US5276015A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of inhibiting microvascular thrombosis
Assignee: Washington University in St. Louis
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Filing: 1992-03-18
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Granted: 1994-01-04
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Expires: 2012-03-18
Abstract
Abstract A method for reducing the thrombogenicity of microvascular anastomoses in a warm blooded mammal comprising administering to said mammal at the site of said microvascular anastomoses contemporaneously with microvascular reconstruction of a small but inhibitory effective amount of TFPI.
Inventors
- 👤 Roger K. Khouri
- 👤 Tze-Chein Wun
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 00:18
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/55; A61K38/57; A61P; A61P7/00; A61P7/02
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
60 words
A method for reducing the thrombogenicity of microvascular anastomoses in a warm blooded mammal comprising administering topically to said mammal at the site of said microvascular anastomoses contemporaneously with microvascular reconstruction a small but inhibitory effective amount of from about 1 μg/ml to about 100 μg/ml applied in a volume of about 0.01 to about 1 ml volume of TFPI.
Claim 2
Independent Claim
60 words
A method for reducing the thrombogenicity of microvascular anastomoses in a warm blooded mammal comprising administering topically to said mammal at the site of said microvascular anastomoses contemporaneously with microvascular reconstruction a small but inhibitory effective amount of from about 1 μg/ml to about 100 μg/ml applied in a volume of about 0.01 to about 1 ml volume of TFPI.
Claim 3
Dependent Claim
16 words
The method of claim 1 in which the TFPI is carried in a normal saline vehicle.
Claim 4
Dependent Claim
27 words
The method of claim 2 in which the TFPI is carried in said vehicle at a dose that does not affect the peripheral blood PT and APTT.
Claim 5
Dependent Claim
18 words
The method of claim 1 in which the TFPI is administered during microvascular reconstruction by free flap transfer.
Claim 6
Dependent Claim
16 words
The method of claim 1 in which the TFPI is administered during microvascular reconstruction by replantation.
References Cited (Backward Citations)
US4966852A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-01-03 | 1997-07-05 | 1998-01-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-01-03 | 2001-07-05 | 2002-01-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-01-03 | 2005-07-05 | 2006-01-04 | $7700.00 | Window Closed / Lapsed |