US6432436B1
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US
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Partially demineralized cortical bone constructs
Assignee: Musculoskeletal Transplant Foundation
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Filing: 2000-12-19
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Granted: 2002-08-13
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Expires: 2020-12-19
Abstract
Abstract The invention is directed toward a sterile bone structure for application to a bone defect site to promote new bone growth at the site comprising a partially demineralized cortical bone structure, said bone structure comprising a cross sectional surface are ranging from 85% to 95% of the original bone surface area before demineralization with the remaining partially demineralized cortical bone structure having an outer demineralized layer ranging in thickness from about 0.05 mm to about 0.14 mm and a mineralized core.
Inventors
- 👤 Arthur A. Gertzman
- 👤 Moon Hae Sunwoo
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 04:02
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/38; A61L27/3839; A61L27/3843; A61L27/3847; A61F; A61F2/00; A61F2/02; A61F2/28; A61L27/3604; A61L27/3608; A61L27/3641; A61L27/3645; A61L27/365; A61L27/3683; A61L27/3691; A61L31/00; A61L31/005; A61B; A61B17/00; A61B17/56; A61B17/58; A61B17/68; A61B17/84; A61B17/86; A61F2/30; A61F2/3094; A61F2/44; A61F2/4455; A61F2/446; A61F2/447; A61F2002/2817; A61F2002/2835; A61F2002/2839; A61F2002/30001; A61F2002/30003; A61F2002/30004; A61F2002/30059; A61F2002/30108; A61F2002/30199; A61F2002/302; A61F2002/30224; A61F2002/3023; A61F2/30767; A61F2/30771; A61F2002/30841; A61F2002/30843; A61F2002/30878; A61F2002/30891; A61F2002/30892; A61F2002/30894; A61F2230/00; A61F2230/0063; A61F2230/0065; A61F2230/0069; A61F2310/00; A61F2310/00005; A61F2310/00179; A61F2310/00293; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
93 words
A sterile bone structure for application to a bone defect site to promote new bone growth at the site comprising a single allograft bone body with an outer partially demineralized cortical bone section and a central mineral bone core section, said bone structure after the demineralization process retaining a cross sectional surface area ranging from about 85% to about 95% of the original mineralized bone surface area before demineralization with the remaining partially demineralized cortical bone structure comprising an outer demineralized layer ranging from about 0.05 mm to about 0.08 mm in thickness.
Claim 2
Dependent Claim
93 words
A sterile bone structure for application to a bone defect site to promote new bone growth at the site comprising a single allograft bone body with an outer partially demineralized cortical bone section and a central mineral bone core section, said bone structure after the demineralization process retaining a cross sectional surface area ranging from about 85% to about 95% of the original mineralized bone surface area before demineralization with the remaining partially demineralized cortical bone structure comprising an outer demineralized layer ranging from about 0.05 mm to about 0.08 mm in thickness.
Claim 3
Dependent Claim
27 words
A sterile bone structure as claimed in claim 1 wherein said bone structure includes bone morphogenic proteins in excess of the amount naturally occurring in allogenic bone.
Claim 4
Dependent Claim
15 words
A sterile bone structure as claimed in claim 1 wherein said structure is a pin.
Claim 5
Dependent Claim
15 words
A sterile bone structure as claimed in claim 1 wherein said structure is a plate.
Claim 6
Dependent Claim
15 words
A sterile bone structure as claimed in claim 1 wherein said structure is a screw.
Claim 7
Dependent Claim
15 words
A sterile bone structure as claimed in claim 1 wherein said structure is a rod.
Claim 8
Dependent Claim
15 words
A sterile bone structure as claimed in claim 1 wherein said structure is a wedge.
Claim 9
Dependent Claim
15 words
A sterile bone structure as claimed in claim 1 wherein said structure is a rod.
Claim 10
Dependent Claim
15 words
A sterile bone structure as claimed in claim 1 wherein said structure is an anchor.
Claim 11
Dependent Claim
16 words
A sterile bone structure as claimed in claim 1 wherein said structure is a fusion ring.
Claim 12
Dependent Claim
16 words
A sterile bone structure as claimed in claim 1 wherein said structure is a fusion block.
Claim 13
Dependent Claim
47 words
A sterile malleable bone composition as claimed in claim 1 including antimicrobial and/or antibiotics selected from the group consisting of erythromycin, bacitracin, neomycin, penicillin, polymyxin B, tetracycline, viomycin, chloromycetin and streptomycin, cefazolin, ampicillin, azactam, tobramycin, clindamycin and gentamycin added to the demineralized layer of said bone structure.
Claim 14
Dependent Claim
23 words
A sterile bone structure as claimed in claim 1 including a soluble silver compound added to said demineralized layer of said bone structure.
Claim 15
Dependent Claim
26 words
A sterile bone structure as claimed in claim 13 wherein said soluble silver compound contains silver in a range of 10 to 10,000 parts per million.
Claim 16
Dependent Claim
37 words
A sterile bone structure as claimed in claim 13 wherein said silver compound is taken from a group consisting of silver nitrate, silver chloride, silver oxide, silver sulphate, silver phosphate, silver acetate, silver perchlorate, or silver tartrate.
Claim 17
Dependent Claim
92 words
A sterile bone structure for application to a bone defect site to promote new bone growth at the site comprising a partially demineralized cortical bone structure with a central mineral bone section, said bone structure after the demineralization process retaining a cross sectional surface area ranging from about 85% to about 95% of the original mineralized bone surface area before demineralization with the remaining partially demineralized cortical bone structure comprising an outer demineralized portion ranging from about 5% to about 15% of the cross sectional area of the demineralized cortical bone structure.
Claim 18
Dependent Claim
92 words
A sterile bone structure for application to a bone defect site to promote new bone growth at the site comprising a partially demineralized cortical bone structure with a central mineral bone section, said bone structure after the demineralization process retaining a cross sectional surface area ranging from about 85% to about 95% of the original mineralized bone surface area before demineralization with the remaining partially demineralized cortical bone structure comprising an outer demineralized portion ranging from about 5% to about 15% of the cross sectional area of the demineralized cortical bone structure.
Claim 19
Dependent Claim
69 words
A sterile partially demineralized bone structure for application to a bone defect site to promote new bone growth at the site comprising a partially demineralized single piece cortical bone structure with a thickness in excess of 2 mm, said cortical bone structure being provided with an outer surface layer of demineralized bone having a thickness ranging from about 0.05 mm to about 0.11 mm and a central mineralized section.
Claim 20
Dependent Claim
69 words
A sterile partially demineralized bone structure for application to a bone defect site to promote new bone growth at the site comprising a partially demineralized single piece cortical bone structure with a thickness in excess of 2 mm, said cortical bone structure being provided with an outer surface layer of demineralized bone having a thickness ranging from about 0.05 mm to about 0.11 mm and a central mineralized section.
Claim 21
Dependent Claim
84 words
A sterile partially demineralized bone structure for application to a bone defect site to promote new bone growth at the site comprising a single piece partially demineralized cortical bone structure with a thickness in excess of 2 mm, said bone structure having an outer surface layer of demineralized bone with a thickness ranging from about 0.14 mm to about 0.17 mm and a central mineralized section having a cross sectional area of at least 2 times the cross sectional area of said demineralized layer.
Claim 22
Dependent Claim
84 words
A sterile partially demineralized bone structure for application to a bone defect site to promote new bone growth at the site comprising a single piece partially demineralized cortical bone structure with a thickness in excess of 2 mm, said bone structure having an outer surface layer of demineralized bone with a thickness ranging from about 0.14 mm to about 0.17 mm and a central mineralized section having a cross sectional area of at least 2 times the cross sectional area of said demineralized layer.
Claim 23
Dependent Claim
86 words
A sterile partially demineralized bone structure for application to a bone defect site to promote new bone growth at the site comprising a unitary cortical formed bone device with a partially demineralized cortical bone structure with a thickness in excess of 2 mm having an outer surface layer of demineralized bone having a thickness ranging from about 0.08 mm to about 0.11 mm and a central mineralized section having a cross sectional area of at least 3 times the cross sectional area of said demineralized layer.
Claim 24
Dependent Claim
86 words
A sterile partially demineralized bone structure for application to a bone defect site to promote new bone growth at the site comprising a unitary cortical formed bone device with a partially demineralized cortical bone structure with a thickness in excess of 2 mm having an outer surface layer of demineralized bone having a thickness ranging from about 0.08 mm to about 0.11 mm and a central mineralized section having a cross sectional area of at least 3 times the cross sectional area of said demineralized layer.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2005-08-12 | 2006-02-11 | 2006-08-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2009-08-12 | 2010-02-11 | 2010-08-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2013-08-12 | 2014-02-11 | 2014-08-13 | $7700.00 | Window Closed / Lapsed |