US5772629A — Localized intravascular delivery of TFPI for inhi…

Claim 1

Independent Claim 37 words

A method for inhibiting abrupt closure and restenosis in a recanalized blood vessel, said method comprising intramurally delivering a TFPI polypeptide to a target site within the blood vessel in an amount sufficient to reduce platelet deposition.

Claim 2

Independent Claim 37 words

A method for inhibiting abrupt closure and restenosis in a recanalized blood vessel, said method comprising intramurally delivering a TFPI polypeptide to a target site within the blood vessel in an amount sufficient to reduce platelet deposition.

Claim 3

Dependent Claim 25 words

A method as in claim 1, wherein the amount of the TFPI polypeptide is from 0.1 μg to 10 mg per kg of body weight.

Claim 4

Dependent Claim 27 words

A method as in claim 2, wherein the total amount of TFPI polypeptide is delivered over a period in the range from 0.1 minute to 360 minutes.

Claim 5

Independent Claim 66 words

A method for inhibiting restenosis in a recanalized blood vessel, said method comprising: advancing a distal end of a catheter to a target site within the recanalized blood vessel; and delivering through the distal end of the catheter into the blood vessel wall an amount of a TFPI polypeptide sufficient to inhibit the accumulation of thrombus at said target site without substantially decreasing systemic clotting activity.

Claim 6

Independent Claim 66 words

A method for inhibiting restenosis in a recanalized blood vessel, said method comprising: advancing a distal end of a catheter to a target site within the recanalized blood vessel; and delivering through the distal end of the catheter into the blood vessel wall an amount of a TFPI polypeptide sufficient to inhibit the accumulation of thrombus at said target site without substantially decreasing systemic clotting activity.

Claim 7

Dependent Claim 27 words

A method as in claim 4, wherein the distal end of the catheter is introduced percutaneously to a patient's vasculature and advanced transluminally to the target site.

Claim 8

Dependent Claim 29 words

A method as in claim 4, wherein the TFPI polypeptide is delivered from a proximal end of the catheter, through a lumen in the catheter, to the distal end.

Claim 9

Dependent Claim 37 words

A method as in claim 4, further comprising expanding the distal end of the catheter to engage a plurality of infusion ports against the blood vessel wall, wherein the TFPI polypeptide is delivered through said infusion ports.

Claim 10

Dependent Claim 25 words

A method as in claim 4, wherein the amount of the TFPI polypeptide is from 0.1 μg to 10 mg per kg of body weight.

Claim 11

Dependent Claim 27 words

A method as in claim 8, wherein the total amount of TFPI polypeptide is delivered over a period in the range from 0.1 minute to 360 minutes.

Claim 12

Independent Claim 90 words

A method for inhibiting abrupt closure and restenosis in a recanalized blood vessel, said method comprising: advancing the distal end of an infusion catheter to a target site within the recanalized blood vessel; expanding the distal end of the infusion catheter to engage infusion ports on the catheter against the luminal wall of the blood vessel; and delivering through the infusion ports into the blood vessel wall an amount of a TFPI polypeptide sufficient to inhibit the accumulation of thrombus at said target site without substantially decreasing systemic clotting activity.

Claim 13

Independent Claim 90 words

A method for inhibiting abrupt closure and restenosis in a recanalized blood vessel, said method comprising: advancing the distal end of an infusion catheter to a target site within the recanalized blood vessel; expanding the distal end of the infusion catheter to engage infusion ports on the catheter against the luminal wall of the blood vessel; and delivering through the infusion ports into the blood vessel wall an amount of a TFPI polypeptide sufficient to inhibit the accumulation of thrombus at said target site without substantially decreasing systemic clotting activity.

Claim 14

Dependent Claim 27 words

A method as in claim 10, wherein the distal end of the catheter is introduced percutaneously to a patient's vasculature and advanced transluminally to the target site.

Claim 15

Dependent Claim 33 words

A method as in claim 10, wherein the TFPI polypeptide is delivered from a proximal end of the catheter, through a lumen in the catheter, to the infusion ports at the distal end.

Claim 16

Dependent Claim 43 words

A method as in claim 10, wherein the expanding step comprises inflating the distal end of the infusion catheter having the infusion ports with a fluid carrying the TFPI polypeptide with an inflation pressure to release the TFPI-containing fluid through the infusion ports.

Claim 17

Dependent Claim 31 words

A method as in claim 10, wherein the expanding step comprises: positioning a balloon within the distal end of the infusion catheter; and inflating the balloon to a predetermined inflation pressure.

Claim 18

Dependent Claim 32 words

A method as in claim 14, wherein the delivering step comprises supplying fluid to the infusion ports at a predetermined infusion pressure, wherein the infusion pressure is independent of the inflation pressure.

Claim 19

Dependent Claim 25 words

A method as in claim 10, wherein the amount of the TFPI polypeptide is from 0.1 μg to 10 mg per kg of body weight.

Claim 20

Dependent Claim 27 words

A method as in claim 16, wherein the total amount of TFPI polypeptide is delivered over a period in the range from 0.1 minute to 360 minutes.

Claim 21

Independent Claim 69 words

A method for recanalizing a blood vessel, said method comprising: enlarging the blood vessel lumen at a target site; advancing the distal end of an infusion catheter to the target site; and delivering through the distal end of the infusion catheter into the blood vessel wall an amount of a TFPI polypeptide sufficient to inhibit the accumulation of thrombus at said target site without substantially decreasing systemic clotting activity.

Claim 22

Independent Claim 69 words

A method for recanalizing a blood vessel, said method comprising: enlarging the blood vessel lumen at a target site; advancing the distal end of an infusion catheter to the target site; and delivering through the distal end of the infusion catheter into the blood vessel wall an amount of a TFPI polypeptide sufficient to inhibit the accumulation of thrombus at said target site without substantially decreasing systemic clotting activity.

Claim 23

Dependent Claim 27 words

A method as in claim 18, wherein the distal end of the catheter is introduced percutaneously to a patient's vasculature and advanced transluminally to the target site.

Claim 24

Dependent Claim 29 words

A method as in claim 18, wherein the TFPI polypeptide is delivered from a proximal end of the catheter, through a lumen in the catheter, to the distal end.

Claim 25

Dependent Claim 37 words

A method as in claim 18, further comprising expanding the distal end of the catheter to engage a plurality of infusion ports against the blood vessel wall, wherein the TFPI polypeptide is delivered through said infusion ports.

Claim 26

Dependent Claim 25 words

A method as in claim 18, wherein the amount of the TFPI polypeptide is from 0.1 μg to 10 mg per kg of body weight.

Claim 27

Dependent Claim 27 words

A method as in claim 22, wherein the total amount of TFPI polypeptide is delivered over a period in the range from 0.1 minute to 360 minutes.

Claim 28

Dependent Claim 19 words

A method as in claim 18, wherein the enlarging step comprises balloon angioplasty, atherectomy, laser recanalization, or stent placement.

Claim 29

Dependent Claim 43 words

A method as in claim 24, wherein the enlarging step comprises advancing an angioplasty balloon catheter to the treatment site, inflating a balloon at the distal end of the angioplasty balloon catheter to recanalize the blood vessel, and withdrawing the angioplasty balloon catheter.

Claim 30

Dependent Claim 27 words

A method as in claim 25, wherein the infusion catheter is advanced to the target site within one to ten minutes of withdrawing the angioplasty balloon catheter.

Claim 31

Dependent Claim 61 words

A method as in claim 25, further comprising placing the infusion catheter over the balloon angioplasty catheter after the withdrawal thereof, advancing the balloon angioplasty catheter together with the infusion catheter to the target site, and reinflating the balloon on the balloon angioplasty catheter to expand the distal end of the infusion catheter so that it contacts the blood vessel wall.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	2001-06-29	2001-12-29	2002-06-30	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2005-06-29	2005-12-29	2006-06-30	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2009-06-29	2009-12-29	2010-06-30	$7700.00	Window Closed / Lapsed

Localized intravascular delivery of TFPI for inhibition of restenosis in recanalized blood vessels

Abstract

Inventors

Bibliographic Details

Claims Analysis

References Cited (Backward Citations)

USPTO Annuity & Maintenance Windows

Assigned Categories & Tags

Assign Category Tag