US4258029A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Synthetic adjuvants for stimulation of antigenic responses
Assignee: Sanofi Pasteur Ltd
•
Filing: 1979-04-23
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Granted: 1981-03-24
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Expires: 1999-04-23
Abstract
Abstract Long chain alcohol esters of amino acids are used as adjuvants in vaccines to provide an improved antigenic capability when compared with conventional adjuvants.
Inventors
- 👤 Peter J. Moloney
- 👤 George Wojcik
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:25
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/39; A61K39/02; A61K39/08; A61K39/12; A61K39/125; A61K39/13; A61K2039/555; A61K2039/55511; C; C12; C12N; C12N2770/00; C12N2770/00011; C12N2770/32011; C12N2770/32611; C12N2770/32634; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
57 words
In a composition comprising at least one bacterial or viral antigenic species and at least one adjuvant in an amount effective to enhance the antigenic response of said antigenic species, the improvement wherein said adjuvant is an ester of a long chain alcohol containing 12 to 22 carbon atoms in the alkyl group and an amino acid.
Claim 2
Dependent Claim
57 words
In a composition comprising at least one bacterial or viral antigenic species and at least one adjuvant in an amount effective to enhance the antigenic response of said antigenic species, the improvement wherein said adjuvant is an ester of a long chain alcohol containing 12 to 22 carbon atoms in the alkyl group and an amino acid.
Claim 3
Dependent Claim
13 words
The composition of claim 1 wherein said amino acid is an α-amino acid.
Claim 4
Dependent Claim
36 words
In a composition comprising at least one bacterial or viral antigenic species and an adjuvant in an amount effective to enhance the antigenic response of said antigenic species, the improvement wherein said adjuvant is octadecyl tyrosine.
Claim 5
Dependent Claim
36 words
In a composition comprising at least one bacterial or viral antigenic species and an adjuvant in an amount effective to enhance the antigenic response of said antigenic species, the improvement wherein said adjuvant is octadecyl tyrosine.
Claim 6
Dependent Claim
15 words
The composition of claim 1, 2 or 3 wherein said antigenic species is tetanus toxoid.
Claim 7
Dependent Claim
15 words
The composition of claim 1, 2 or 3 wherein said antigenic species is poliomyelitis vaccine.
Claim 8
Independent Claim
98 words
The method of administration of antigenic species to a warm blooded animal, which comprises: (a) injecting the animal with a dose of a composition comprising at least one bacterial or viral antigenic species and at least one ester of a long chain alcohol containing 12 to 22 carbon atoms in the alkyl group and an amino acid as adjuvant in an amount at least effective to provide an enhanced antigenic activity in said animal following completion of said administration; and subsequently (b) injecting the animal with a dose of said at least one bacterial or viral antigenic species.
Claim 9
Independent Claim
98 words
The method of administration of antigenic species to a warm blooded animal, which comprises: (a) injecting the animal with a dose of a composition comprising at least one bacterial or viral antigenic species and at least one ester of a long chain alcohol containing 12 to 22 carbon atoms in the alkyl group and an amino acid as adjuvant in an amount at least effective to provide an enhanced antigenic activity in said animal following completion of said administration; and subsequently (b) injecting the animal with a dose of said at least one bacterial or viral antigenic species.
Claim 10
Dependent Claim
18 words
The method of claim 6 wherein said antigenic species is poliomyelitis vaccine and said ester is octadecyl tyrosine.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-03-23 | 1984-09-22 | 1985-03-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-03-23 | 1988-09-22 | 1989-03-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-03-23 | 1992-09-22 | 1993-03-24 | $7700.00 | Window Closed / Lapsed |