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US4104366A
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Compositions for preparation of aqueous solutions of low valence 99 technitium salts
Assignee: Henkel AG and Co KGaA
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Filing: 1976-09-23
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Granted: 1978-08-01
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Expires: 1996-09-23
Abstract
Abstract Aqueous solutions of 99 technetium salts wherein the 99 technetium is in reduced valencey state, when administered to mammals, permit identification of the skeleton and of calcareous tumors by scintigraphy (radiographic scanning). The solutions are conveniently prepared by mixing one or more phosphonic acids (or their salts) with one or more reducing salts, and adding the mixture to an aqueous solution of a pharmaceutically acceptable 99 pertechnetate salt. Reduction of the valence of the technetium occurs rapidly, and the resulting solution is adequately stable for use in scintigraphy. The phosphonic acid and reducing salt components can be premixed. Aqueous solutions of the premix are stable for long periods of time in the absence of free oxygen and the premix is stable to air so long as it is dry.
Inventors
- 👤 Manfred Schmidt-Dunker
- 👤 Wolfgang Greb
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 19:09
CPC Classifications
G; G21; G21H; G21H5/00; G21H5/02; A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0489; A61K2123/00
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
159 words
A composition for use in the preparation of aqueous solution containing 99m technetium for use in the detection by scintography of bones and calcareous tumors, comprising: (A) one or more water-soluble phosphonic compounds of the formulae: ##STR7## wherein R represents a substituent from the group consisting of H and C 1-6 alkyl; ##STR8## wherein R represents a substituent from the group consisting of H and C 1-4 alkyl; ##STR9## wherein R represents a substituent from the group consisting of H and C 1-6 alkyl; ##STR10## wherein R represents a substituent from the group consisting of H and C 1-6 ; ##STR11## wherein R represents a substituent from the group consisting of H and C 1-4 alkyl; Vi the pharmaceutically-acceptable water-soluble salts of the above acids (I)--(V); and (B) a pharmaceutically acceptable water-soluble salt selected from the group consisting of tin (II), iron (II) and chromium (II) salts and mixtures thereof in less than stoichiometric quantity relative to component (A).
Claim 2
Dependent Claim
159 words
A composition for use in the preparation of aqueous solution containing 99m technetium for use in the detection by scintography of bones and calcareous tumors, comprising: (A) one or more water-soluble phosphonic compounds of the formulae: ##STR7## wherein R represents a substituent from the group consisting of H and C 1-6 alkyl; ##STR8## wherein R represents a substituent from the group consisting of H and C 1-4 alkyl; ##STR9## wherein R represents a substituent from the group consisting of H and C 1-6 alkyl; ##STR10## wherein R represents a substituent from the group consisting of H and C 1-6 ; ##STR11## wherein R represents a substituent from the group consisting of H and C 1-4 alkyl; Vi the pharmaceutically-acceptable water-soluble salts of the above acids (I)--(V); and (B) a pharmaceutically acceptable water-soluble salt selected from the group consisting of tin (II), iron (II) and chromium (II) salts and mixtures thereof in less than stoichiometric quantity relative to component (A).
Claim 3
Dependent Claim
23 words
A composition according to claim 1, wherein the weight of component (B) is 1% to 5% of the weight of said component (A).
Claim 4
Dependent Claim
14 words
A composition according to claim 1 wherein the phosphonic compound is a partial salt.
Claim 5
Dependent Claim
32 words
A composition according to claim 1 in which component (A) contains a compound from the group consisting of the cyclic aminophosphonic acid of the formula ##STR12## and a partial sodium salt thereof.
Claim 6
Dependent Claim
25 words
A composition according to claim 1 wherein component (A) contains a compound from the group consisting of azacycloheptane-2,2-diphosphonic acid and a partial sodium salt thereof.
Claim 7
Dependent Claim
14 words
A composition according to claim 1 wherein the component (B) is tin (II) chloride.
Claim 8
Dependent Claim
11 words
A composition according to claim 1 in dry mix tableted form.
Claim 9
Dependent Claim
18 words
A composition according to claim 1 in unit dosage form in an ampoule containing substantially no free oxygen.
Claim 10
Dependent Claim
22 words
A composition according to claim 1 in unit dosage form and in lyophilized state in an ampoule containing substantially no free oxygen.
Claim 11
Dependent Claim
64 words
A method of preparing a stable solution of a water-soluble salt of 99 m technetium which is absorbed by bone and by calcareous tumors in mammals, which comprises adding to an aqueous solution of a 99 m pertechnetate salt a sufficient amount of a phosphonic acid-reducing agent composition according to claim 1 to reduce the technetium in said pertechnetate salt to a lower valency.
Claim 12
Dependent Claim
20 words
A method according to claim 10 wherein the said phosphonic acid reducing agent composition is added in dry tableted form.
Claim 13
Dependent Claim
38 words
A method according to claim 10 wherein the amount of said phosphonic acid reducing agent composition is added in excess of the amount which reduces substantially all of the technetium in said pertechnetate salt to a lower valence.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-07-31 | 1982-01-30 | 1982-08-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-07-31 | 1986-01-30 | 1986-08-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-07-31 | 1990-01-30 | 1990-08-01 | $7700.00 | Window Closed / Lapsed |