US3974268A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Bone-seeking technetium-99m imidodiphosphonate complex
Assignee: Research Corp
•
Filing: 1975-05-30
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Granted: 1976-08-10
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Expires: 1995-05-30
Abstract
Abstract Technetium-99m-imido disphosphonate complex useful as a skeletal-imaging agent, particularly useful for diagnostic purposes.
Inventors
- 👤 Gopal Subramanian
- 👤 John Gilmore McAfee
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 11:08
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0489; A61K2123/00
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
15 words
A bone-seeking composition suitable for use as a skeletal imaging agent comprising a technetium-99m-tin-imidodiphosphonate complex.
Claim 2
Dependent Claim
15 words
A bone-seeking composition suitable for use as a skeletal imaging agent comprising a technetium-99m-tin-imidodiphosphonate complex.
Claim 3
Dependent Claim
3 words
Stannous imidodiphosphonate complex.
Claim 4
Dependent Claim
3 words
Stannous imidodiphosphonate complex.
Claim 5
Dependent Claim
16 words
A bone-seeking composition comprising a solution adapted for intravenous administration containing the composition of claim 1.
Claim 6
Dependent Claim
14 words
The composition of claim 3 in unit dosage form containing 5-20 mCi of radioactivity.
Claim 7
Dependent Claim
33 words
A method of preparing the composition of claim 1 comprising reducing a technetium-99m containing pertechnetate salt with stannous ion in an aqueous medium in the presence of imidodiphosphonic acid or a salt thereof.
Claim 8
Dependent Claim
25 words
The method of claim 5 comprising admixing in aqueous solution imidodiphosphonic acid or a salt thereof, a stannous salt and a technetium-99m containing pertechnetate salt.
Claim 9
Dependent Claim
20 words
The method of claim 5 comprising admixing technetium-99m containing pertechnetate salt with a stannous imidodiphosphonate complex in an aqueous medium.
Claim 10
Dependent Claim
14 words
The method of claim 5 wherein said pertechnetate salt is an alkali metal salt.
Claim 11
Dependent Claim
22 words
A method of skeletal-imaging which includes the intravenous administration of a solution adapted for intravenous administration containing the composition of claim 1.
Claim 12
Dependent Claim
25 words
The method of claim 9 wherein said solution is in unit dosage form of from 1 to 5 ml and contains 5-20 mCi of radioactivity.
Claim 13
Dependent Claim
31 words
The method of claim 10 wherein from about 0.05 to about 0.5 mg of complex are administered per kg of body weight, based on the weight of the free imidodiphosphonic acid.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-08-10 | 1980-02-09 | 1980-08-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-08-10 | 1984-02-09 | 1984-08-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-08-10 | 1988-02-09 | 1988-08-10 | $7700.00 | Window Closed / Lapsed |