US3907983A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical preparations
Assignee: F Hoffmann La Roche AG
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Filing: 1974-01-30
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Granted: 1975-09-23
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Expires: 1994-01-30
Abstract
Abstract Powders, the individual particles thereof coated with from about 0.5% to 10% by weight of a material which makes the powder nydrophilic, and which are free flowing as well as amenable to tabletting by direct compression are disclosed as well as a method for making such powders and tablets.
Inventors
- 👤 Pyare Lal Seth
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:17
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/167; A61K9/1676; A61K9/20; A61K9/2095; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5036; A61K9/5042; A61K9/5047
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
57 words
A FREE-FLOWING WATER WETTABLE POWDER WHICH IS DIRECTLY COMPRESSIBLE WITHOUT PRIOR GRANULATION INTO RAPIDLY ABSORBED TABLETS AND WHICH IS COMPOSED OF INDIVIDUAL RAPIDLY DISINTEGRATING PARTICLES OF A PHARMACEUTICALLY ACTIVE SUBSTANCE SPRAYCOATED FROM AQUEOUS SOLUTIONS WITH FROM ABOUT 0.5% TO ABOUT 10% BY WEIGHT OF A HYDROPHILISING MATERIAL SELECTED FROM THE GROUP CONSISTING OF METHYLCELLULOSE, HYDROXYETHYLMETHYLCELLULOSE AND HYDROXYPROPYLMETHYLCELLULOSE.
Claim 2
Dependent Claim
57 words
A FREE-FLOWING WATER WETTABLE POWDER WHICH IS DIRECTLY COMPRESSIBLE WITHOUT PRIOR GRANULATION INTO RAPIDLY ABSORBED TABLETS AND WHICH IS COMPOSED OF INDIVIDUAL RAPIDLY DISINTEGRATING PARTICLES OF A PHARMACEUTICALLY ACTIVE SUBSTANCE SPRAYCOATED FROM AQUEOUS SOLUTIONS WITH FROM ABOUT 0.5% TO ABOUT 10% BY WEIGHT OF A HYDROPHILISING MATERIAL SELECTED FROM THE GROUP CONSISTING OF METHYLCELLULOSE, HYDROXYETHYLMETHYLCELLULOSE AND HYDROXYPROPYLMETHYLCELLULOSE.
Claim 3
Dependent Claim
13 words
The powder of claim 1 wherein the hydrophilising material is hydroxypropyl methyl cellulose.
Claim 4
Dependent Claim
33 words
The powder of claim 1 wherein the active substance is coated with about 1% to about 5% by weight of a hydrophilising material selected from the group consisting of methylcellulose, hydroxyethylmethylcellulose and hydroxypropylmethylcellulose.
Claim 5
Dependent Claim
33 words
The powder of claim 1 wherein the active substance is coated with about 2% to about 3% by weight of a hydrophilising material selected from the group consisting of methylcellulose, hydroxyethylmethylcellulose and hydroxypropylmethylcellulose.
Claim 6
Dependent Claim
38 words
The powder of claim 1 wherein the individual particles thereof are composed of a mixture of pharmaceutically active substances, each of which is coated with a hydrophilising material selected from the group consisting of methylcellulose, hydroxyethylmethylcellulose and hydroxypropylmethylcellulose.
Claim 7
Dependent Claim
46 words
The powder of claim 1 wherein the individual particles thereof are composed of a mixture of a pharmaceutically active substance and pharmaceutically acceptable tabletting adjuvants and excipients, each of which is coated with a hydrophilising material selected from the group consisting of methylcellulose, hydroxyethylmethylcellulose and hydroxypropylmethylcellulose.
Claim 8
Dependent Claim
11 words
The powder of claim 3 wherein the hydrophilising material is hydroxypropylmethyl-cellulose.
Claim 9
Dependent Claim
11 words
The powder of claim 1 wherein the active substance is sulfamethoxazole.
Claim 10
Dependent Claim
16 words
The powder of claim 1 wherein the active substance is a mixture of sulfamethoxazole and trimethoprim.
Claim 11
Dependent Claim
10 words
The powder of claim 6 composed of 5-(6-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one and lactose.
References Cited (Backward Citations)
FR2106566A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-09-22 | 1979-03-24 | 1979-09-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-09-22 | 1983-03-24 | 1983-09-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-09-22 | 1987-03-24 | 1987-09-23 | $7700.00 | Window Closed / Lapsed |