US6387124B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Biodegradable drug delivery vascular stent
Assignee: Boston Scientific Scimed Inc
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Filing: 1999-10-18
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Granted: 2002-05-14
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Expires: 2019-10-18
Abstract
Abstract A stent includes a main body of a generally tubular shape for insertion into a lumen of a vessel of a living being. The tubular main body includes a substantially biodegradable matrix having collagen IV and laminin that enclose voids within the matrix. The tubular main body also includes a biodegradable strengthening material in contact with the matrix to strengthen the matrix. The tubular main body is essentially saturated with drugs.
Inventors
- 👤 Paul J. Buscemi
- 👤 Elizabeth A. Stejskal
- 👤 II Donald F. Palme
- 👤 Lixiao Wang
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:33
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/82; A61F2/86; A61F2/88; A61L; A61L31/00; A61L31/04; A61L31/041; A61L31/043; A61L31/044; A61L31/047; A61L31/14; A61L31/148; A61L31/16; A61F2/95; A61F2/958; A61F2210/00; A61F2210/0004; A61F2210/0014; A61F2210/0023; A61F2250/00; A61F2250/0058; A61F2250/0067; A61F2250/0068; A61L2300/00; A61L2300/40; A61L2300/42; A61L2300/60; A61L2300/602; A61L2300/604; A61L2300/606; A61L2300/62; A61L2300/622; Y; Y10; Y10S; Y10S623/00; Y10S623/901
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
65 words
A stent having a generally tubular main body for insertion into a lumen of a vessel of a living being wherein the tubular main body comprises a substantially biodegradable matrix that includes collagen IV and laminin that enclose voids within the matrix, and a biodegradable strengthening material in contact with the matrix to strengthen the matrix, the tubular main body being essentially saturated with drugs.
Claim 2
Dependent Claim
65 words
A stent having a generally tubular main body for insertion into a lumen of a vessel of a living being wherein the tubular main body comprises a substantially biodegradable matrix that includes collagen IV and laminin that enclose voids within the matrix, and a biodegradable strengthening material in contact with the matrix to strengthen the matrix, the tubular main body being essentially saturated with drugs.
Claim 3
Dependent Claim
13 words
The stent of claim 1 wherein the biodegradable strengthening material includes polylactic acid.
Claim 4
Dependent Claim
16 words
The stent of claim 1 wherein the strengthening material includes particles dispersed within the biodegradable matrix.
Claim 5
Dependent Claim
16 words
The stent of claim 1 wherein the strengthening material includes a layer attached to the matrix.
Claim 6
Dependent Claim
14 words
The stent of claim 1 wherein the drugs are included in the biodegradable matrix.
Claim 7
Dependent Claim
17 words
The stent of claim 1 wherein the drugs are included in the voids within the biodegradable matrix.
Claim 8
Dependent Claim
15 words
The stent of claim 1 wherein the drugs are included within the biodegradable strengthening material.
Claim 9
Dependent Claim
11 words
The stent of claim 1 wherein the drugs include microencapsulated drugs.
Claim 10
Dependent Claim
13 words
The stent of claim 1 wherein the biodegradable matrix further includes a glycosaminoglucuronan.
Claim 11
Dependent Claim
10 words
The stent of claim 9 wherein the glycosaminoglucuronan includes heparin.
Claim 12
Dependent Claim
68 words
The stent of claim 1 further having an exterior surface for contacting the vessel when the main body is placed in a living being, a cambered interior surface contacting a fluid passing through the lumen of the vessel, a leading end facing a direction of flow and a trailing end wherein the main body has substantially the same thickness at the leading end as at the trailing end.
Claim 13
Dependent Claim
17 words
The stent of claim 11 and further including a water soluble coating that overlays the interior surface.
Claim 14
Dependent Claim
14 words
The stent of claim 1 wherein the tubular main body is a coiled strip.
Claim 15
Dependent Claim
27 words
The stent of claim 13 wherein the coiled strip includes a meltable firm coating that melts upon application of the energy and that overlays the interior surface.
Claim 16
Dependent Claim
37 words
The stent of claim 1 wherein the biodegradable strengthening material is treated by an application of energy of a magnitude ineffective to cause bonding with living tissue of the lumen while the stent is in the lumen.
Claim 17
Dependent Claim
28 words
The stent of claim 15 wherein the energy causes an increase in temperature of the biodegradable strengthening material above a glass transition temperature of the biodegradable strengthening material.
Claim 18
Dependent Claim
30 words
The stent of claim 15 wherein the biodegradable strengthening material is treated by application of mechanical energy of a magnitude less than an elastic limit of the biodegradable strengthening material.
Claim 19
Dependent Claim
52 words
The stent of claim 15 further including a plurality of microcapsules within the biodegradable strengthening material, the microcapsules containing a material inducing crosslinking of the biodegradable strengthening material wherein the application of energy causes a rupture of the microcapsules and a releasing of the material inducing crosslinking of the biodegradable strengthening material.
Claim 20
Independent Claim
132 words
A method for positioning a stent having a tubular main body made of a substantially biodegradable matrix that includes collagen IV and laminin that enclose voids within the matrix, and a biodegradable strengthening material in contact with the matrix to strengthen the matrix, the method comprising: positioning the tubular main body having a first diameter around a balloon of a catheter; moving the balloon and the tubular main body to a site within a lumen of a vessel of a living being; expanding the tubular main body by an expansion of the balloon to increase the first diameter of the tubular main body to a second diameter; applying energy to the tubular main body to harden the biodegradable strengthening material; cooling the tubular main body; and releasing the stent from the balloon.
Claim 21
Independent Claim
132 words
A method for positioning a stent having a tubular main body made of a substantially biodegradable matrix that includes collagen IV and laminin that enclose voids within the matrix, and a biodegradable strengthening material in contact with the matrix to strengthen the matrix, the method comprising: positioning the tubular main body having a first diameter around a balloon of a catheter; moving the balloon and the tubular main body to a site within a lumen of a vessel of a living being; expanding the tubular main body by an expansion of the balloon to increase the first diameter of the tubular main body to a second diameter; applying energy to the tubular main body to harden the biodegradable strengthening material; cooling the tubular main body; and releasing the stent from the balloon.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2005-05-13 | 2005-11-12 | 2006-05-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2009-05-13 | 2009-11-12 | 2010-05-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2013-05-13 | 2013-11-12 | 2014-05-14 | $7700.00 | Window Closed / Lapsed |