EP0018189A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Synthetic adjuvants for stimulating antigenic responses
Assignee: Sanofi Pasteur Ltd
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Filing: 1980-04-15
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Granted: —
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Expires: 2000-04-15
Abstract
Abstract An antigen composition such as tetanus toxoid or polyomyelitis vaccine having an improved efficacy over the plain antigen comprises at least one bacterial or viral antigenic species and at least one adjuvant in an amount effective to enhance the antigenic response of the antigenic species; the adjuvant is an ester of a long chain alcohol containing 10 to 22 carbon atoms and an amino acid, for example octadecyl tyrosine.
Inventors
- 👤 Peter Joseph Moloney
- 👤 George Wojcik
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 20:20
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/39; A61K2039/555; A61K2039/55511; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
53 words
An antigen composition comprising at least one bacterial or viral antigenic species and at least one adjuvant in an amount effective to enhance the antigenic response of the antigenic species, characterized in that the adjuvant is an ester of a long chain alcohol containing 10 to 22 carbon atoms and an amino acid.
Claim 2
Dependent Claim
53 words
An antigen composition comprising at least one bacterial or viral antigenic species and at least one adjuvant in an amount effective to enhance the antigenic response of the antigenic species, characterized in that the adjuvant is an ester of a long chain alcohol containing 10 to 22 carbon atoms and an amino acid.
Claim 3
Dependent Claim
17 words
The composition claimed in claim 1, characterized in that the amino acid is an 0 (-amino acid.
Claim 4
Dependent Claim
26 words
The composition claimed in claim 1 or 2, characterized in that the ester is octadecyl tyrosine, which may be in the form of its hydrochloride salt.
Claim 5
Dependent Claim
20 words
The composition claimed in any one of claims 1 to 3, characterized in that the antigenic species is tetanus toxoid.
Claim 6
Dependent Claim
20 words
The composition claimed in any one of claims 1 to 3, characterized in that the antigenic species is poliomyelitis vaccine,
Claim 7
Dependent Claim
39 words
The use of an ester of a long chain alcohol containing 12 to 22 carbon atoms in the alkyl group and an amino acid as an adjuvant to enhance the antigenic response of a bacterial or viral antigenic species.
Claim 8
Dependent Claim
39 words
The use of an ester of a long chain alcohol containing 12 to 22 carbon atoms in the alkyl group and an amino acid as an adjuvant to enhance the antigenic response of a bacterial or viral antigenic species.
Claim 9
Dependent Claim
37 words
The use of octadecyl tyrosine, which may be in the form of its hydrochloride salt, as an adjuvant to enhance the antigenic response of a bacterial or viral antigenic species, such as, tetanus toxoid or poliomyelitis vaccine.
Claim 10
Dependent Claim
37 words
The use of octadecyl tyrosine, which may be in the form of its hydrochloride salt, as an adjuvant to enhance the antigenic response of a bacterial or viral antigenic species, such as, tetanus toxoid or poliomyelitis vaccine.
Claim 11
Independent Claim
89 words
A method of administration of bacterial or viral antigenic species to a warm blooded animal by injecting the animal with a dose of a composition comprising the bacterial or viral antigenic species and at least one adjuvant in an amount effective to enhance the antigenic response of the antigenic species and subsequently injecting the animal with a dose of said bacterial or viral antigenic species alone, characterized in that the adjuvant is an ester of a long chain alcohol containing 10 to 22 carbon atoms and an amino acid.
Claim 12
Independent Claim
89 words
A method of administration of bacterial or viral antigenic species to a warm blooded animal by injecting the animal with a dose of a composition comprising the bacterial or viral antigenic species and at least one adjuvant in an amount effective to enhance the antigenic response of the antigenic species and subsequently injecting the animal with a dose of said bacterial or viral antigenic species alone, characterized in that the adjuvant is an ester of a long chain alcohol containing 10 to 22 carbon atoms and an amino acid.
Claim 13
Dependent Claim
18 words
The method of claim 8 characterized in that the adjuvant is octadecyl tyrosine or a hydrochloride salt thereof.
Claim 14
Dependent Claim
16 words
The method of claim 8 or 9 characterized in that the antigenic species is poliomyelitis vaccine.
References Cited (Backward Citations)
No citation records indexed.
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