Patent US482911A successfully refreshed from Google Patents.
Patent US4851392A successfully refreshed from Google Patents.
US4851392A
Expired / Lapsed
US
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Ingestible aggregate and delivery system prepared therefrom
Assignee: Warner Lambert Co LLC
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Filing: 1988-02-29
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Granted: 1989-07-25
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Expires: 2008-02-29
Abstract
Abstract The present invention relates to an ingestible aggregate comprising a pre-swelled substantially anhydrous hydrocolloid and a substrate. More particularly this invention relates to an aggregate having as a substrate a dietary fiber and/or drug wherein the composition can be administered in a therapeutically effective amount. Hydrocolloids useful include natural and modified gums, celluloses, modified celluloses, pectins, mucillages, modified starches, noncellulose polysaccharides, algal polysaccharides and mixtures thereof. The aggregate should be in the size range of about 4 to about 70 U.S. mesh. The unpleasant taste and mouthfeel of the fiber and/or drug is effectively masked and substantial hydration is delayed until the composition reaches the stomach. The compositions are substantially more platable, devoid of graininess, bitterness or fibrous texture. The pleasant taste of the composition encourages patient compliance with their fiber or drug therapy.
Inventors
- 👤 James J. Shaw
- 👤 Shri C. Sharma
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 08:08
CPC Classifications
A; A23; A23G; A23G3/00; A23G3/34; A23G3/36; A23G3/364; A23G3/368; A23L; A23L33/00; A23L33/20; A23L33/21; A61; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/0056; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1652; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5036; A61K9/5042; A61K9/5047; A61K9/5073
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
132 words
A method of preparing an ingestible aggregate comprising: (a) preparing an aqueous composition of a hydrocolloid selected from the group consisting of natural and modified gums, celluloses and modified celluloses, pectin, mucillages, modified starches, noncellulosic polysaccharides and mixtures thereof; (b) fluidizing substantially anhydrous solid substrate particles selected from the group consisting of dietary fibers, drugs and mixtures thereof in an air stream, the substrate particles not being the identical material as the hydrocolloid; (c) contacting the substrate particles with the aqueous hydrocolloid composition at a pressure of about 1 to about 5 bar to form the aggregates of the substrate and hydrocolloid and (d) drying and collecting the aggregates, the aggregates having a particle size of about 4 to about 80 mesh, U.S. Std. Sieve and a density of about 0.25 g/cc.
Claim 2
Independent Claim
132 words
A method of preparing an ingestible aggregate comprising: (a) preparing an aqueous composition of a hydrocolloid selected from the group consisting of natural and modified gums, celluloses and modified celluloses, pectin, mucillages, modified starches, noncellulosic polysaccharides and mixtures thereof; (b) fluidizing substantially anhydrous solid substrate particles selected from the group consisting of dietary fibers, drugs and mixtures thereof in an air stream, the substrate particles not being the identical material as the hydrocolloid; (c) contacting the substrate particles with the aqueous hydrocolloid composition at a pressure of about 1 to about 5 bar to form the aggregates of the substrate and hydrocolloid and (d) drying and collecting the aggregates, the aggregates having a particle size of about 4 to about 80 mesh, U.S. Std. Sieve and a density of about 0.25 g/cc.
Claim 3
Dependent Claim
14 words
The process of claim 1 wherein the hydrocolloid is sprayed onto the substrate particles.
Claim 4
Independent Claim
135 words
A method of preparing a pharmaceutical preparation comprising the steps of: (a) preparing an aqueous composition of a hydrocolloid selected from the group consisting of natural and modified gums, celluloses and modified celluloses, pectin, mucillages, modified starches, noncellulosic polysaccharides and mixtures thereof; (b) fluidizing substantially anhydrous solid substrate particles selected from the group consisting of dietary fibers, drugs and mixtures thereof in an air stream, the substrate particles not being the identical material as the hydrocolloid; (c) contacting the substrate particles with the aqueous hydrocolloid composition at a pressure of about 1 to about 5 bar to form the aggregates of the substrate and hydrocolloid and (d) drying and collecting the aggregates, the aggregates having a particle size of about 4 to about 80 mesh, U.S. Std. Sieve and a density of about 0.25 g/cc.
Claim 5
Independent Claim
135 words
A method of preparing a pharmaceutical preparation comprising the steps of: (a) preparing an aqueous composition of a hydrocolloid selected from the group consisting of natural and modified gums, celluloses and modified celluloses, pectin, mucillages, modified starches, noncellulosic polysaccharides and mixtures thereof; (b) fluidizing substantially anhydrous solid substrate particles selected from the group consisting of dietary fibers, drugs and mixtures thereof in an air stream, the substrate particles not being the identical material as the hydrocolloid; (c) contacting the substrate particles with the aqueous hydrocolloid composition at a pressure of about 1 to about 5 bar to form the aggregates of the substrate and hydrocolloid and (d) drying and collecting the aggregates, the aggregates having a particle size of about 4 to about 80 mesh, U.S. Std. Sieve and a density of about 0.25 g/cc.
Claim 6
Dependent Claim
11 words
The method of claim 3 wherein the substrate is potassium chloride.
Claim 7
Dependent Claim
10 words
The method of claim 3 wherein the substrate is cholestyramine.
Claim 8
Dependent Claim
10 words
The method of claim 3 wherein the substrate is N-acetylprocainamide.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-07-24 | 1993-01-23 | 1993-07-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-07-24 | 1997-01-23 | 1997-07-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-07-24 | 2001-01-23 | 2001-07-25 | $7700.00 | Window Closed / Lapsed |