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US4606907A
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Bone seeking Tc-99m complexes of phosphonate derivatives of polyamidoamines
Assignee: Dow Chemical Co
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Filing: 1984-07-02
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Granted: 1986-08-19
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Expires: 2004-07-02
Abstract
Abstract New stable complexing agents for radionuclides which are phosphonate derivatives of certain polyamidoamines have been found which are useful in imaging the skeletal system in animals. Even though the complexing agents have high molecular weights the complexes clear rapidly and very efficiently through the kidneys, with large amounts being taken up in the bone. The ratio of uptake in bone to that in surrounding soft tissue is high even at relatively short times after injection.
Inventors
- 👤 Jaime Simon
- 👤 Wynn A. Volkert
- 👤 David A. Wilson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 09:14
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0489; A61K51/0474; A61K51/0478; A61K2123/00; Y; Y10; Y10S; Y10S424/00; Y10S424/16
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
74 words
A bone seeking complex of a radioactive nuclide and a polymer having the structural formula ##STR2## and wherein the acid groups can be in the form of alkali, alkaline earth or ammonium salts, R and R' are saturated hydrocarbon residues having from 1 to 6 and 1 to 4 carbon atoms, respectively, and m and n are 0 to 10 and wherein at least about 2/3 of Z's are R'PO 3 H 2 .
Claim 2
Dependent Claim
74 words
A bone seeking complex of a radioactive nuclide and a polymer having the structural formula ##STR2## and wherein the acid groups can be in the form of alkali, alkaline earth or ammonium salts, R and R' are saturated hydrocarbon residues having from 1 to 6 and 1 to 4 carbon atoms, respectively, and m and n are 0 to 10 and wherein at least about 2/3 of Z's are R'PO 3 H 2 .
Claim 3
Dependent Claim
17 words
The complex of claim 1 wherein R' is a --CH 2 -- group in the polymer structure.
Claim 4
Dependent Claim
19 words
The complex of claim 2 wherein each of the substituents is a methylenephosphonic acid radical or a salt thereof.
Claim 5
Dependent Claim
22 words
The complex of claim 1 wherein R is a 2-carbon residue, n is 1 and m is 1 in the polymer structure.
Claim 6
Dependent Claim
21 words
The complex of claim 4 wherein R' of the phosphorus-containing group in the polymer structure is a --CH 2 -- group.
Claim 7
Dependent Claim
11 words
The complex of claim 3 wherein the radioactive nuclide is Technetium-99m.
Claim 8
Dependent Claim
11 words
The complex of claim 2 wherein the radioactive nuclide is Technetium-99m.
Claim 9
Dependent Claim
11 words
The complex of claim 4 wherein the radioactive nuclide is Technetium-99m.
Claim 10
Dependent Claim
11 words
The complex of claim 5 wherein the radioactive nuclide is Technetium-99m.
Claim 11
Dependent Claim
16 words
A composition comprising the complex of claim 12 and a reducing agent in a saline solution.
Claim 12
Dependent Claim
16 words
A composition comprising the complex of claim 13 and a reducing agent in a saline solution.
Claim 13
Dependent Claim
16 words
A composition comprising the complex of claim 16 and a reducing agent in a saline solution.
Claim 14
Dependent Claim
16 words
A composition comprising the complex of claim 9 and a reducing agent in a saline solution.
Claim 15
Dependent Claim
13 words
The composition of claim 10 wherein the reducing agent is Sn 2+ .
Claim 16
Dependent Claim
13 words
The composition of claim 11 wherein the reducing agent is Sn 2+ .
Claim 17
Dependent Claim
13 words
The composition of claim 12 wherein the reducing agent is Sn 2+ .
Claim 18
Dependent Claim
13 words
The composition of claim 13 wherein the reducing agent is Sn 2+ .
Claim 19
Dependent Claim
90 words
In a process in which the skeletal system is imaged with a complex of a radioactive nuclide the improvement which comprises employing as the complexing agent a compound having the formula ##STR3## and wherein the acid groups can be in the form of alkali, alkaline earth or ammonium salts, R and R' are saturated hydrocarbon residues having from 1 to 6 and 1 to 4 carbon atoms, respectively, and m and n are 0 to 10 and wherein at least about 2/3 of Z's are R'PO 3 H 2 .
Claim 20
Dependent Claim
90 words
In a process in which the skeletal system is imaged with a complex of a radioactive nuclide the improvement which comprises employing as the complexing agent a compound having the formula ##STR3## and wherein the acid groups can be in the form of alkali, alkaline earth or ammonium salts, R and R' are saturated hydrocarbon residues having from 1 to 6 and 1 to 4 carbon atoms, respectively, and m and n are 0 to 10 and wherein at least about 2/3 of Z's are R'PO 3 H 2 .
Claim 21
Dependent Claim
19 words
The process of claim 18 wherein each of the substituents is a methylenephosphonic acid radical or a salt thereof.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-08-18 | 1990-02-17 | 1990-08-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-08-18 | 1994-02-17 | 1994-08-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-08-18 | 1998-02-17 | 1998-08-19 | $7700.00 | Window Closed / Lapsed |