US4234562A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Radiographic scanning
Assignee: Mallinckrodt Inc
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Filing: 1978-03-20
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Granted: 1980-11-18
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Expires: 1998-03-20
Abstract
Abstract A composition and method for the preparation of a technetium-99 m based scintigraphic scanning agent are disclosed. The agent is prepared by the addition of a pertechnetate-99 m solution to an anhydrous salt composition comprising a phosphonic acid or a pharmaceutically acceptable salt thereof and a non-toxic, water-soluble, anhydrous, stannous, ferrous or chromous salt of hydrochloric or sulfuric acid.
Inventors
- 👤 Andrew J. Tofe
- 👤 Marion D. Francis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 10:51
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0489; A61K2123/00
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
72 words
A composition for the preparation of an improved bone scanning agent comprising a dry mixture of: (a) methanehydroxydiphosphonic acid and pharmaceutically-acceptable salts, and mixtures of salts, thereof; and (b) an amount of an anhydrous hydrochloric or sulfuric acid salt of a metal selected from the group consisting of ferrous, chromous and stannous and mixtures thereof sufficient to produce a molar ratio of metal to phosphonate of from about 1:15 to about 1:80.
Claim 2
Dependent Claim
72 words
A composition for the preparation of an improved bone scanning agent comprising a dry mixture of: (a) methanehydroxydiphosphonic acid and pharmaceutically-acceptable salts, and mixtures of salts, thereof; and (b) an amount of an anhydrous hydrochloric or sulfuric acid salt of a metal selected from the group consisting of ferrous, chromous and stannous and mixtures thereof sufficient to produce a molar ratio of metal to phosphonate of from about 1:15 to about 1:80.
Claim 3
Dependent Claim
18 words
A composition according to claim 1 wherein the phosphonate is a sodium salt or mixture of sodium salts.
Claim 4
Dependent Claim
18 words
A composition according to claim 2 wherein the phosphonate is a mixture of disodium and trisodium methanehydroxydiphosphonate salts.
Claim 5
Dependent Claim
12 words
A composition according to claim 1 wherein the metal ion is stannous.
Claim 6
Dependent Claim
13 words
A composition according to claim 4 wherein the metal salt is stannous chloride.
Claim 7
Dependent Claim
17 words
A composition according to claim 1 which additionally contains about 1 to 50 parts of sodium chloride.
Claim 8
Dependent Claim
144 words
A composition for the preparation of an improved bone scanning agent comprising a dry mixture of: (a) a phosphonate selected from the group consisting of: ##STR8## wherein each R is hydrogen or CH 2 OH and n is an integer of from 3 to 10; ##STR9## wherein n is an integer of from 3 to 9; ##STR10## wherein each R 3 is hydrogen or lower alkyl; ##STR11## wherein n is an integer of from 2 to 4; ##STR12## wherein X and Y are each hydrogen or hydroxy; and the pharmaceutically-acceptable salts of each of the foregoing acids and mixtures thereof; and (b) an amount of an anhydrous hydrochloric or sulfuric acid salt of a metal selected from the group consisting of ferrous, chromous and stannous and mixtures thereof sufficient to produce a molar ratio of metal to phosphonate of from about 1:15 to 1:80.
Claim 9
Dependent Claim
144 words
A composition for the preparation of an improved bone scanning agent comprising a dry mixture of: (a) a phosphonate selected from the group consisting of: ##STR8## wherein each R is hydrogen or CH 2 OH and n is an integer of from 3 to 10; ##STR9## wherein n is an integer of from 3 to 9; ##STR10## wherein each R 3 is hydrogen or lower alkyl; ##STR11## wherein n is an integer of from 2 to 4; ##STR12## wherein X and Y are each hydrogen or hydroxy; and the pharmaceutically-acceptable salts of each of the foregoing acids and mixtures thereof; and (b) an amount of an anhydrous hydrochloric or sulfuric acid salt of a metal selected from the group consisting of ferrous, chromous and stannous and mixtures thereof sufficient to produce a molar ratio of metal to phosphonate of from about 1:15 to 1:80.
Claim 10
Dependent Claim
11 words
The composition of claim 7 wherein the metal ion is stannous.
Claim 11
Dependent Claim
12 words
The composition of claim 8 wherein the metal salt is stannous chloride.
Claim 12
Dependent Claim
16 words
The composition of claim 9 which additionally contains about 1 to 50 parts of sodium chloride.
Claim 13
Independent Claim
23 words
A method for preparing an improved bone scanning agent comprising adding a pertechnetate solution to the dry mixture of claims 1 or 7.
References Cited (Backward Citations)
US3983227A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-11-18 | 1984-05-19 | 1984-11-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-11-18 | 1988-05-19 | 1988-11-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-11-18 | 1992-05-19 | 1992-11-18 | $7700.00 | Window Closed / Lapsed |