Stannous pyrophosphate technetium-99m compositions

Claim 2

An improved composition for skeletal imaging comprising, A. divalent tin B. technetium-99m C. pyrophosphate, and D. sufficient ascorbate to reduce (1) the oxidation of Sn +2 to Sn +4 during extended storage and (2) reoxidation of reduced technetium and the formation of technetium labeled impurities.

Claim 3

A composition according to claim 1 additionally containing perchlorate.

Claim 4

An improved lyophilized composition for use in preparing bone scanning agents comprising, A. divalent tin B. pyrophosphate, and C. sufficient ascorbate to reduce (1) the oxidation of Sn +2 to Sn +4 during extended storage and (2) reoxidation of reduced technetium and the formation of technetium labeled impurities.

Claim 5

An improved lyophilized composition for use in preparing bone scanning agents comprising, A. divalent tin B. pyrophosphate, and C. sufficient ascorbate to reduce (1) the oxidation of Sn +2 to Sn +4 during extended storage and (2) reoxidation of reduced technetium and the formation of technetium labeled impurities.

Claim 6

A composition according to claim 3 additionally containing perchlorate.

Claim 7

In a method for bone imaging wherein a bone imaging agent is injected and thereafter a scan made, the improvement comprising using as the bone imaging agent the composition of claim 1.

Claim 8

In a method for bone imaging wherein a bone imaging agent is injected and thereafter a scan made, the improvement comprising using as the bone imaging agent the composition of claim 2.

Claim 9

A lyophilized composition according to claim 3, wherein the divalent tin and pyrophosphate are present in an amount such that the molar ratio of Sn/P 2 O 7 is in the range of about 0.010/1.0 to about 0.58/1.0 and the ascorbate is present in an amount of from about .1mg to 2.5mg per mg of divalent tin.

Claim 10

A lyophilized composition according to claim 7 wherein the divalent tin and pyrophosphate are present in an amount such that the molar ratio of Sn/P 2 O 7 is in the range of about 0.02/1.0 to about 0.06/1.0 and the ascorbate is present in an amount of from about 0.21mg to about 1.2mg per mg of divalent tin.

Claim 11

An improved lyophilized composition for use in preparing bone scanning agents consisting essentially of stannous chloride, sodium pyrophosphate and ascorbaic acid, the molar ratio of Sn/P 2 O 7 being in the range of about 0.02/1 to about 0.06/1 and the ascorbic acid being present in an amount to provide about .21mg to about 1.2mg of ascorbate per mg of divalent tin.

Claim 12

An improved lyophilized composition for use in preparing bone scanning agents consisting essentially of stannous chloride, sodium pyrophosphate and ascorbaic acid, the molar ratio of Sn/P 2 O 7 being in the range of about 0.02/1 to about 0.06/1 and the ascorbic acid being present in an amount to provide about .21mg to about 1.2mg of ascorbate per mg of divalent tin.

Claim 13

An improved composition for skeletal imaging comprising a sterile aqueous solution containing divalent tin, technetium 99m, pyrophosphate and ascorbate, the divalent tin and pyrophosphate being present in an amount such that the molar ratio of Sn/P 2 O 7 is in the range of about 0.010/1 to about 0.58/1, the technetium 99m being present in an amount such that the ratio of P 2 O 7 /technetium 99m is in the range of about 0.012mg/mCi to about 4mg/mCi and the ascorbate being present in an amount of about 0.1mg to about 2.5mg per mg of divalent tin.

Claim 14

An improved composition for skeletal imaging comprising a sterile aqueous solution containing divalent tin, technetium 99m, pyrophosphate and ascorbate, the divalent tin and pyrophosphate being present in an amount such that the molar ratio of Sn/P 2 O 7 is in the range of about 0.010/1 to about 0.58/1, the technetium 99m being present in an amount such that the ratio of P 2 O 7 /technetium 99m is in the range of about 0.012mg/mCi to about 4mg/mCi and the ascorbate being present in an amount of about 0.1mg to about 2.5mg per mg of divalent tin.

Claim 15

A composition according to claim 10 wherein the divalent tin and pyrophosphate are present in an amount such that the molar ratio of Sn/P 2 O 7 is in the range of about 0.02/1 to about 0.06/1 and the technetium 99m is present such that the ratio of P 2 O 7 /technetium 99m is in the range of about 0.03mg/mCi to about 1.2mg/mCi and the ascorbate is present in an amount of about 0.21mg to about 1.2mg per mg of divalent tin.

Claim 16

An improved composition for skeletal imaging comprising a sterile aqueous solution consisting essentially of stannous chloride, technetium 99m, sodium pyrophosphate and ascorbic acid, the divalent tin and sodium pyrophosphate being present in an amount such that the molar ratio of Sn/P 2 O 7 is in the range of about 0.02/1 to about 0.06/1, the technetium 99m is present such that the ratio of P 2 O 7 /technetium 99m is in the range of about 0.03mg/mCi to about 1.2mg/mCi and the ascorbic acid is present in an amount to provide from about 0.21 mg to about 1.2 mg of ascorbate per mg of divalent tin.

Claim 17

An improved composition for skeletal imaging comprising a sterile aqueous solution consisting essentially of stannous chloride, technetium 99m, sodium pyrophosphate and ascorbic acid, the divalent tin and sodium pyrophosphate being present in an amount such that the molar ratio of Sn/P 2 O 7 is in the range of about 0.02/1 to about 0.06/1, the technetium 99m is present such that the ratio of P 2 O 7 /technetium 99m is in the range of about 0.03mg/mCi to about 1.2mg/mCi and the ascorbic acid is present in an amount to provide from about 0.21 mg to about 1.2 mg of ascorbate per mg of divalent tin.

Claim 18

In a method for bone imaging wherein a bone imaging agent is injected and thereafter a scan made, the improvement comprising using as the bone imaging agent the composition of claim 10.

Claim 19

In a method for bone imaging wherein a bone imaging agent is injected and thereafter a scan made, the improvement comprising using as the bone imaging agent the composition of claim 12.

Claim 20

A composition according to claim 8 additionally containing perchlorate in an amount of about 20 mg to 30 mg per mg of divalent tin.

Claim 21

A composition according to claim 11 additionally containing perchlorate in an amount of about 20 mg to 30 mg per mg of divalent tin.