US5106833A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Coagulation inhibitors
Assignee: Washington University in St. Louis
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Filing: 1989-01-26
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Granted: 1992-04-21
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Expires: 2009-01-26
Abstract
Abstract Novel blood coagulation inhibitors are disclosed which are peptide fragments comprising (A) Kunitz-type domain two of lipoprotein-associated coagulation inhibitor which inhibits Factor Xa production and (B) Kunitz-type domains one and two of lipoprotein-associated coagulation inhibitor which inhibits Factor VIIa/TF enzymatic complex formation.
Inventors
- 👤 George J. Broze, Jr.
- 👤 Thomas J. Girard
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 18:12
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/81; C07K14/8107; C07K14/811; C07K14/8114; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
62 words
A novel blood coagulation inhibitor selected from the group consisting of (A) a peptide fragment of lipoprotein-associated coagulation inhibitor having the sequence of residues 90 to 160 of the 276 residue mature LACI protein, and (B) a peptide fragment of lipoprotein-associated coagulation inhibitor having the sequence of residues 19 to 160 or 1 to 160 of the 276 residue mature LACI protein.
Claim 2
Dependent Claim
62 words
A novel blood coagulation inhibitor selected from the group consisting of (A) a peptide fragment of lipoprotein-associated coagulation inhibitor having the sequence of residues 90 to 160 of the 276 residue mature LACI protein, and (B) a peptide fragment of lipoprotein-associated coagulation inhibitor having the sequence of residues 19 to 160 or 1 to 160 of the 276 residue mature LACI protein.
Claim 3
Independent Claim
41 words
A method of inhibiting Factor Xa production in a mammal comprising administering to said mammal an effective amount of a peptide fragment of lipoprotein-associated coagulation inhibitor having the sequence of residues 90 to 160 of the 276 residue mature LACI protein.
Claim 4
Independent Claim
41 words
A method of inhibiting Factor Xa production in a mammal comprising administering to said mammal an effective amount of a peptide fragment of lipoprotein-associated coagulation inhibitor having the sequence of residues 90 to 160 of the 276 residue mature LACI protein.
Claim 5
Independent Claim
47 words
A method of inhibiting Factor VIIa/TF enzymatic complex formation in a mammal comprising administering to said mammal an effective amount of a peptide fragment of lipoprotein-associated coagulation inhibitor having the sequence of residues 19 to 160 or 1 to 160 of the 276 residue mature LACI protein.
Claim 6
Independent Claim
47 words
A method of inhibiting Factor VIIa/TF enzymatic complex formation in a mammal comprising administering to said mammal an effective amount of a peptide fragment of lipoprotein-associated coagulation inhibitor having the sequence of residues 19 to 160 or 1 to 160 of the 276 residue mature LACI protein.
References Cited (Backward Citations)
US4966852A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-04-21 | 1995-10-21 | 1996-04-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-04-21 | 1999-10-21 | 2000-04-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-04-21 | 2003-10-21 | 2004-04-21 | $7700.00 | Window Closed / Lapsed |