US4685900A — Therapeutic device

Claim 1

Independent Claim 122 words

A device for the treatment of a body fluid which comprises: (a) a means for withdrawing a body fluid from a patient; (b) a chamber means for receiving said body fluid having inlet and outlet means; (c) positioned within said chamber means a non-radiation grafted biospecific polymer comprising a biocompatible polymer support, a spacer covalently bonded to said biocompatible support, and a biological or biologicals covalently bonded to said spacer such that the biological or biologicals extend away from the surface of said polymer support, which biospecific polymer will chemically bond specific pathological effectors or specific groups of pathological effectors carried by said body fluid to remove said specific effectors therefrom; and (d) means for returning said body fluid to said patient.

Claim 2

Independent Claim 122 words

A device for the treatment of a body fluid which comprises: (a) a means for withdrawing a body fluid from a patient; (b) a chamber means for receiving said body fluid having inlet and outlet means; (c) positioned within said chamber means a non-radiation grafted biospecific polymer comprising a biocompatible polymer support, a spacer covalently bonded to said biocompatible support, and a biological or biologicals covalently bonded to said spacer such that the biological or biologicals extend away from the surface of said polymer support, which biospecific polymer will chemically bond specific pathological effectors or specific groups of pathological effectors carried by said body fluid to remove said specific effectors therefrom; and (d) means for returning said body fluid to said patient.

Claim 3

Dependent Claim 43 words

The device as recited in claim 1 wherein the biospecific polymer is of any structural configuration provided that sufficient surface area of the biospecific polymer is exposed to the body fluid to be treated to efficiently remove the desired amount of pathological effector.

Claim 4

Dependent Claim 15 words

The device as recited in claim 1 wherein the biocompatible polymer support is a hydrogel.

Claim 5

Dependent Claim 28 words

The device as recited in claim 1 wherein the biocompatible polymer support is selected from the group consisting of polymerized glycidyl acrylate, polymerized glycidyl methacrylate and mixtures thereof.

Claim 6

Dependent Claim 19 words

The device as recited in claim 1 wherein the biocompatible polymer support is the slightly cross-linked homopolymer hydroxyethyl methacrylate.

Claim 7

Dependent Claim 54 words

The device as recited in claim 1 wherein the biocompatible polymer support is selected from the group consisting of copolymerized N-vinyl pyrrolidone and glycidyl methacrylate said copolymer further containing a monomer selected from the group consisting of hydroxyalkylacrylates, hydroxyalkylmethacrylates, acrylamides, substituted acrylamides, vinyl glycidyl ethers, alkylglycidyl ethers, N-vinyl amides, vinyl acetate and mixtures thereof.

Claim 8

Dependent Claim 49 words

The device as recited in claim 1 wherein the biologicals are selected from the group consisting of acetylcholine receptor proteins, histocompatibility antigens, ribonucleic acids, basement membrane proteins, immunoglobulin classes and subclasses, myeloma protein receptors, complement components, myelin proteins, hormones and their receptor components and vitamins and their receptor components.

Claim 9

Dependent Claim 26 words

The device as recited in claim 1 wherein the biological is insulin used to remove anti-insulin antibody which is associated with the autoimmune disease insulin resistance.

Claim 10

Dependent Claim 27 words

The device as recited in claim 1 wherein the biological is purified gamma globulin to remove immune componnets which are associated with connective tissue and proliferative diseases.

Claim 11

Dependent Claim 16 words

The device as recited in claim 1 wherein the biocompatible polymer support is modified cellulose acetate.

Claim 12

Dependent Claim 23 words

The device as recited in claim 1 further characterized in that said biocompatible polymer support is fixed to a mechanically stable support member.

Claim 13

Dependent Claim 35 words

The device as recited in claim 11 wherein the mechanically stable support member is selected from the group consisting of polyester fiber, reticulated polymeric foams, microporous polypropylene, cottom cloth, polystyrene; polycarbonate, polyphenylene oxide, and polysiloxane.

Claim 14

Independent Claim 140 words

A device for the treatment of a body fluid which comprises: (a) means for withdrawing a body fluid from a patient; a patient; (b) a chamber means for receiving said body fluid having inlet and outlet means; (c) a plurality of fluid flow channels positioned within said chamber means so that said body fluid flows therebetween; (d) fixed on said fluid flow channels a non-radiation grafted biospecific polymer comprising a biocompatible polymer support, a spacer covalently bonded to said biocompatible polymer support and a biological or biologicals covalently bonded to said spacer such that said biological or biologicals extend away from the surface of said polymer support, which biospecific polymer will chemically bond at least one pathological effector carried by said body fluid to remove said pathological effector therefrom; and (e) means for returning said body fluid to said patient.

Claim 15

Independent Claim 140 words

A device for the treatment of a body fluid which comprises: (a) means for withdrawing a body fluid from a patient; a patient; (b) a chamber means for receiving said body fluid having inlet and outlet means; (c) a plurality of fluid flow channels positioned within said chamber means so that said body fluid flows therebetween; (d) fixed on said fluid flow channels a non-radiation grafted biospecific polymer comprising a biocompatible polymer support, a spacer covalently bonded to said biocompatible polymer support and a biological or biologicals covalently bonded to said spacer such that said biological or biologicals extend away from the surface of said polymer support, which biospecific polymer will chemically bond at least one pathological effector carried by said body fluid to remove said pathological effector therefrom; and (e) means for returning said body fluid to said patient.

Claim 16

Dependent Claim 23 words

The device as recited in claim 13 wherein the biocompatible polymer support comprises a terpolymer of glycidyl methacrylate, N-vinyl pyrrolidone and hydroxyethyl methacrylate.

Claim 17

Dependent Claim 128 words

A therapeutic method for the treatment of a body fluid which comprises: (a) withdrawing said body fluid from a patient; (b) admitting said body fluid into a chamber means; (c) contacting said body fluid within said chamber with a non-radiation grafted biospecific polymer comprising a biocompatible polymer support, a spacer covalently bonded to said biocompatible polymer support, and a biological or biologicals covalently bonded to said spacer such that the biological or biologicals extend away from the surface of said polymer support, which biospecific polymer will chemically bond at least one pathological effector carried by said body fluid to said biospecific polymer to remove said pathological effector from said body fluid; and (d) removing said body fluid from said chamber and returning said body fluid to said patient.

Claim 18

Dependent Claim 128 words

A therapeutic method for the treatment of a body fluid which comprises: (a) withdrawing said body fluid from a patient; (b) admitting said body fluid into a chamber means; (c) contacting said body fluid within said chamber with a non-radiation grafted biospecific polymer comprising a biocompatible polymer support, a spacer covalently bonded to said biocompatible polymer support, and a biological or biologicals covalently bonded to said spacer such that the biological or biologicals extend away from the surface of said polymer support, which biospecific polymer will chemically bond at least one pathological effector carried by said body fluid to said biospecific polymer to remove said pathological effector from said body fluid; and (d) removing said body fluid from said chamber and returning said body fluid to said patient.

Claim 19

Dependent Claim 17 words

The therapeutic method as recited in claim 15 wherein the withdrawing and returning steps are continuously performed.

Claim 20

Dependent Claim 30 words

The therapeutic method as recited in claim 15 wherein the body fluid to be treated is selected from the group consisting of blood, whole blood, blood plasma, and cerebrospinal fluid.

Claim 21

Dependent Claim 13 words

The method recited in claim 15 wherein said pathological effector is RF antigen.

Claim 22

Dependent Claim 13 words

The method recited in claim 15 wherein said pathological effector is RF antibody.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1990-08-10	1991-02-09	1991-08-11	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1994-08-10	1995-02-09	1995-08-11	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	1998-08-10	1999-02-09	1999-08-11	$7700.00	Window Closed / Lapsed

Therapeutic device

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