US5342621A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antithrombogenic surface
Assignee: Abbott Cardiovascular Systems Inc
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Filing: 1992-09-15
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Granted: 1994-08-30
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Expires: 2012-09-15
Abstract
Abstract An anticoagulant releasably associated with a cell membrane mimicking substance is incorporated in a biomedical polymer or polymer coating and serves to both prevent the blood from recognizing the polymer as a foreign substance as well as actively interfere in any coagulation process that may occur.
Inventors
- 👤 Robert P. Eury
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:45
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0029
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
28 words
An antithrombogenic material comprising: heparin, an anticoagulation agent, complexed with phosphatidylcholine, a cell membrane mimicking substance, so as to be releasably associated therewith, incorporated within a biomedical polymer.
Claim 2
Dependent Claim
28 words
An antithrombogenic material comprising: heparin, an anticoagulation agent, complexed with phosphatidylcholine, a cell membrane mimicking substance, so as to be releasably associated therewith, incorporated within a biomedical polymer.
Claim 3
Dependent Claim
11 words
A biomedical device formed of the antithrombogenic material of claim 1.
Claim 4
Dependent Claim
11 words
A biomedical device coated with the antithrombogenic material of claim 1.
Claim 5
Dependent Claim
9 words
A stent coated with antithrombogenic material of claim 1.
Claim 6
Dependent Claim
22 words
The antithrombogenic material of claim 1 wherein said biomedical polymer is selected from the group consisting of polyurethanes, polyamides, polycarbonates, and polyesters.
Claim 7
Dependent Claim
31 words
The antithrombogenic material of claim 1 wherein said biomedical polymer comprises a biodegradable polymer and wherein said material is applied as a film to blood contacting surfaces of a medical device.
Claim 8
Dependent Claim
14 words
The antithrombogenic material of claim 6 wherein said biodegradable polymer comprises poly-L-lactic acid (PLLA)
Claim 9
Independent Claim
61 words
A method for imparting antithrombogenic characteristics to a medical device, comprising the steps of: forming a solution which supports heparin, an anticoagulation agent, complexed with phosphatidylcholine, a cell membrane mimicking substance, so as to be releasably associated therewith; coating preselected surfaces of said medical device with said solution; and drying said coating to provide a dry film adhering to said surfaces.
Claim 10
Independent Claim
61 words
A method for imparting antithrombogenic characteristics to a medical device, comprising the steps of: forming a solution which supports heparin, an anticoagulation agent, complexed with phosphatidylcholine, a cell membrane mimicking substance, so as to be releasably associated therewith; coating preselected surfaces of said medical device with said solution; and drying said coating to provide a dry film adhering to said surfaces.
Claim 11
Dependent Claim
16 words
The method of claim 8 wherein said solution includes a heparin-phosphatidylcholine complex and poly-L-lactic acid polymer.
Claim 12
Dependent Claim
12 words
The method of claim 8 wherein said medical device comprises a stent.
Claim 13
Independent Claim
61 words
A method for imparting antithrombogenic characteristics to a medical device, comprising the steps of: forming a dry film containing heparin, an anticoagulation agent, complexed with phosphatidylcholine, a cell mimicking substance, so as to be releasably associated therewith; placing said dry film on selected surfaces of said medical device; heating said dry film to soften and adhere said film to said surfaces.
Claim 14
Independent Claim
61 words
A method for imparting antithrombogenic characteristics to a medical device, comprising the steps of: forming a dry film containing heparin, an anticoagulation agent, complexed with phosphatidylcholine, a cell mimicking substance, so as to be releasably associated therewith; placing said dry film on selected surfaces of said medical device; heating said dry film to soften and adhere said film to said surfaces.
Claim 15
Dependent Claim
13 words
The method of claim 16 wherein said film further contains a biodegradable polymer.
Claim 16
Dependent Claim
11 words
The method of claim 12 wherein said polymer comprises poly-L-lactic acid.
Claim 17
Independent Claim
52 words
A method for producing a medical device having antithrombogenic characteristics, comprising the steps of: forming a substance having heparin, an anticoagulation agent complexed with phosphatidylcholine, a cell mimicking compound so as to be releasably associated therewith; intimately admixing said substance with a structural polymer; and forming said medical device with said admixture.
Claim 18
Independent Claim
52 words
A method for producing a medical device having antithrombogenic characteristics, comprising the steps of: forming a substance having heparin, an anticoagulation agent complexed with phosphatidylcholine, a cell mimicking compound so as to be releasably associated therewith; intimately admixing said substance with a structural polymer; and forming said medical device with said admixture.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-08-29 | 1998-02-28 | 1998-08-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-08-29 | 2002-02-28 | 2002-08-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-08-29 | 2006-02-28 | 2006-08-30 | $7700.00 | Window Closed / Lapsed |