US6685648B2
Expired / Lapsed
US
⏱️ 0.0 years remaining
Systems and methods for delivering drugs to selected locations within the body
Assignee: Medtronic Vascular Inc
•
Filing: 2001-04-03
•
Granted: 2004-02-03
•
Expires: 2021-04-03
Abstract
Abstract A method is provided for delivering a drug to a selected tissue region within a patient's body with a catheter having a deployable puncturing element, a drug delivery element and an orientation element on a distal portion thereof. The distal portion of the catheter is percutaneously introduced into a blood vessel, and directed endovascularly to a vessel location adjacent to the selected tissue region. The puncturing element is oriented towards the selected tissue region, and deployed to access the selected tissue region. A drug is delivered with the drug delivery element to the selected tissue region.
Inventors
- 👤 J. Christopher Flaherty
- 👤 Joshua Makower
- 👤 Philip C. Evard
- 👤 Patrick E. Macaulay
- 👤 Jason B. Whitt
- 👤 Robert C. Colloton
- 👤 K. Angela Macfarlane
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 00:53
CPC Classifications
A; A61; A61M; A61M25/00; A61M25/0067; A61M25/0082; A61M25/0084; A61B; A61B17/00; A61B17/11; A61B17/12; A61B17/12022; A61B17/12027; A61B17/1204; A61B17/12045; A61B17/12099; A61B17/12109; A61B17/12131; A61B17/12136; A61B17/12168; A61B17/12172; A61B17/34; A61B17/3417; A61M25/0068; A61M25/01; A61M25/0105; A61M25/0108; A61M5/00; A61M5/007; A61M5/46; A61B17/00491; A61B17/064; A61B17/0643; A61B17/22; A61B18/00; A61B18/04; A61B18/12; A61B18/14; A61B18/1477; A61B18/1492; A61B17/00234; A61B2017/00238; A61B2017/00243; A61B2017/00247; A61B2017/00252; A61B2017/00504; A61B2017/1107; A61B2017/1139; A61B2017/12127; A61B2017/22072; A61B2017/22074; A61B2017/22077; A61B17/30; A61B2017/306; A61B2017/347; A61B2018/00315; A61B2018/00345; A61B2018/00351; A61B2018/00392; A61B2018/1405; A61B2018/1425; A61B8/00; A61B8/12; A61B90/00; A61B90/40; A61F; A61F2/00; A61F2/02; A61F2/24; A61F2/2493; A61F2/30; A61F2002/30001; A61F2002/30003; A61F2002/3006; A61F2002/30079; A61F2210/00; A61F2210/009; A61M25/0021; A61M25/0023; A61M25/0026; A61M2025/0037; A61M25/0074; A61M25/0075; A61M2025/0076; A61M2025/0085; A61M2025/0086; A61M2025/0087; A61M2025/0089; A61M2025/009; A61M2025/0096; A61M25/10; A61M2025/1043; A61M2025/1052; A61M25/0069; A61M25/007; A61M39/00; A61M39/02; A61M39/0208; A61M39/04
Claims Analysis
Total Claims: 37
Claim 1
Independent Claim
119 words
A method of delivering a drug to a selected tissue region within a patient's body with a catheter having a deployable puncturing element, a drug delivery element and an orientation element on a distal portion thereof, the method comprising: percutaneously introducing the distal portion of the catheter into a blood vessel; directing the distal portion endovascularly to a vessel location adjacent to the selected tissue region; rotating the catherer about its longitudinal axis while using the orientation element to orient the puncturing element towards the selected tissue region; deploying the puncturing element through a wall of the vessel location to access the selected tissue region; and delivering a drug with the drug delivery element to the selected tissue region.
Claim 2
Independent Claim
119 words
A method of delivering a drug to a selected tissue region within a patient's body with a catheter having a deployable puncturing element, a drug delivery element and an orientation element on a distal portion thereof, the method comprising: percutaneously introducing the distal portion of the catheter into a blood vessel; directing the distal portion endovascularly to a vessel location adjacent to the selected tissue region; rotating the catherer about its longitudinal axis while using the orientation element to orient the puncturing element towards the selected tissue region; deploying the puncturing element through a wall of the vessel location to access the selected tissue region; and delivering a drug with the drug delivery element to the selected tissue region.
Claim 3
Dependent Claim
13 words
The method of claim 1 , wherein the blood vessel comprises a vein.
Claim 4
Dependent Claim
26 words
The method of claim 1 , wherein the blood vessel comprises a coronary vein, and the selected tissue region comprises myocardial tissue or a coronary artery.
Claim 5
Dependent Claim
18 words
The method of claim 1 , wherein the orienting step includes the step of imaging the orientation element.
Claim 6
Dependent Claim
27 words
The method of claim 4 , wherein the orientation element has a predetermined circumferential relationship about a periphery of the catheter with respect to the puncturing element.
Claim 7
Dependent Claim
29 words
The method of claim 4 , wherein the catheter includes an imaging element adjacent the orientation element, and the imaging step includes the step of operating the imaging element.
Claim 8
Dependent Claim
47 words
The method of claim 6 , wherein the imaging element comprises an ultrasound transducer, and the step of operating the imaging element includes the step of obtaining an image slice including the selected tissue region along a plane substantially normal to a longitudinal axis of the catheter.
Claim 9
Dependent Claim
38 words
The method of claim 1 , wherein the puncturing element comprises a needle, and wherein the deploying step includes penetrating a wall of the blood vessel and entering the tissue region with a distal tip of the needle.
Claim 10
Dependent Claim
24 words
The method of claim 1 , further comprising the step of mapping the selected tissue region prior to the step of delivering a drug.
Claim 11
Dependent Claim
20 words
The method of claim 9 , wherein the mapping step includes introducing a radiographic agent into the selected tissue region.
Claim 12
Dependent Claim
25 words
The method of claim 1 , wherein the delivering step includes the step of deploying the drug delivery element in combination with the puncturing element.
Claim 13
Dependent Claim
15 words
The method of claim 11 , wherein the drug delivery element comprises an infusion catheter.
Claim 14
Dependent Claim
22 words
The method of claim 12 , wherein the delivering step includes the step of inflating a porous balloon on the infusion catheter.
Claim 15
Dependent Claim
33 words
The method of claim 1 , further comprising the steps of: delivering an ablation element to the tissue region; and activating the ablation element to create a drug reservoir within the tissue region.
Claim 16
Dependent Claim
30 words
The method of claim 14 , wherein the step of delivering the ablation element includes the step of advancing the ablation element over the puncturing element into the tissue region.
Claim 17
Independent Claim
120 words
A method of providing access to a selected tissue region within a patient's body from a blood vessel using a transvascular catheter having a deployable puncturing element, and an orientation element on a distal portion thereof, the method comprising: percutaneously introducing the distal portion of the transvascular catheter into a blood vessel; directing the distal portion endovascularly to a vessel location adjacent to the selected tissue region; orienting the puncturing element towards the selected tissue region using the orientation element; deploying the puncturing element to access the selected tissue region; advancing a floppy catheter into the selected tissue region via the transvascular catheter; and removing the transvascular catheter from the body, leaving the floppy catheter in the selected tissue region.
Claim 18
Independent Claim
120 words
A method of providing access to a selected tissue region within a patient's body from a blood vessel using a transvascular catheter having a deployable puncturing element, and an orientation element on a distal portion thereof, the method comprising: percutaneously introducing the distal portion of the transvascular catheter into a blood vessel; directing the distal portion endovascularly to a vessel location adjacent to the selected tissue region; orienting the puncturing element towards the selected tissue region using the orientation element; deploying the puncturing element to access the selected tissue region; advancing a floppy catheter into the selected tissue region via the transvascular catheter; and removing the transvascular catheter from the body, leaving the floppy catheter in the selected tissue region.
Claim 19
Dependent Claim
26 words
The method of claim 16 , comprising the additional step of advancing a guide wire into the selected tissue region in conjunction with the puncturing element.
Claim 20
Dependent Claim
28 words
The method of claim 17 , wherein the step of advancing a floppy catheter comprises tracking the floppy catheter over the guide wire into the selected tissue region.
Claim 21
Dependent Claim
27 words
The method of claim 16 , comprising the additional step of securing a proximal end of the floppy catheter to a surface location of the patient's body.
Claim 22
Dependent Claim
23 words
The method of claim 16 , comprising the additional step of delivering a drug through the floppy catheter into the selected tissue region.
Claim 23
Dependent Claim
13 words
The method of claim 16 , wherein the blood vessel comprises a vein.
Claim 24
Dependent Claim
27 words
The method of claim 16 , wherein the blood vessel comprises a coronary vein, and wherein the selected tissue region comprises myocardial tissue or a coronary artery.
Claim 25
Independent Claim
122 words
A method for delivering a substance to a selected tissue region within a patient's body with a catheter having a deployable puncturing element, a drug delivery element, an orientation element, and an imaging clement carried by a distal portion of the catheter, the method comprising: percutaneously introducing the distal portion of the catheter into a blood vessel; directing the distal portion endovascularly to a vessel location adjacent to the selected tissue region; rotating the catheter about its longitudinal axis while imaging the orientation element with the imaging element to orient the puncturing element towards the selected tissue region; deploying the puncturing element to access the selected tissue region; and delivering a substance with the drug delivery element to the selected tissue region.
Claim 26
Independent Claim
122 words
A method for delivering a substance to a selected tissue region within a patient's body with a catheter having a deployable puncturing element, a drug delivery element, an orientation element, and an imaging clement carried by a distal portion of the catheter, the method comprising: percutaneously introducing the distal portion of the catheter into a blood vessel; directing the distal portion endovascularly to a vessel location adjacent to the selected tissue region; rotating the catheter about its longitudinal axis while imaging the orientation element with the imaging element to orient the puncturing element towards the selected tissue region; deploying the puncturing element to access the selected tissue region; and delivering a substance with the drug delivery element to the selected tissue region.
Claim 27
Dependent Claim
13 words
The method of claim 23 , wherein the blood vessel comprises a vein.
Claim 28
Dependent Claim
26 words
The method of claim 23 , wherein the blood vessel comprises a coronary vein, and tbe selected tissue region comprises myocardial tissue or a coronary artery.
Claim 29
Dependent Claim
39 words
The method of claim 23 , wherein the puncturing element comprises a needle, and wherein the deploying step includes penetrating through a wall of the blood vessel and entering the tissue region with a distal tip of the needle.
Claim 30
Dependent Claim
25 words
The method of claim 23 , wherein the delivering step includes the step of deploying the drug delivery element in combination with the puncturing element.
Claim 31
Dependent Claim
15 words
The method of claim 27 , wherein the drug delivery element comprises an infusion catheter.
Claim 32
Dependent Claim
22 words
The method of claim 28 , wherein the delivering step includes the step of inflating a porous balloon on the infusion catheter.
Claim 33
Dependent Claim
33 words
The method of claim 23 , further comprising the steps of: delivering an ablation element to the tissue region; and activating the ablation element to create a drug reservoir within the tissue region.
Claim 34
Dependent Claim
30 words
The method of claim 30 , wherein the step of delivering the ablation element includes the step of advancing the ablation element over the puncturing element into the tissue region.
Claim 35
Independent Claim
125 words
A method for delivering a substance within a patient's heart with a catheter having a puncturing element, a drug delivery element, and an orientation element on a distal portion thereof, the method comprising: percutaneously introducing the distal portion of the catheter into a blood vessel; directing the distal portion endovascularly into a coronary vein or a coronary artery adjacent to a selected tissue region located beyond a wall of the coronary vein or coronary artery; orienting the puncturing element towards the selected tissue region using the orientation element: deploying the puncturing element from the catheter through the wall of the coronary vein or coronary artery to access the selected tissue region; and delivering a substance with the drug delivery element to the selected tissue region.
Claim 36
Independent Claim
125 words
A method for delivering a substance within a patient's heart with a catheter having a puncturing element, a drug delivery element, and an orientation element on a distal portion thereof, the method comprising: percutaneously introducing the distal portion of the catheter into a blood vessel; directing the distal portion endovascularly into a coronary vein or a coronary artery adjacent to a selected tissue region located beyond a wall of the coronary vein or coronary artery; orienting the puncturing element towards the selected tissue region using the orientation element: deploying the puncturing element from the catheter through the wall of the coronary vein or coronary artery to access the selected tissue region; and delivering a substance with the drug delivery element to the selected tissue region.
Claim 37
Dependent Claim
30 words
The method of claim 32 , wherein the catheter is rotated about its longitudinal axis while using the otientation element to orient the puncturing element towards the selected tissue region.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2007-02-02 | 2007-08-04 | 2008-02-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2011-02-02 | 2011-08-04 | 2012-02-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2015-02-02 | 2015-08-04 | 2016-02-03 | $7700.00 | Window Closed / Lapsed |