control means for the rate of release of the biologically active compound, wherein the result is sustained, relatively constant delivery of antigen with simultaneous stimulation of the immune response.
Inventors
- 👤 Joachim B. Kohn
- 👤 Robert S. Langer
- 👤 Steven M. Niemi
- 👤 James G. Fox
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:20
CPC Classifications
C; C08; C08G; C08G69/00; C08G69/02; C08G69/08; C08G69/10; A; A61; A61K; A61K39/00; A61K39/39; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/59; A61K2039/555; A61K2039/55511; A61K2039/55516; A61K2039/55555; A61K2039/55566
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
40 words
An implantable, polymeric device for delivery of biologically active compounds, said device comprising at least one biologically active compound and a biodegradable, tyrosine dipeptide polymer said polymer degrading to form a product having adjuvant activity for said biologically active compound.
Claim 2
Dependent Claim
40 words
An implantable, polymeric device for delivery of biologically active compounds, said device comprising at least one biologically active compound and a biodegradable, tyrosine dipeptide polymer said polymer degrading to form a product having adjuvant activity for said biologically active compound.
Claim 3
Dependent Claim
32 words
The device of claim 1 further comprising an additional material having adjuvant activity for said biologically active compound, said additional material being chemically bound to the tyrosine dipeptide polymer forming the device.
Claim 4
Dependent Claim
24 words
The device of claim 1 wherein the tyrosine dipeptide polymer having adjuvant activity is a degradation product of the biodegradable polymer forming the device.
Claim 5
Dependent Claim
20 words
The device of claim 1 wherein said tyrosine dipeptide polymer is selected from the group consisting of poly(CTTH-iminocarbonate) and poly(CTTE-iminocarbonate).
Claim 6
Dependent Claim
19 words
The device of claim 1 wherein said polymers are chemically structured to degrade over a specific period of time.
Claim 7
Dependent Claim
15 words
The device of claim 1 wherein said tyrosine dipeptide polymer encapsulates the biologically active compound.
Claim 8
Dependent Claim
17 words
The device of claim 1 wherein the biologically active compound is dispersed within the tyrosine dipeptide polymer.
Claim 9
Dependent Claim
27 words
The device of claim 1 wherein said biologically active compound is selected from the group consisting of antigens, immunomodulators, drugs, inorganic compounds, nucleic acids, lipids and saccharides.
Claim 10
Dependent Claim
41 words
The device of claim 1 wherein the tyrosine dipeptide polymer further encapsulates a material having adjuvant activity for said biologically active compound, said material being selected from the group consisting of complete Freund's adjuvant, muramyl acid, and tyrosine and tyrosine derivatives.
Claim 11
Dependent Claim
58 words
A biodegradable device for the controlled release of at least one biologically active compound, said device comprising a tyrosine dipeptide polymer and at least one biologically active compound, which device, when implanted into a host, controllably releases the biologically active compound while simultaneously degrading to form a compound having adjuvant activity for the controllably released, biologically active compound.
Claim 12
Dependent Claim
58 words
A biodegradable device for the controlled release of at least one biologically active compound, said device comprising a tyrosine dipeptide polymer and at least one biologically active compound, which device, when implanted into a host, controllably releases the biologically active compound while simultaneously degrading to form a compound having adjuvant activity for the controllably released, biologically active compound.
Claim 13
Dependent Claim
16 words
A biodegradable device as in claim 10 further containing therein an additional material having adjuvant activity.
Claim 14
Dependent Claim
26 words
A biodegradable device as in claim 11 wherein said additional material is selected from the group consisting of Freund's adjuvant, muramyl acid, tyrosine and tyrosine derivatives.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-09-04 | 1993-03-06 | 1993-09-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-09-04 | 1997-03-06 | 1997-09-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-09-04 | 2001-03-06 | 2001-09-05 | $7700.00 | Window Closed / Lapsed |