US5015238A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Expandable obturator and catheter assembly including same
Assignee: Becton Dickinson and Co
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Filing: 1989-09-20
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Granted: 1991-05-14
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Expires: 2009-09-20
Abstract
Abstract An oburator includes a solid substantially stiff rod of a nonhydrophilic polymer coated with a layer of a hydrophilic polyurethane which may have an antithrombogenic agent bulk distributing therein. When the hydrophilic polyurethane comes into contact with an aqueous liquid such as water, saline or a body fluid, it absorbs the liquid and expands thereby enlarging the diameter of the obturator. Another aspect of the invention is an assembly of a catheter and the obturator of the invention. When the obturator is emplaced in the catheter and brought into contact with a liquid, it expands, releases the antithrombogenic agent and contacts the lumen wall of the catheter thereby forming a seal which prevents backflow of a body fluid.
Inventors
- 👤 Donald D. Solomon
- 👤 Mutlu Karakelle
- 👤 Richard W. Beck
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:15
CPC Classifications
A; A61; A61M; A61M25/00; A61L; A61L29/00; A61L29/08; A61L29/085; A61L29/14; A61L29/16; A61L2300/00; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/42; A61L2300/45
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
49 words
An obturator comprising a substantially nonhydrophilic polymeric rod coated with an adhering substantially hydrophilic polyurethane having a medicinal agent bulk distributed therein said polyurethane being capable of absorbing a liquid, releasing said medicinal agent and expanding to form a seal when the coated rod is inserted into a catheter.
Claim 2
Dependent Claim
49 words
An obturator comprising a substantially nonhydrophilic polymeric rod coated with an adhering substantially hydrophilic polyurethane having a medicinal agent bulk distributed therein said polyurethane being capable of absorbing a liquid, releasing said medicinal agent and expanding to form a seal when the coated rod is inserted into a catheter.
Claim 3
Dependent Claim
22 words
The obturator of claim 1 wherein said hydrophilic polyurethane comprises the reaction product of a diisocyanate, polyethyleneoxide glycol and a chain extender.
Claim 4
Dependent Claim
24 words
The obturator of claim 2 wherein said diisocyanate is selected from the group consisting of 4,4'-diphenylmethane diisocyanate, 3-3'-diphenylmethane diisocyanate, isophorone diisocyanate and hexamethylene diisocyanate.
Claim 5
Dependent Claim
35 words
The obturator of claim 2 wherein said chain extender is selected from the group consisting of 1,4-butanediol, ethylene glycol, diethylene glycol, triethylene glycol, 1,2-propanediol, 1,3-propanediol, 1,6-hexanediol, 1,4-bis-hydroxymethyl cyclohexane, hydroquinone dihydroxyethyl ether, ethanolamine, ethylenediamine and hexamethylenediamine.
Claim 6
Dependent Claim
17 words
The obturator of claim 2 wherein said polyethyleneoxide has a molecular weight of about 600 to 16,000.
Claim 7
Dependent Claim
31 words
The obturator of claim 2 wherein said hydrophilic polyurethane further comprises the reaction product of a polyglycol selected from the group consisting of polypropyleneoxide glycol, polytetramethyleneoxide glycol and a silicone glycol.
Claim 8
Dependent Claim
25 words
The obturator of claim 1 wherein said medicinal agent is selected from the group consisting of an antiinfective agent, an antibiotic and an antithrombogenic agent.
Claim 9
Dependent Claim
36 words
The obturator of claim 7 wherein said antithrombogenic agent is selected from the group consisting of a prostaglandin, urokinase, streptokinase, tissue plasminogen activator, heparin, a heparin salt and a complex of heparin with a quaternary salt.
Claim 10
Dependent Claim
35 words
An obturator comprising a substantially nonhydrophilic rod coated with an adhering substantially hydrophilic polyurethane, said hydrophilic polyurethane being capable of absorbing an aqueous liquid and expanding to form a seal when inserted into a catheter.
Claim 11
Dependent Claim
35 words
An obturator comprising a substantially nonhydrophilic rod coated with an adhering substantially hydrophilic polyurethane, said hydrophilic polyurethane being capable of absorbing an aqueous liquid and expanding to form a seal when inserted into a catheter.
Claim 12
Dependent Claim
22 words
The obturator of claim 9 wherein said rod is selected from the group consisting of a metal rod and a polymeric rod.
Claim 13
Dependent Claim
26 words
The obturator of claim 10 wherein said polymeric rod is selected from the group consisting of a polyolefin, polytetrafluoroethylene, polyester, polyamide, polyvinyl chloride and liquid crystal.
Claim 14
Dependent Claim
60 words
An obturator comprising a substantially nonhydrophilic polyurethane rod and a coating thereon, said coating comprising a substantially hydrophilic polyurethane comprising the reaction product of 4,4'-diphenylmethane diisocyanate, polyethyleneoxide glycol and butanediol, said hydrophilic polyurethane having a heparinoid bulk distributed therein and being capable of absorbing a liquid, releasing said heparinoid and expanding to form a seal when inserted into a catheter.
Claim 15
Dependent Claim
60 words
An obturator comprising a substantially nonhydrophilic polyurethane rod and a coating thereon, said coating comprising a substantially hydrophilic polyurethane comprising the reaction product of 4,4'-diphenylmethane diisocyanate, polyethyleneoxide glycol and butanediol, said hydrophilic polyurethane having a heparinoid bulk distributed therein and being capable of absorbing a liquid, releasing said heparinoid and expanding to form a seal when inserted into a catheter.
Claim 16
Dependent Claim
63 words
An assembly comprising a polymeric catheter and an obturator dimensioned to fit therein, said obturator including a substantially nonhydrophilic polymeric rod having a coating thereon, said coating comprising a substantially hydrophilic polyurethane having a medicinal agent bulk distributed therein, said hydrophilic polyurethane being capable of absorbing a liquid, releasing said medicinal agent and expanding to form a seal when inserted into said catheter.
Claim 17
Dependent Claim
63 words
An assembly comprising a polymeric catheter and an obturator dimensioned to fit therein, said obturator including a substantially nonhydrophilic polymeric rod having a coating thereon, said coating comprising a substantially hydrophilic polyurethane having a medicinal agent bulk distributed therein, said hydrophilic polyurethane being capable of absorbing a liquid, releasing said medicinal agent and expanding to form a seal when inserted into said catheter.
Claim 18
Dependent Claim
27 words
The assembly of claim 13 wherein said polymer is rod is selected from the group consisting of a polyolefin, polytetrafluoroethylene, polyester, polyamide, polyvinyl chloride and liquid crystal.
Claim 19
Dependent Claim
22 words
The assembly of claim 13 wherein said hydrophilic polyurethane comprises the reaction product of a diisocyanate, polyethyleneoxide glycol and a chain extender.
Claim 20
Dependent Claim
24 words
The assembly of claim 15 wherein said diisocyanate is selected from the group consisting of 4,4'-diphenylmethane diisocyanate, 3,3'-diphenylmethane diisocyanate, isophorone diisocyanate and hexamethylene diisocyanate.
Claim 21
Dependent Claim
35 words
The assembly of claim 15 wherein said chain extender is selected from the group consisting of 1,4-butanediol, ethylene glycol, diethylene glycol, triethylene glycol, 1,2-propanediol, 1,3-propanediol, 1,6-hexanediol, 1,4-bis-hydroxymethyl cyclohexane, hydroquinone dihydroxyethyl ether, ethanolamine, ethylenediamine and hexamethylenediamine.
Claim 22
Dependent Claim
17 words
The assembly of claim 15 wherein said polyethyleneoxide has a molecular weight of about 600 to 16,000.
Claim 23
Dependent Claim
31 words
The assembly of claim 15 wherein said hydrophilic polyurethane further comprises the reaction product of a polyglycol selected from the group consisting of polypropyleneoxide glycol, polytetramethyleneoxide glycol and a silicone glycol.
Claim 24
Dependent Claim
25 words
The assembly of claim 13 wherein said medicinal agent is selected from the group consisting of an antiinfective agent, an antibiotic and an antithrombogenic agent.
Claim 25
Dependent Claim
35 words
The assembly of claim 20 wherein said antithrombogenic agent is selected from the group consisting of a prostaglandin, urokinase, streptokinase, tissue plasminogen activator, heparin, a heparin salt and a complex of heparin with quaternary salt.
Claim 26
Dependent Claim
12 words
The assembly of claim 13 wherein said catheter includes a radiopaque agent.
Claim 27
Dependent Claim
47 words
An assembly comprising a polymeric catheter and an obturator dimensioned to fit therein, said obturator including a substantially nonhydrophilic rod coated with a substantially hydrophilic polyurethane, said hydrophilic polyurethane being capable of absorbing an aqueous liquid and expanding to form a seal when inserted into said catheter.
Claim 28
Dependent Claim
47 words
An assembly comprising a polymeric catheter and an obturator dimensioned to fit therein, said obturator including a substantially nonhydrophilic rod coated with a substantially hydrophilic polyurethane, said hydrophilic polyurethane being capable of absorbing an aqueous liquid and expanding to form a seal when inserted into said catheter.
Claim 29
Dependent Claim
79 words
An assembly comprising a polymeric catheter and an obturator dimensioned to fit therein, said obturator including a substantially nonhydrophilic polymeric rod and a coating thereon, said coating comprising a substantially hydrophilic polyurethane comprising the reaction product of 4,4'-diphenylmethane diisocyanate, polyethyleneoxide glycol and butanediol, said hydrophilic polyurethane having a heparinoid bulk distributed therein and being capable of absorbing a liquid, releasing said heparinoid and expanding to form a seal when inserted into said catheter, said catheter including a radiopaque agent.
Claim 30
Dependent Claim
79 words
An assembly comprising a polymeric catheter and an obturator dimensioned to fit therein, said obturator including a substantially nonhydrophilic polymeric rod and a coating thereon, said coating comprising a substantially hydrophilic polyurethane comprising the reaction product of 4,4'-diphenylmethane diisocyanate, polyethyleneoxide glycol and butanediol, said hydrophilic polyurethane having a heparinoid bulk distributed therein and being capable of absorbing a liquid, releasing said heparinoid and expanding to form a seal when inserted into said catheter, said catheter including a radiopaque agent.
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