US6251129B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for low temperature thrombolysis and low temperature thrombolytic agent with selective organ temperature control
Assignee: Zoll Circulation Inc
•
Filing: 1998-12-16
•
Granted: 2001-06-26
•
Expires: 2018-12-16
Abstract
Abstract The invention provides a method for substantially reducing the size of a thrombus in a blood vessel in which blood is flowing. The method includes delivering a heat transfer element to a blood vessel in fluid communication with a thrombosed blood vessel. The temperature of the heat transfer element is adjusted such that the same is sufficient to remove heat from the flowing blood. Heat is transferred from a volume including the thrombus to the heat transfer element. In a separate embodiment, heat may be delivered to the volume including the thrombus from the heat transfer element. The resultant temperature of the volume may be sufficient to substantially reduce the size of a thrombus. For example, the resultant temperature of the volume may be sufficiently high to substantially enhance plasminogen activation near the thrombus. In a separate embodiment, a therapeutic drug may be delivered to the blood vessel to further reduce the size of a thrombus, the drug having an optimal temperature at the hypothermic or hyperthernic temperature of the blood.
Inventors
- 👤 John D. Dobak, III
- 👤 Juan C. Lasheras
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 22:34
CPC Classifications
A; A61; A61F; A61F7/00; A61F7/12; A61B; A61B18/00; A61B18/02; A61M; A61M25/00; A61B17/00; A61B17/00234; A61B2017/00292; A61B2018/00053; A61B2018/00214; A61B2018/0022; A61B2018/0212; A61B2018/0231; A61B2018/0262; A61B2018/0268; A61B2018/0281; A61F2007/0054; A61F2007/0056; A61F2007/126; A61M2025/0004; A61M25/0043; A61M2025/006; A61M2205/00; A61M2205/36; A61M2205/3606; A61M25/0021; A61M25/0023
Claims Analysis
Total Claims: 37
Claim 1
Independent Claim
95 words
A method for substantially reducing the size of a thrombus in a blood vessel in which blood is flowing, comprising: delivering a heat transfer element to a blood vessel in fluid communication with a thrombosed blood vessel; adjusting the temperature of the heat transfer element such that the temperature of the heat transfer element is sufficient to remove heat from the flowing blood; and transferring heat from a volume including the thrombus to the heat transfer element, such that the resultant temperature of the volume is sufficient to substantially reduce the size of a thrombus.
Claim 2
Independent Claim
95 words
A method for substantially reducing the size of a thrombus in a blood vessel in which blood is flowing, comprising: delivering a heat transfer element to a blood vessel in fluid communication with a thrombosed blood vessel; adjusting the temperature of the heat transfer element such that the temperature of the heat transfer element is sufficient to remove heat from the flowing blood; and transferring heat from a volume including the thrombus to the heat transfer element, such that the resultant temperature of the volume is sufficient to substantially reduce the size of a thrombus.
Claim 3
Dependent Claim
27 words
The method of claim 1 , wherein the temperature of the heat transfer element is adjusted to a temperature of between about 30° C. and 32° C.
Claim 4
Dependent Claim
29 words
The method of claim 1 , wherein the temperature sufficient to substantially reduce the size of a thrombus is sufficient to substantially reduce plasmin inhibitor activity near the thrombus.
Claim 5
Dependent Claim
37 words
The method of claim 1 , further comprising raising the temperature of the heat transfer element from a temperature sufficient to substantially reduce the size of the thrombus to a temperature sufficient to substantially rewarm the volume.
Claim 6
Dependent Claim
37 words
The method of claim 4 , further comprising cycling the temperature of the heat transfer element between a temperature sufficient to substantially reduce the size of the thrombus and a temperature sufficient to substantially rewarm the volume.
Claim 7
Dependent Claim
42 words
The method of claim 5 , wherein the temperature sufficient to reduce the size of the thrombus is between about 25° C. and 32° C. and the temperature sufficient to substantially rewarm the volume is between about 34° C. and 36° C.
Claim 8
Dependent Claim
14 words
The method of claim 1 , further comprising inducing turbulence in the flowing blood.
Claim 9
Dependent Claim
20 words
The method of claim 7 , wherein the inducing induces turbulence with a turbulence intensity of greater than about 0.05.
Claim 10
Dependent Claim
26 words
The method of claim 7 , further comprising inducing blood turbulence in greater than 20% of a period of a cardiac cycle within a carotid artery.
Claim 11
Dependent Claim
22 words
The method of claim 9 , further comprising inducing blood turbulence throughout a period of a cardiac cycle within a carotid artery.
Claim 12
Dependent Claim
37 words
The method of claim 1 , wherein the delivering and adjusting further comprise: inserting the heat transfer element into the vessel; and cooling the heat transfer element by delivering a working fluid to the heat transfer element.
Claim 13
Dependent Claim
23 words
The method of claim 11 , further comprising delivering the working fluid at a temperature of between about −3° C. and 1° C.
Claim 14
Dependent Claim
21 words
The method of claim 11 , further comprising delivering the working fluid at a pressure of less than about 5 atmospheres.
Claim 15
Dependent Claim
22 words
The method of claim 13 , further comprising delivering the working fluid at a pressure of between about 1 and 5 atmospheres.
Claim 16
Dependent Claim
14 words
The method of claim 11 , further comprising inducing turbulence in the working fluid.
Claim 17
Dependent Claim
17 words
The method of claim 1 , further comprising inflating the heat transfer element with a working fluid.
Claim 18
Dependent Claim
20 words
The method of claim 16 , wherein the inflating further comprises passing the working fluid through a substantially helical-shaped structure.
Claim 19
Dependent Claim
20 words
The method of claim 1 , further comprising absorbing between about 75 and 200 watts of heat from the blood.
Claim 20
Independent Claim
57 words
A method for selective thrombolysis by selective vessel hypothermia, comprising: introducing a catheter having a heat transfer element into a thrombosed blood vessel; cooling the heat transfer element; and inducing free stream turbulence in blood flowing over the heat transfer element; such that heat is removed from the blood to cool the blood within the thrombosed vessel.
Claim 21
Independent Claim
57 words
A method for selective thrombolysis by selective vessel hypothermia, comprising: introducing a catheter having a heat transfer element into a thrombosed blood vessel; cooling the heat transfer element; and inducing free stream turbulence in blood flowing over the heat transfer element; such that heat is removed from the blood to cool the blood within the thrombosed vessel.
Claim 22
Independent Claim
96 words
A method for selective thrombolysis by selective vessel hypothermia, comprising: introducing a catheter having a heat transfer element into a blood vessel in fluid communication with a thrombosed blood vessel; cooling the heat transfer element by flowing a working fluid through the heat transfer element; cooling the blood by flowing the blood past the heat transfer element and inducing free stream turbulence in the blood, such that the blood is cooled to a prespecified temperature range; and delivering a thrombolytic drug to the blood, the thrombolytic drug having a working temperature within the prespecified temperature range.
Claim 23
Independent Claim
96 words
A method for selective thrombolysis by selective vessel hypothermia, comprising: introducing a catheter having a heat transfer element into a blood vessel in fluid communication with a thrombosed blood vessel; cooling the heat transfer element by flowing a working fluid through the heat transfer element; cooling the blood by flowing the blood past the heat transfer element and inducing free stream turbulence in the blood, such that the blood is cooled to a prespecified temperature range; and delivering a thrombolytic drug to the blood, the thrombolytic drug having a working temperature within the prespecified temperature range.
Claim 24
Dependent Claim
25 words
The method of claim 20 , wherein the drug is chosen from the group consisting of tPA, urokinase, streptokinase, precursors of urokinase, and combinations thereof.
Claim 25
Dependent Claim
24 words
The method of claim 20 , wherein the drug is tPA and the prespecified temperature range is between about 30° C. to 32° C.
Claim 26
Independent Claim
92 words
A method for selective thrombolysis by selective vessel hypothermia, comprising: introducing a catheter having a heat transfer element into a thrombosed blood vessel; cooling the heat transfer element by flowing a working fluid through the heat transfer element; cooling the blood by flowing the blood past the heat transfer element and inducing free stream turbulence in the blood, such that the blood is cooled to a prespecified temperature range; delivering a thrombolytic drug to the blood, the thrombolytic drug having a working temperature within the prespecified temperature range; and rewarming the blood.
Claim 27
Independent Claim
92 words
A method for selective thrombolysis by selective vessel hypothermia, comprising: introducing a catheter having a heat transfer element into a thrombosed blood vessel; cooling the heat transfer element by flowing a working fluid through the heat transfer element; cooling the blood by flowing the blood past the heat transfer element and inducing free stream turbulence in the blood, such that the blood is cooled to a prespecified temperature range; delivering a thrombolytic drug to the blood, the thrombolytic drug having a working temperature within the prespecified temperature range; and rewarming the blood.
Claim 28
Dependent Claim
25 words
The method of claim 23 , wherein the drug is chosen from the group consisting of tPA, urokinase, streptokinase, precursors of urokinase, and combinations thereof.
Claim 29
Dependent Claim
35 words
The method of claim 24 , wherein the thrombolytic drug is streptokinase, the prespecified temperature range is between about 30° C. and 32° C., and the rewarming raises the blood temperature to about 37° C.
Claim 30
Dependent Claim
32 words
The method of claim 24 , wherein the thrombolytic drug is urokinase, the prespecified temperature range is below about 28° C., and the rewarming raises the blood temperature to about 37° C.
Claim 31
Dependent Claim
35 words
The method of claim 24 , wherein the thrombolytic drug is a precursor to urokinase, the prespecified temperature range is below about 28° C., and the rewarming raises the blood temperature to about 37° C.
Claim 32
Independent Claim
80 words
A method for selective thrombolysis by selective vessel hyperthermia, comprising: introducing a catheter having a heat transfer element into a thrombosed blood vessel; heating the heat transfer element by flowing a working fluid through the heat transfer element; heating the blood by flowing the blood past the heat transfer element, such that the blood is heated to a prespecified temperature range; and delivering a thrombolytic drug to the blood, the thrombolytic drug a working temperature within the prespecified temperature range.
Claim 33
Independent Claim
80 words
A method for selective thrombolysis by selective vessel hyperthermia, comprising: introducing a catheter having a heat transfer element into a thrombosed blood vessel; heating the heat transfer element by flowing a working fluid through the heat transfer element; heating the blood by flowing the blood past the heat transfer element, such that the blood is heated to a prespecified temperature range; and delivering a thrombolytic drug to the blood, the thrombolytic drug a working temperature within the prespecified temperature range.
Claim 34
Dependent Claim
25 words
The method of claim 28 , wherein the drug is chosen from the group consisting of tPA, urokinase, streptokinase, precursors of urokinase, and combinations thereof.
Claim 35
Dependent Claim
24 words
The method of claim 29 , wherein the drug is tPA and the prespecified temperature range is between about 37° C. to 40° C.
Claim 36
Independent Claim
84 words
A method for eliminating a thrombus in a blood vessel in which blood is flowing, comprising: delivering a heat transfer element to the blood vessel; adjusting the temperature of the heat transfer element such that the temperature of the heat transfer element is sufficient to supply heat to the flowing blood; and transferring heat from the heat transfer element to a volume including the thrombus, such that the resultant temperature of the volume is sufficiently high to substantially enhance plasminogen activation near the thrombus.
Claim 37
Independent Claim
84 words
A method for eliminating a thrombus in a blood vessel in which blood is flowing, comprising: delivering a heat transfer element to the blood vessel; adjusting the temperature of the heat transfer element such that the temperature of the heat transfer element is sufficient to supply heat to the flowing blood; and transferring heat from the heat transfer element to a volume including the thrombus, such that the resultant temperature of the volume is sufficiently high to substantially enhance plasminogen activation near the thrombus.
References Cited (Backward Citations)
US2374609A
Cited
US2308484A
Cited
US2615686A
Cited
US2672032A
Cited
US2913009A
Cited
US3425419A
Cited
US3298371A
Cited
US3504674A
Cited
US3865116A
Cited
US3888259A
Cited
US4038519A
Cited
US3971383A
Cited
US4190033A
Cited
US4275734A
Cited
US4153048A
Cited
US4231425A
Cited
SU806029A1
Cited
FR2447406B1
Cited
US4318722A
Cited
US4298006A
Cited
US4427009A
Cited
US4445500A
Cited
US4569355A
Cited
US4502286A
Cited
US4483341A
Cited
US4581017A
Cited
US4581017B1
Cited
US4672962A
Cited
US5019075A
Cited
US4762129B1
Cited
US4762129A
Cited
US4748979A
Cited
US4655746A
Cited
US4920963A
Cited
US4750493A
Cited
US5002531A
Cited
US5018521A
Cited
US4894164A
Cited
US5358486A
Cited
US4820349A
Cited
US5106360A
Cited
US4860744A
Cited
US5041089A
Cited
US5423745A
Cited
US4904237A
Cited
US4883455A
Cited
US5147355A
Cited
US5014695A
Cited
US5151100A
Cited
US5191883A
Cited
US5368591A
Cited
US5108390A
Cited
US5078713A
Cited
US5110721A
Cited
US4964409A
Cited
US5344436A
Cited
US5257977A
Cited
US5310440A
Cited
US5902268A
Cited
US5624392A
Cited
US5092841A
Cited
US5196024A
Cited
US5190539A
Cited
US5417686A
Cited
US5591162A
Cited
US5584804A
Cited
US5149321A
Cited
US5234405A
Cited
US5395314A
Cited
US5827222A
Cited
US5709654A
Cited
US5588438A
Cited
US5117822A
Cited
US5433740A
Cited
US5913885A
Cited
US5250070A
Cited
US5264260A
Cited
US5558644A
Cited
US5211631A
Cited
US5150706A
Cited
US5267341A
Cited
US5269369A
Cited
US5246421A
Cited
US5620480A
Cited
US5423807A
Cited
US5281213A
Cited
US5281215A
Cited
US5395331A
Cited
US5269758A
Cited
US5269749A
Cited
US5248312A
Cited
US5342301A
Cited
US5569195A
Cited
US5383918A
Cited
US5342621A
Cited
US5403281A
Cited
US5676693A
Cited
US5334193A
Cited
US5365750A
Cited
US5443456A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2004-06-25 | 2004-12-25 | 2005-06-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2008-06-25 | 2008-12-25 | 2009-06-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2012-06-25 | 2012-12-25 | 2013-06-26 | $7700.00 | Window Closed / Lapsed |