EP0420541A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Biodegradable stent
Assignee: Bristol Myers Squibb Co
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Filing: 1990-09-24
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Granted: —
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Expires: 2010-09-24
Abstract
Abstract A biodegradable, biocompatible, resorbable ureteral stent made of a biodegradable polymer composition and having a tensile strength of at least about 500 psi, an elongation greater than about 10% and a Shore A hardness of about 50 to 100. The polymer composition preferably comprises a terpolymer of L(-)lactide, glycolide and epsilon-caprolactone and the speed of resorption of the stent can be controlled by varying the molecular weight. This invention includes a method for treating ureteral obstructions or impairments by utilizing a biodegradable, biocompatible, resorbable infusion stent.
Inventors
- 👤 Jay R. Goldberg
- 👤 Richard G. Sinclair
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 00:57
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/82; A61F2/94; A61L; A61L31/00; A61L31/04; A61L31/06; A61L31/14; A61L31/148; A61B; A61B90/00; A61B90/39; A61F2/02; A61F2/04; A61F2002/048; A61F2210/00; A61F2210/0004; A61F2250/00; A61F2250/0058; A61F2250/0096; A61F2250/0098
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
57 words
An article of manufacture comprising a biocompatible, resorbable ureteral stent made of a biodegradable polymeric composition, wherein said stent is used for treating ureteral obstruction and has the following properties: (i) a tensile strength of at least about 500 psi, (ii) an elongation greater than about 10%, and (iii) Shore A hardness of about 50 to 100.
Claim 2
Dependent Claim
57 words
An article of manufacture comprising a biocompatible, resorbable ureteral stent made of a biodegradable polymeric composition, wherein said stent is used for treating ureteral obstruction and has the following properties: (i) a tensile strength of at least about 500 psi, (ii) an elongation greater than about 10%, and (iii) Shore A hardness of about 50 to 100.
Claim 3
Dependent Claim
21 words
The stent of claim 1, wherein the weight average molecular weight of said polymeric composition varies from about 50,000 to 400,000.
Claim 4
Dependent Claim
28 words
The stent of claim 1 or claim 2, having a minimum curl strength of at least about 4 grams and a minimum break strength of about 1.7 pounds.
Claim 5
Dependent Claim
49 words
A biodegradable, biocompatible, resorbable, ureteral stent comprising a terpolymer of: (a) L(-)lactide (b) glycolide, and (c) epsilon-caprolactone, wherein said ureteral stent has: (i) a tensile strength of at least about 500 psi, (ii) an elongation greater than about 10%, and (iii) Shore A hardness of about 50 to 100.
Claim 6
Dependent Claim
49 words
A biodegradable, biocompatible, resorbable, ureteral stent comprising a terpolymer of: (a) L(-)lactide (b) glycolide, and (c) epsilon-caprolactone, wherein said ureteral stent has: (i) a tensile strength of at least about 500 psi, (ii) an elongation greater than about 10%, and (iii) Shore A hardness of about 50 to 100.
Claim 7
Dependent Claim
17 words
The ureteral stent of claim 4 wherein the epsilon-caprolactone varies from about 15 to 25 weight %.
Claim 8
Dependent Claim
20 words
The ureteral stent of claim 4 or claim 5 wherein the L(-)lactide varies from about 45 to 85 weight %.
Claim 9
Dependent Claim
22 words
The ureteral stent of claim 4, claim 5 or claim 6, wherein the glycolide varies from about 5 to 50 weight %.
Claim 10
Dependent Claim
21 words
The ureteral stent of any one of claims 1 to 7, wherein the modulus varies from about 6000 to 7000 psi.
Claim 11
Dependent Claim
20 words
The ureteral stent of any one of claims 4 to 18, bendable into a pliable curl set at each end,
Claim 12
Dependent Claim
19 words
The ureteral stent of any one of claims 4 to 9, sterilizable and capable of compounding with radiopaque materials.
Claim 13
Dependent Claim
23 words
The ureteral stent of any one of claims 4 to 10, also including about 5 to 30 weight % of a radiopaque material.
Claim 14
Dependent Claim
15 words
The ureteral stent of claim 11, wherein said radiopaque material is finely divided barium sulfate.
Claim 15
Dependent Claim
14 words
The ureteral stent of any one of claims 4 to 12, in transparent form.
Claim 16
Dependent Claim
26 words
The ureteral stent of any one of claims 4 to 13, wherein the terpolymer has a weight average molecular weight varying from about 20,000 to 1,000,000.
Claim 17
Dependent Claim
25 words
The ureteral stent of any one of claims 4 to 13, wherein the terpolymer has a weight average molecular weight of about 50,000 to 400,000
Claim 18
Dependent Claim
29 words
The ureteral stent of any one of claims 4 to 15, wherein the terpolymer has a melt process decomposition temperature greater than or equal to about 230 o C.
Claim 19
Dependent Claim
29 words
The ureteral stent of any one of claims 4 to 16, wherein the terpolymer has a tube extrusion processing temperature that varies from about 135 to 150 o C.
Claim 20
Independent Claim
59 words
A method for treating ureteral obstruction or impairment in a mammalian host by implanting therein a biodegradable, biocompatible resorbable stent between the kidney and the bladder, said stent having the following properties: (i) a tensile strength of at least about 500 psi, (ii) an elongation greater than about 10%, and (iii) Shore A hardness of about 50 to 100.
Claim 21
Independent Claim
59 words
A method for treating ureteral obstruction or impairment in a mammalian host by implanting therein a biodegradable, biocompatible resorbable stent between the kidney and the bladder, said stent having the following properties: (i) a tensile strength of at least about 500 psi, (ii) an elongation greater than about 10%, and (iii) Shore A hardness of about 50 to 100.
Claim 22
Dependent Claim
19 words
The method of claim 18, wherein the stent is as claimed in any one of claims 1 to 17.
Claim 23
Dependent Claim
37 words
The method of claim 18 or claim 19, wherein the stent has the following properties: (a) tensile strength greater than 1000 psi, (b) elongation greater than 100%, and (c) Shore A hardness of about 75 to 95.
Claim 24
Independent Claim
111 words
A method for controlling the time of biodegradation in mammalian body tissue of a biodegradable, biocompatible, resorbable ureteral stent, by implanting a polymeric stent in mammalian body tissues wherein said polymeric stent is biodegradable, biocompatible and resorbable and has the following properties: (a) a tensile strength of at least about 500 psi, (b) an elongation greater than about 10%, and (c) Shore A hardness of about 50 to 100, and controlling the rate of biodegradation of said polymeric stent from a few weeks to a few months, by varying the molecular weight of the polymer composition comprising the stent, from a weight average molecular weight of about 50,000 to about 1,000,000.
Claim 25
Independent Claim
111 words
A method for controlling the time of biodegradation in mammalian body tissue of a biodegradable, biocompatible, resorbable ureteral stent, by implanting a polymeric stent in mammalian body tissues wherein said polymeric stent is biodegradable, biocompatible and resorbable and has the following properties: (a) a tensile strength of at least about 500 psi, (b) an elongation greater than about 10%, and (c) Shore A hardness of about 50 to 100, and controlling the rate of biodegradation of said polymeric stent from a few weeks to a few months, by varying the molecular weight of the polymer composition comprising the stent, from a weight average molecular weight of about 50,000 to about 1,000,000.
Claim 26
Dependent Claim
21 words
The method of claim 21, wherein the weight average molecular weight of said polymeric stent varies from about 50,000 to 400,000.
References Cited (Backward Citations)
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