US4182750A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Bloodcompatible functional polymers
Assignee: Individual
•
Filing: 1977-04-21
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Granted: 1980-01-08
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Expires: 1997-04-21
Abstract
Abstract High molecular weight polymeric materials, which have incorporated within their structure modified protein(s), carbohydrate(s), nucleic acid(s), and/or lipid(s), capable of either transferring to blood, other biological fluid(s) or tissue(s), a desired substance(s), such as, for example, oxygen, selected antibody(ies), trace element(s), radioactively tagged structure(s), nutrient(s), enzyme(s), and/or other organic or inorganic chemical(s), drug(s) and pharmaceutical(s) of therapeutic value, or of extracting from blood, other biological fluid(s) or tissue(s), an undesired substance(s), such as, for example, carbon dioxide, toxic metabolic product(s), drug(s), and/or other organic or inorganic chemical(s), element(s), or deleterious substance(s). These polymeric materials are compatible with blood, other biological fluid(s) and tissue(s). They may be modified or combined so that the transfer of desired substance(s) to the blood, biological fluid(s) or tissue(s) can be carried out either simultaneous with, prior to, or subsequent to the extraction of undesirable substance(s) from blood, biological fluid(s) or tissue(s).
Inventors
- 👤 Thomas E. Sullivan
- 👤 Oscar L. Wright
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:29
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61K35/00; A61K35/12; A61K35/14; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/58; A61L; A61L27/00; A61L27/50; A61L27/54; A61M; A61M1/00; A61M1/36; A61M1/3679; A61M1/3687; A61L2300/00
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
83 words
Therapeutic materials made by chemically bonding to a base polymer formed by the vinyl polymerization of styrene, vinyl chloride, maleic anhydride, acrylic acid derivatives or nitrilo substituted ethylene, at least one substance selected from the group consisting of a modified protein, a carbohydrate, a nucleic acid, and a lipid, said substance being capable of transferring a desired ingredient to blood, biological fluid or tissue, upon contact therewith, these therapeutic materials being compatible with blood, biological fluid and tissue, and producing no undesirable effects.
Claim 2
Dependent Claim
83 words
Therapeutic materials made by chemically bonding to a base polymer formed by the vinyl polymerization of styrene, vinyl chloride, maleic anhydride, acrylic acid derivatives or nitrilo substituted ethylene, at least one substance selected from the group consisting of a modified protein, a carbohydrate, a nucleic acid, and a lipid, said substance being capable of transferring a desired ingredient to blood, biological fluid or tissue, upon contact therewith, these therapeutic materials being compatible with blood, biological fluid and tissue, and producing no undesirable effects.
Claim 3
Dependent Claim
20 words
A material in accordance with claim 1 which can oxygenate blood when blood is passed through and over these materials.
Claim 4
Dependent Claim
23 words
A material in accordance with claim 1 which can remove carbon dioxide from blood when blood is passed through and over these materials.
Claim 5
Dependent Claim
24 words
A material in accordance with claim 1 which oxygenates blood or biological fluid while simultaneously removing carbon dioxide from the same blood of fluid.
Claim 6
Dependent Claim
45 words
A material in accordance with claim 1 which adds to blood, biological fluid or tissue measured doses of either an antibody, a trace element, a radioactively tagged structure, a nutrient, an enzyme, or other organic or inorganic chemical drug or pharmaceutical of a therapeutic nature.
Claim 7
Dependent Claim
37 words
A material in accordance with claim 1 which extracts from blood, biological fluid or tissue, toxic metabolic products, toxic materials of other than metabolic origin, drugs, and other chemicals, elements, or substance deleterious to the host body.
Claim 8
Dependent Claim
30 words
A material in accordance with claim 1 designed to simultaneously transfer beneficial substances to blood, biological fluid or tissue and remove deleterious substances from the same blood, fluid, or tissue.
Claim 9
Dependent Claim
45 words
A material in accordance with claim 1 which is used in conjunction with dialysis membrances and other adsorbent materials to improve the efficiency of removing unwanted toxins or deleterious substances in the dialysis or sorbent treatment of patients with kidney malfunction, liver malfunction, or poisoning.
Claim 10
Dependent Claim
20 words
A material in accordance with claim 6 which is incorporated within the physical or chemical structure of dialysis membrance materials.
Claim 11
Dependent Claim
31 words
A method for the adjunctive treatment of body fluids or dialysate during peritoneal dialysis which comprises treating said body fluids or dialysate with a material as set forth in claim 1.
Claim 12
Dependent Claim
63 words
A method for enterally or parenterally removing toxins and unwanted substances from body areas or cavities or for administering to body areas or cavities an antibody, a trace element, a radioactively tagged structure, a nutrient, an enzyme, or other organic or inorganic chemical, drug, or pharmaceutical which comprises introducing into said body areas or cavities a material as set forth in claim 1.
Claim 13
Dependent Claim
63 words
A method for removing toxins and unwanted substances from blood, biological fluid or tissue or for administering to blood, biological fluid or tissue an antibody, a trace element, a radioactively tagged structure, a nutrient, an enzyme or other organic or inorganic chemical, drug, or a pharmaceutical which comprises introducing into said blood, fluid or tissue a material as set forth in claim 1.
Claim 14
Dependent Claim
43 words
A method for removing unwanted substances from or adding prescribed substances to fractions of blood or biological fluid obtained by plasmaphoresis or centrifugation methods which comprises adding to said fractions of blood or biological fluid a material as set forth in claim 1.
Claim 15
Dependent Claim
62 words
A method for removing toxins or unwanted substances from blood, biological fluid or tissue or to delay or improve the release of specific substances to blood, biological fluid or tissues which comprises encapsulating the material set forth in claim 1 with any of a number of clinically proven encapsulating substances and introducing said encapsulated material to said blood, biological fluid or tissue.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-01-07 | 1983-07-09 | 1984-01-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-01-07 | 1987-07-09 | 1988-01-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-01-07 | 1991-07-09 | 1992-01-08 | $7700.00 | Window Closed / Lapsed |