US4430229A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Immune adsorbent and adsorbing device
Assignee: Asahi Kasei Corp
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Filing: 1982-05-17
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Granted: 1984-02-07
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Expires: 2002-05-17
Abstract
Abstract An immune adsorbent for autoantibodies and/or immune complexes is provided which is comprised of a water-insoluble carrier and at least one low-molecular-weight substance containing a purine base or pyrimidine base as a constituent element, which is fixed to said carrier. The immune adsorbent is usually used in an adsorption apparatus comprising a vessel having fluid inlet and outlet openings and having packed therein said immune adsorbent.
Inventors
- 👤 Naokuni Yamawaki
- 👤 Katsunori Horikoshi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 06:43
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3679; B; B01; B01J; B01J20/00; B01J20/30; B01J20/32; B01J20/3202; B01J20/3206; B01J20/3208; B01J20/321; B01J20/3231; B01J20/3242; B01J20/3244; B01J20/3246; B01J20/3248; B01J20/3255
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
57 words
An adsorbing material for autoantibodies and immune complexes comprising a water-insoluble carrier, which is a hydroxyl group-containing crosslinked copolymer having a specific surface area of at least 5 m 2 /g, and at least one member selected from low-molecular-weight substances containing a purine base or pyrimidine base as a constituent element, which is fixed to said carrier.
Claim 2
Dependent Claim
57 words
An adsorbing material for autoantibodies and immune complexes comprising a water-insoluble carrier, which is a hydroxyl group-containing crosslinked copolymer having a specific surface area of at least 5 m 2 /g, and at least one member selected from low-molecular-weight substances containing a purine base or pyrimidine base as a constituent element, which is fixed to said carrier.
Claim 3
Dependent Claim
25 words
An adsorbing material as set forth in claim 1, wherein the low-molecular-weight substance is at least one member selected from adenine, guanine, cytosine and uracil.
Claim 4
Dependent Claim
17 words
An adsorbing material as set forth in claim 1, wherein the low-molecular-weight substance is ribonucleoside or deoxyribonucleoside.
Claim 5
Dependent Claim
27 words
An adsorbing material as set forth in claim 1, wherein the hydroxyl group-containing crosslinked copolymer is a crosslinked copolymer comprising vinyl alcohol units as the main constituent.
Claim 6
Dependent Claim
47 words
An adsorbing material as set forth in claim 4, wherein the crosslinked copolymer comprising vinyl alcohol units as the main constituent is a crosslinked polyvinyl alcohol obtained by hydrolyzing a copolymer of a vinyl ester of a carboxylic acid with a vinyl compound having an isocyanurate ring.
Claim 7
Dependent Claim
25 words
An adsorbing material as set forth in claim 1, wherein the hydroxyl group-containing crosslinked copolymer has a hydroxyl group density of 5 to 17 meq/g.
Claim 8
Dependent Claim
29 words
An adsorbing material as set forth in claim 1, wherein the hydroxyl group-containing crosslinked copolymer has a molecular weight exclusion limit for protein of from 150,000 to about 10,000,000.
Claim 9
Independent Claim
83 words
An apparatus for adsorption of autoantibodies and immune complexes, which comprises a vessel having fluid inlet openings and fluid outlet openings and at least one adsorbing material packed in said vessel, said adsorbing material comprising a water-insoluble carrier, which is a hydroxyl group-containing crosslinked copolymer having a specific surface area of at least 5 m 2 /g, and at least one member selected from low-molecular-weight substances containing a purine base or pyrimidine base as a constituent element, which is fixed to said carrier.
Claim 10
Independent Claim
83 words
An apparatus for adsorption of autoantibodies and immune complexes, which comprises a vessel having fluid inlet openings and fluid outlet openings and at least one adsorbing material packed in said vessel, said adsorbing material comprising a water-insoluble carrier, which is a hydroxyl group-containing crosslinked copolymer having a specific surface area of at least 5 m 2 /g, and at least one member selected from low-molecular-weight substances containing a purine base or pyrimidine base as a constituent element, which is fixed to said carrier.
Claim 11
Independent Claim
86 words
A method for removing at least one of an autoantibody and an immune complex from body fluid, comprising contacting body fluid containing at least one of an autoantibody and an immune complex with an adsorbing material comprising a water-insoluble carrier, which is a hydroxyl group-containing crosslinked copolymer having a specific surface area of at least 5 m 2 /g, and at least one member selected from low-molecular weight substances containing a purine base or pyrimidine base as a constituent element, which is fixed to said carrier.
Claim 12
Independent Claim
86 words
A method for removing at least one of an autoantibody and an immune complex from body fluid, comprising contacting body fluid containing at least one of an autoantibody and an immune complex with an adsorbing material comprising a water-insoluble carrier, which is a hydroxyl group-containing crosslinked copolymer having a specific surface area of at least 5 m 2 /g, and at least one member selected from low-molecular weight substances containing a purine base or pyrimidine base as a constituent element, which is fixed to said carrier.
References Cited (Backward Citations)
US3972818A
Cited
US4061591A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-02-06 | 1987-08-08 | 1988-02-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-02-06 | 1991-08-08 | 1992-02-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-02-06 | 1995-08-08 | 1996-02-07 | $7700.00 | Window Closed / Lapsed |