US4008047A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Blood compatible polymers for blood oxygenation devices
Assignee: North Star Research and Development Institute
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Filing: 1974-12-26
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Granted: 1977-02-15
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Expires: 1994-12-26
Abstract
Abstract Fluoroacylation of ethyl cellulose has been found to result in good gas permeability and blood compatibility for polymeric layers made from the resulting fluorinated esters. The fluoroacylated ethyl cellulose has good hydrolytic stability at blood pH and under sterilization conditions (e.g. 100° C). For use in blood oxygenation devices, implantable biomedical devices, blood sampling or analysis or purification devices, etc., it is preferred that the fluoroacylated ethyl cellulose be substantially free of residual OH and have a fluorine content above 10% by weight (e.g. at least about 12% by weight).
Inventors
- 👤 Robert J. Petersen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:26
CPC Classifications
C; C08; C08B; C08B13/00; A; A61; A61L; A61L33/00; A61L33/06; A61L33/08; B; B01; B01D; B01D71/00; B01D71/06; B01D71/08; B01D71/12; B01D71/22; Y; Y10; Y10S; Y10S128/00; Y10S128/03
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
146 words
In a blood oxygenation device comprising a means for bringing blood into contact with a gas-permeable support means and a means for conveying oxygenating gas to the other side of the gas-permeable support means, the improvement which comprises: a coating comprising fluoroacylated ethyl cellulose as a gas-permeable coating on said gas-permeable support means and for being in contact with the blood; wherein said fluorinated ethyl cellulose has a calculated chemically combined fluorine content of at least about 10% by weight and a degree of substitution ranging from about 1.0 to about 2.75, and wherein substantially all residual hydroxyls, including ring-substituted hydroxyls, have been converted to fluorinated ester groups of the formula --OCO(CF 2 ) m CF 3 , wherein m is a number ranging from 1 to 6; said fluoroacylated ethyl cellulose containing, at most, trace amounts of residual hydroxyl groups as determined by infrared analysis.
Claim 2
Dependent Claim
146 words
In a blood oxygenation device comprising a means for bringing blood into contact with a gas-permeable support means and a means for conveying oxygenating gas to the other side of the gas-permeable support means, the improvement which comprises: a coating comprising fluoroacylated ethyl cellulose as a gas-permeable coating on said gas-permeable support means and for being in contact with the blood; wherein said fluorinated ethyl cellulose has a calculated chemically combined fluorine content of at least about 10% by weight and a degree of substitution ranging from about 1.0 to about 2.75, and wherein substantially all residual hydroxyls, including ring-substituted hydroxyls, have been converted to fluorinated ester groups of the formula --OCO(CF 2 ) m CF 3 , wherein m is a number ranging from 1 to 6; said fluoroacylated ethyl cellulose containing, at most, trace amounts of residual hydroxyl groups as determined by infrared analysis.
Claim 3
Dependent Claim
23 words
Device according to claim 1, wherein said fluoroacylated ethyl cellulose has a chemically combined fluorine content of at least about 12% by weight.
Claim 4
Dependent Claim
64 words
Device according to claim 2, wherein said fluoroacylated ethyl cellulose averages about 0.5 to 1.6 perfluoroalkanoyl ester groups per disaccharide unit, said fluoroacylated ethyl cellulose having an ultimate tensile strength of at least 3000 pounds per square inch, a tensile modulus of at least 15,000 pounds per square inch, and more than twice the permeability to gaseous oxygen of the corresponding non-fluoroacylated ethyl cellulose.
Claim 5
Dependent Claim
139 words
A blood oxygenation device comprising: means for bringing blood of a living animal into contact with a major surface of a gas permeable membrane, and means for bringing oxygen gas into contact with the opposite major surface of said gas permeable membrane, said gas permeable membrane comprising an ethyl cellulose derivative which has a degree of substitution ranging from about 1.0 to about 2.75 and wherein substantially all residual hydroxyls, including substantially all ring-substituted hydroxyls, have been converted to fluorinated ester groups of the formula --OCO(CF 2 ) m CF 3 , wherein m is a number ranging from 1 to 6, said ethyl cellulose derivative containing, at most, trace amounts of residual hydroxyl groups as determined by infrared spectroscopic analysis; said ethyl cellulose derivative having a calculated chemically combined fluorine content of at least about 10% by weight.
Claim 6
Dependent Claim
139 words
A blood oxygenation device comprising: means for bringing blood of a living animal into contact with a major surface of a gas permeable membrane, and means for bringing oxygen gas into contact with the opposite major surface of said gas permeable membrane, said gas permeable membrane comprising an ethyl cellulose derivative which has a degree of substitution ranging from about 1.0 to about 2.75 and wherein substantially all residual hydroxyls, including substantially all ring-substituted hydroxyls, have been converted to fluorinated ester groups of the formula --OCO(CF 2 ) m CF 3 , wherein m is a number ranging from 1 to 6, said ethyl cellulose derivative containing, at most, trace amounts of residual hydroxyl groups as determined by infrared spectroscopic analysis; said ethyl cellulose derivative having a calculated chemically combined fluorine content of at least about 10% by weight.
Claim 7
Dependent Claim
52 words
A blood oxygenation device according to claim 4, wherein said ethyl cellulose derivative has about 4.4 to about 5.5 ethoxide groups and about 0.5 to about 1.0 perfluorobutyrate groups per disaccharide unit of said ethyl cellulose derivative, said ethyl cellulose derivative having a fluorine content of at least about 12% by weight.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-02-15 | 1980-08-16 | 1981-02-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-02-15 | 1984-08-16 | 1985-02-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-02-15 | 1988-08-16 | 1989-02-15 | $7700.00 | Window Closed / Lapsed |