US4758431A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
Assignee: Thomas Jefferson University
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Filing: 1982-09-30
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Granted: 1988-07-19
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Expires: 2002-09-30
Abstract
Abstract A novel system and method for treating ischemic neurologic tissue is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the cerebospinal pathway. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability of the nutrient emulsion. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the cerebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagonising the physiologic state of hypoxic-ischemic and other diseased neurologic tissue during treatment are provided.
Inventors
- 👤 Jewell L. Osterholm
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 01:46
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026; A61K31/00; A61K31/02; A61K9/0029; A61M; A61M3/00; A61M3/02; A61M3/0204; A61M3/0216; A61M3/022; A61M25/00; A61M25/01; A61M25/02; A61M2025/028; A61M2202/00; A61M2202/04; A61M2202/0468; A61M2202/0476; A61M2205/00; A61M2205/36; A61M2205/3653
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
86 words
An artificial central nervous system, cerebrospinal pathway treatment liquid for treating hypoxic-ischemic crebrospinal tissue, comprising: (a) a non-aqueous fluorocarbon oxygen transfer component for selectively combining with oxygen and for transferring oxygen to said tissues to be treated; (b) an aqueous nutrient component comprising at least essential electrolytes for said tissue; and (c) an emulsification component for permitting the emulsification of said nutrient means with said oxygen transfer means; said liquid, after oxygen saturation and prior to injection, having an osmolarity of between about 298 and 317.
Claim 2
Dependent Claim
86 words
An artificial central nervous system, cerebrospinal pathway treatment liquid for treating hypoxic-ischemic crebrospinal tissue, comprising: (a) a non-aqueous fluorocarbon oxygen transfer component for selectively combining with oxygen and for transferring oxygen to said tissues to be treated; (b) an aqueous nutrient component comprising at least essential electrolytes for said tissue; and (c) an emulsification component for permitting the emulsification of said nutrient means with said oxygen transfer means; said liquid, after oxygen saturation and prior to injection, having an osmolarity of between about 298 and 317.
Claim 3
Dependent Claim
75 words
An artificial central nervous system, cerebrospinal pathway treatment liquid for treating hypoxic/ischemic cerebrospinal tissue, comprising: (a) a non-aqueous fluorocarbon oxygen transfer component for selectively combining with oxygen and for transferring oxygen to said tissues to be treated; (b) an aqueous nutrient component comprising at least essential electrolytes for said tissue; and (c) an emulsification component for permitting the emulsification of said nutrient means with said oxygen transfer means; said nutrient component further comprising a pyruvate.
Claim 4
Dependent Claim
75 words
An artificial central nervous system, cerebrospinal pathway treatment liquid for treating hypoxic/ischemic cerebrospinal tissue, comprising: (a) a non-aqueous fluorocarbon oxygen transfer component for selectively combining with oxygen and for transferring oxygen to said tissues to be treated; (b) an aqueous nutrient component comprising at least essential electrolytes for said tissue; and (c) an emulsification component for permitting the emulsification of said nutrient means with said oxygen transfer means; said nutrient component further comprising a pyruvate.
Claim 5
Dependent Claim
23 words
The treatment liquid of claim 2 wherein said nutrient component further comprises a carbohydrate derivative which is a metabolic precursor of a pyruvate.
Claim 6
Dependent Claim
86 words
An artificial central nervous system, cerebrospinal pathway treatment liquid for treating hypoxic/ischemic cerebrospinal tissue, comprising: (a) a non-aqueous fluorocarbon oxygen transfer component for selectively combining with oxygen and for transferring oxygen to said tissues to be treated; (b) an aqueous nutrient component comprising at least essential electrolytes for said tissue; and (c) an emulsification component for permitting the emulsification of said nutrient means with said oxygen transfer means; said liquid having an osmolarity of between 318 and 325 and being thereby useful to treat cerebral edema.
Claim 7
Dependent Claim
86 words
An artificial central nervous system, cerebrospinal pathway treatment liquid for treating hypoxic/ischemic cerebrospinal tissue, comprising: (a) a non-aqueous fluorocarbon oxygen transfer component for selectively combining with oxygen and for transferring oxygen to said tissues to be treated; (b) an aqueous nutrient component comprising at least essential electrolytes for said tissue; and (c) an emulsification component for permitting the emulsification of said nutrient means with said oxygen transfer means; said liquid having an osmolarity of between 318 and 325 and being thereby useful to treat cerebral edema.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-07-19 | 1992-01-18 | 1992-07-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-07-19 | 1996-01-18 | 1996-07-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-07-19 | 2000-01-18 | 2000-07-19 | $7700.00 | Window Closed / Lapsed |