Patent US3599637A successfully refreshed from Google Patents.
US5584804A
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US
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Brain resuscitation and organ preservation device and method for performing the same
Assignee: Organ Recovery Systems Inc
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Filing: 1995-02-03
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Granted: 1996-12-17
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Expires: 2015-02-03
Abstract
Abstract The invention discloses methods for preserving organs in brain-dead humans or cadavers which allows additional time for the organs to remain viable such that they may be harvested for subsequent transplantation. This invention also discloses methods for preserving and/or resuscitating organs in live (nonbrain-dead) patients, allowing for additional time to stabilize the patient's condition. The methods include the steps of instrumentizing (e.g., catheterizing, cannulating, injecting, etc.) the vessels or tissues around the organ, or the organ itself sought to be preserved and/or resuscitated, the body cavity, or cavities of the body, and introducing a temperature-controlled solution to preserve and/or resuscitate the organ(s). The temperature-controlled organ preservation solution includes components such as oxygen carrying agents, antioxidants, tissue damage reversing and protecting agents, carrier vehicles, diluents, nutrients, and anti-coagulating agents. A device which performs this method is also disclosed. This device includes a fluid reservoir, an oxygen tank, a heat exchanger and removable catheter lines.
Inventors
- 👤 Ronald M. Klatz
- 👤 Robert M. Goldman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:56
CPC Classifications
A; A01; A01N; A01N1/00; A01N1/10; A01N1/12; A01N1/122; A01N1/126; A01N1/14; A01N1/142; A01N1/143; A61; A61B; A61B16/00; A61H; A61H31/00; A61M; A61M16/00; A61M16/0054; A61M16/021; A61M16/022; A61M5/00; A61M5/14; A61M60/00; A61M60/10; A61M60/104; A61M60/109; A61M60/113; A61M60/20; A61M60/247; A61M60/253; A61M60/268; A61M60/30; A61M60/31; A61M60/36; A61M60/38; A61M60/40; A61M60/424; A61M60/427; A61M60/50; A61M60/508; A61M60/538; A61M60/546; A61B17/00; A61B2017/00969; A61M2202/00; A61M2202/04; A61M2202/0468; A61M2202/0476; A61M2210/00; A61M2210/06; A61M2210/0693; Y; Y10; Y10S; Y10S128/00; Y10S128/13
Claims Analysis
Total Claims: 41
Claim 1
Independent Claim
121 words
A method of treating tissues and/or organs in a live patient or cadaver comprising: a) accessing a body cavity of the patient or cadaver; and b) perfusing the body cavity of the patient or cadaver by: 1) lowering the temperature of the organs in the body cavity, by introducing cooled fluid into the accessed body cavity, said cooled fluid being at a temperature below body temperature; 2) inhibiting free radical damage in the organs by introducing a free radical scavenger into the accessed body cavity; and 3) oxygenating said organs by introducing an oxygen carrying agent into the accessed body cavity, whereby the metabolic rates of said tissues and/or said organs are slowed and said tissues and/or said organs remain viable.
Claim 2
Independent Claim
121 words
A method of treating tissues and/or organs in a live patient or cadaver comprising: a) accessing a body cavity of the patient or cadaver; and b) perfusing the body cavity of the patient or cadaver by: 1) lowering the temperature of the organs in the body cavity, by introducing cooled fluid into the accessed body cavity, said cooled fluid being at a temperature below body temperature; 2) inhibiting free radical damage in the organs by introducing a free radical scavenger into the accessed body cavity; and 3) oxygenating said organs by introducing an oxygen carrying agent into the accessed body cavity, whereby the metabolic rates of said tissues and/or said organs are slowed and said tissues and/or said organs remain viable.
Claim 3
Dependent Claim
26 words
The method of claim 1, wherein said method further includes the step of introducing a tissue-protecting agent and a damage-reversing agent into the accessed body cavity.
Claim 4
Dependent Claim
27 words
The method of claim 1, wherein said oxygen carrying agent is selected from the group consisting of perfluorocarbons, hemoglobin based blood substitutes and non-hemoglobin based blood substitutes.
Claim 5
Dependent Claim
13 words
The method of claim 1, wherein said fluid is approximately 40 degrees F.
Claim 6
Dependent Claim
24 words
The method of claim 1, additionally comprising the step of externally compressing the body of said live patient or cadaver proximate the body cavity.
Claim 7
Dependent Claim
18 words
The method of claim 1, wherein said free radical scavenger is selected from the group consisting of antioxidants.
Claim 8
Dependent Claim
30 words
The method of claim 6, wherein said antioxidant is selected from the group consisting of Vitamin A, Vitamin B, Vitamin C, Vitamin E, Selenium, Cystine, Cysteine, BHT, BHA and Hydergine.
Claim 9
Dependent Claim
24 words
The method of claim 1, wherein accessing the body cavity of the patient or cadaver includes instrumentizing the body cavity by piercing the skin.
Claim 10
Dependent Claim
16 words
The method of claim 8, wherein said instrumentizing the body cavity includes cannulating the body cavity.
Claim 11
Independent Claim
130 words
A method of treating tissues and/or organs in a live patient or cadaver comprising: a) accessing a cavity of the body of the patient or cadaver; and infusing the cavity of the body of the patient or cadaver by: 1) lowering the temperature of the organs in the body cavity, by introducing cooled fluid into the accessed cavity of the body, said cooled fluid being at a temperature below body temperature; 2) inhibiting free radical damage in the organs by introducing a free radical scavenger into the accessed cavity of the body; and 3) oxygenating said organs by introducing an oxygen carrying agent into the accessed cavity of the body, whereby the metabolic rates of said tissues and/or said organs are slowed and said tissues and/or said organs remain viable.
Claim 12
Independent Claim
130 words
A method of treating tissues and/or organs in a live patient or cadaver comprising: a) accessing a cavity of the body of the patient or cadaver; and infusing the cavity of the body of the patient or cadaver by: 1) lowering the temperature of the organs in the body cavity, by introducing cooled fluid into the accessed cavity of the body, said cooled fluid being at a temperature below body temperature; 2) inhibiting free radical damage in the organs by introducing a free radical scavenger into the accessed cavity of the body; and 3) oxygenating said organs by introducing an oxygen carrying agent into the accessed cavity of the body, whereby the metabolic rates of said tissues and/or said organs are slowed and said tissues and/or said organs remain viable.
Claim 13
Dependent Claim
28 words
The method of claim 10, wherein said cavity of the body is selected from the group consisting of the gastro-intestinal tract, the respiratory tract and the urinary tract.
Claim 14
Dependent Claim
28 words
The method of claim 10, wherein said method further includes the step of introducing a tissue-protecting agent and a damage-reversing agent into the accessed cavity of the body.
Claim 15
Dependent Claim
27 words
The method of claim 10, wherein said oxygen carrying agent is selected from the group consisting of perfluorocarbons, hemoglobin based blood substitutes and non-hemoglobin based blood substitutes.
Claim 16
Dependent Claim
13 words
The method of claim 10, wherein said fluid is approximately 40 degrees F.
Claim 17
Dependent Claim
26 words
The method of claim 10, additionally comprising the step of externally compressing the body of said live patient or cadaver proximate the cavity of the body.
Claim 18
Dependent Claim
18 words
The method of claim 10, wherein said free radical scavenger is selected from the group consisting of antioxidants.
Claim 19
Dependent Claim
30 words
The method of claim 16, wherein said antioxidant is selected from the group consisting of Vitamin A, Vitamin B, Vitamin C, Vitamin E, Selenium, Cystine, Cysteine, BHT, BHA and Hydergine.
Claim 20
Dependent Claim
28 words
The method of claim 11, wherein accessing the cavity of the body of the patient or cadaver includes instrumentizing the cavity of the body at a body orifice.
Claim 21
Dependent Claim
18 words
The method of claim 18, wherein said instrumentizing the cavity of the body includes cannulating the body orifice.
Claim 22
Independent Claim
70 words
A method of treating living tissue in mammals comprising: a) providing a biocompatible solution, said solution comprising an effective amount of a free radical scavenger for inhibiting free radical damage and an effective amount of an oxygen carrying agent for transporting oxygen to said tissue; b) bringing said biocompatible solution to a temperature substantially below body temperature; and c) perfusing said biocompatible solution into a body cavity of said mammal.
Claim 23
Independent Claim
70 words
A method of treating living tissue in mammals comprising: a) providing a biocompatible solution, said solution comprising an effective amount of a free radical scavenger for inhibiting free radical damage and an effective amount of an oxygen carrying agent for transporting oxygen to said tissue; b) bringing said biocompatible solution to a temperature substantially below body temperature; and c) perfusing said biocompatible solution into a body cavity of said mammal.
Claim 24
Dependent Claim
27 words
The method of claim 20, wherein said oxygen carrying agent is selected from the group consisting of perfluorocarbons, hemoglobin based blood substitutes and non-hemoglobin based blood substitutes.
Claim 25
Dependent Claim
13 words
The method of claim 20, wherein said solution is approximately 40 degrees F.
Claim 26
Dependent Claim
18 words
The method of claim 20, additionally comprising the step of retrieving said biocompatible solution from said body cavity.
Claim 27
Dependent Claim
18 words
The method of claim 20, wherein said free radical scavenger is selected from the group consisting of antioxidants.
Claim 28
Dependent Claim
30 words
The method of claim 24, wherein said antioxidant is selected from the group consisting of Vitamin A, Vitamin B, Vitamin C, Vitamin E, Selenium, Cystine, Cysteine, BHT, BHA and Hydergine.
Claim 29
Dependent Claim
29 words
The method of claim 20, wherein said perfusing said biocompatible solution into said body cavity of said mammal includes the step of instrumentizing said body cavity of said mammal.
Claim 30
Dependent Claim
16 words
The method of claim 26, wherein said instrumentizing step includes piercing the skin of said mammal.
Claim 31
Dependent Claim
14 words
The method of claim 26, wherein said instrumentizing step includes cannulation of said mammal.
Claim 32
Independent Claim
74 words
A method of treating living tissue in mammals comprising: a) providing a biocompatible solution, said solution comprising an effective amount of a free radical scavenger for inhibiting free radical damage and an effective amount of an oxygen carrying agent for transporting oxygen to said tissue; b) bringing said biocompatible solution to a temperature substantially below body temperature; and c) infusing said biocompatible solution into at least one cavity of the body of said mammal.
Claim 33
Independent Claim
74 words
A method of treating living tissue in mammals comprising: a) providing a biocompatible solution, said solution comprising an effective amount of a free radical scavenger for inhibiting free radical damage and an effective amount of an oxygen carrying agent for transporting oxygen to said tissue; b) bringing said biocompatible solution to a temperature substantially below body temperature; and c) infusing said biocompatible solution into at least one cavity of the body of said mammal.
Claim 34
Dependent Claim
31 words
The method of claim 29, wherein said cavity of the body of said mammal is selected from the group consisting of the gastro-intestinal tract, the respiratory tract and the urinary tract.
Claim 35
Dependent Claim
27 words
The method of claim 29, wherein said oxygen carrying agent is selected from the group consisting of perfluorocarbons, hemoglobin based blood substitutes and non-hemoglobin based blood substitutes.
Claim 36
Dependent Claim
20 words
The method of claim 29, additionally comprising the step of retrieving said biocompatible solution from said cavity of the body.
Claim 37
Dependent Claim
18 words
The method of claim 29, wherein said free radical scavenger is selected from the group consisting of antioxidants.
Claim 38
Dependent Claim
30 words
The method of claim 33, wherein said antioxidant is selected from the group consisting of Vitamin A, Vitamin B, Vitamin C, Vitamin E, Selenium, Cystine, Cysteine, BHT, BHA and Hydergine.
Claim 39
Dependent Claim
13 words
The method of claim 29, wherein said solution is approximately 40 degrees F.
Claim 40
Dependent Claim
37 words
The method of claim 29, wherein said infusing said biocompatible solution into said cavity of the body of said mammal includes the step of instrumentizing said cavity of the body of said mammal at a body orifice.
Claim 41
Dependent Claim
14 words
The method of claim 36, wherein said instrumentizing step includes cannulation of said mammal.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-12-17 | 2000-06-17 | 2000-12-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-12-17 | 2004-06-17 | 2004-12-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-12-17 | 2008-06-17 | 2008-12-17 | $7700.00 | Window Closed / Lapsed |