US4515766A
Expired / Lapsed
US
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Labeled phosphonic acid compositions for investigations of in vivo deposits of calcium
Assignee: General Hospital Corp
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Filing: 1982-06-30
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Granted: 1985-05-07
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Expires: 2002-06-30
Abstract
Abstract The composition and methodology associated with the formulation of a halogenated phosphonic acid labeled in the ring moiety are disclosed having the formula: <IMAGE> wherein R1 is aryl and is labeled with a halogen and R2 is hydrogen, alkyl, alkenyl, amino, benzyl, hydroxyl-CH2PO3H -CH2CH2PO3H2 and is labeled with halogen. The compositions are especially useful for scanning investigations of in vivo deposits of calcium.
Inventors
- 👤 Frank P. Castronovo
- 👤 Harry W. Strauss
- 👤 Majic S. Potsaid
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 22:53
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0489; A61K2123/00
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
78 words
A composition of matter comprising a radiolabeled, with a radioisotope, diphosphonic acid, said diphosphonic acid represented by the formula: ##STR5## wherein: R 1 is aryl and is labeled with a halogen and R 2 is hydrogen, alkyl, alkenyl, amine, benzyl, hydroxyl, --CH 2 PO 3 H --CH 2 CH 2 PO 3 H 2 and is labeled with halogen, said radiolabel selected from the group consisting of a radioactive halogen and both a radioactive halogen and a technetium-99m.
Claim 2
Dependent Claim
78 words
A composition of matter comprising a radiolabeled, with a radioisotope, diphosphonic acid, said diphosphonic acid represented by the formula: ##STR5## wherein: R 1 is aryl and is labeled with a halogen and R 2 is hydrogen, alkyl, alkenyl, amine, benzyl, hydroxyl, --CH 2 PO 3 H --CH 2 CH 2 PO 3 H 2 and is labeled with halogen, said radiolabel selected from the group consisting of a radioactive halogen and both a radioactive halogen and a technetium-99m.
Claim 3
Dependent Claim
15 words
The composition of claim 1 wherein said diphosphonic acid is phenyl methylene hydroxy diphosphonic acid.
Claim 4
Dependent Claim
16 words
The composition of claim 1 wherein the diphosphonic acid is methylene hydroxyphenyl methylene hydroxy diphosphonic acid.
Claim 5
Dependent Claim
21 words
The composition of any one of claims 1, 2 or 3 wherein said radiolabel is both a radioactive halogen and technetium-99m.
Claim 6
Dependent Claim
16 words
The composition of any one of claims 1, 2 or 3 wherein said radiolabel is iodine-123.
Claim 7
Dependent Claim
16 words
The composition of any one of claims 1, 2 or 3 wherein said radiolabel is iodine-125.
Claim 8
Dependent Claim
16 words
The composition of any one of claims 1, 2 or 3 wherein said radiolabel is iodine-131.
Claim 9
Dependent Claim
48 words
The process for monitoring the metabolism of areas of the body having a high calcium ion concentration in a human which comprises injecting into the human the composition of claim 1 and monitoring the biodistribution of the labeled composition and resorptive rates of said agent from bony sites.
Claim 10
Dependent Claim
18 words
The process of claim 8 wherein said phosphonic acid is radiolabeled with both a radioactive halogen and technetium-99m.
Claim 11
Dependent Claim
13 words
The process of claim 8 wherein said phosphonic acid is radiolabeled with iodine-123.
Claim 12
Dependent Claim
13 words
The process of claim 8 wherein said phosphonic acid is radiolabeled with iodine-125.
Claim 13
Dependent Claim
13 words
The process of claim 8 wherein said phosphonic acid is radiolabeled with iodine-131.
Claim 14
Dependent Claim
73 words
A diagnostic kit suitable for forming a composition useful for monitoring areas of the body having a high calcium ion concentration which comprises a sterile package containing a diphosphonic acid of the formula: ##STR6## wherein: R 1 is aryl and is labeled with a halogen and R 2 is hydrogen, alkyl, alkenyl, amine, benzyl, hydroxyl, --CH 2 PO 3 H --CH 2 CH 2 PO 3 H 2 and is labeled with halogen.
Claim 15
Dependent Claim
73 words
A diagnostic kit suitable for forming a composition useful for monitoring areas of the body having a high calcium ion concentration which comprises a sterile package containing a diphosphonic acid of the formula: ##STR6## wherein: R 1 is aryl and is labeled with a halogen and R 2 is hydrogen, alkyl, alkenyl, amine, benzyl, hydroxyl, --CH 2 PO 3 H --CH 2 CH 2 PO 3 H 2 and is labeled with halogen.
Claim 16
Dependent Claim
27 words
The kit of claim 14 wherein a physiologically acceptable reducing agent useful in reducing technetium (VII) to the technetium (IV) state is admixed with said diphosphonic acid.
Claim 17
Dependent Claim
15 words
The kit of claim 14 wherein said diphosphonic acid in said sterile package is lyophilized.
Claim 18
Dependent Claim
17 words
The kit of claim 14 which includes an ion exchange resin capable of purifying said radiolabeled composition.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-05-06 | 1988-11-05 | 1989-05-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-05-06 | 1992-11-05 | 1993-05-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-05-06 | 1996-11-05 | 1997-05-07 | $7700.00 | Window Closed / Lapsed |