US3963613A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Blood purification means
Assignee: Tanabe Pharma Corp
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Filing: 1974-12-26
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Granted: 1976-06-15
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Expires: 1994-12-26
Abstract
Abstract A blood purification means whereby blood of a patient to be treated is led around an external circuit connecting to the patient's blood stream and is brought into direct or indirect contact with a fumarate solution, and is further brought into direct or indirect contact with an enzymic preparation, which is suitably an aspartase preparation, which catalyzes a reaction of L-aspartic acid formation from fumaric acid and ammonia. The purification means may further include a preliminary stage or stages whereat an unrequired substance in a patient's blood is decomposed to a non toxic substance and ammonia subsequently convertable to aspartic acid, and may also include a low molecular sieve means preventing re-entry of aspartic acid produced into the patient's blood stream.
Inventors
- 👤 Ichiro Chibata
- 👤 Tetsuya Tosa
- 👤 Takao Mori
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:07
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/022; A61M; A61M1/00; A61M1/14; A61M1/16; A61M1/1694; A61M1/1696; A61M1/36; A61M1/3687
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
144 words
A blood purification means comprising a first cannula circuit for transport of blood having both ends which are adapted to be connected to the blood stream of a patient to be treated, a hemodialysis unit having a first dialysate provided in said first circuit, the first dialysate being effected with the blood of said first cannula circuit through a semi-permeable membrane, a second cannula circuit for transport of the first dialysate of said hemodialysis unit having both ends connected to said hemodialysis unit, a dialyzer having a second dialysate provided in said second cannula circuit, the second dialysate containing additions of fumarate and an aspartase preparation and being selectively effected with said first dialysate through a semipermeable membrane which permits diffusion therethrough of ammonia molecules, but not of aspartic acid molecules, and a pump for driving said first dialysate around said second cannula circuit.
Claim 2
Dependent Claim
144 words
A blood purification means comprising a first cannula circuit for transport of blood having both ends which are adapted to be connected to the blood stream of a patient to be treated, a hemodialysis unit having a first dialysate provided in said first circuit, the first dialysate being effected with the blood of said first cannula circuit through a semi-permeable membrane, a second cannula circuit for transport of the first dialysate of said hemodialysis unit having both ends connected to said hemodialysis unit, a dialyzer having a second dialysate provided in said second cannula circuit, the second dialysate containing additions of fumarate and an aspartase preparation and being selectively effected with said first dialysate through a semipermeable membrane which permits diffusion therethrough of ammonia molecules, but not of aspartic acid molecules, and a pump for driving said first dialysate around said second cannula circuit.
Claim 3
Dependent Claim
148 words
A blood purification means comprising a first cannula circuit for transport of blood having both ends which are adapted to be connected to the blood stream of a patient to be treated, a hemodialysis unit having a first dialysate provided in said first circuit, the first dialysate containing an asparaginase preparation and being effected with the blood of said first cannula circuit through a semipermeable membrane, a second cannula circuit for transport of the first dialysate of said hemodialysis unit having both ends connected to said hemodialysis unit, a dialyzer having a second dialysate provided in said second cannula, the second dialysate containing additions of fumarate and an asparaginase preparation and being selectively effected with said first dialysate through a semipermeable membrane which permits diffusion therethrough of ammonia molecules, but not of aspartic acid molecules, and a pump for driving said first dialysate around said second cannula circuit.
Claim 4
Dependent Claim
148 words
A blood purification means comprising a first cannula circuit for transport of blood having both ends which are adapted to be connected to the blood stream of a patient to be treated, a hemodialysis unit having a first dialysate provided in said first circuit, the first dialysate containing an asparaginase preparation and being effected with the blood of said first cannula circuit through a semipermeable membrane, a second cannula circuit for transport of the first dialysate of said hemodialysis unit having both ends connected to said hemodialysis unit, a dialyzer having a second dialysate provided in said second cannula, the second dialysate containing additions of fumarate and an asparaginase preparation and being selectively effected with said first dialysate through a semipermeable membrane which permits diffusion therethrough of ammonia molecules, but not of aspartic acid molecules, and a pump for driving said first dialysate around said second cannula circuit.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-06-15 | 1979-12-15 | 1980-06-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-06-15 | 1983-12-15 | 1984-06-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-06-15 | 1987-12-15 | 1988-06-15 | $7700.00 | Window Closed / Lapsed |